Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2

Csiszár, Anna; Bagi, Zsolt; Fehér, Attila; Recchia, Fabio A.; Sonntag, William E.; Ungvári, Zoltán; Cabo, Rafael de

doi:10.1096/fasebj.25.1_supplement.1093.13

Cited by 5 publications

(6 citation statements)

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“…In those with Nrf2 expression, resveratrol improved vasodilation by enhancing acetylcholine levels in femoral artery. Therefore, resveratrol protects the endothelium through Nrf2 activation in vitro and in vivo (Csiszar et al, 2011;Ungvari et al, 2010). These findings support using dietary antioxidants in management of various disorders related to increased oxidative stress including chronic obstructive pulmonary disease (Bryan, Olayanju, Goldring, & Park, 2013;Kode et al, 2008;Rahman, 2007).…”

Section: Effect On Oxidative Stressmentioning

confidence: 63%

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Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Shahcheraghi

Salemi

Small

et al. 2023

Phytotherapy Research

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Usually, in aerobic metabolism, natural materials including nucleic acids, proteins, and lipids can experience auxiliary injury by oxidative responses. This damage produced by reactive oxygen/nitrogen species has been identified as “oxidative stress.” As a natural polyphenol got from red wine and peanuts, resveratrol is one of the most eminent anti‐aging mixtures. Based on many studies', resveratrol hinders destructive effects of inflammatory causes and reactive oxygen radicals in several tissues. The nuclear erythroid 2‐related factor 2 is a factor related to transcription with anti‐inflammatory, antioxidant possessions which is complicated by enzyme biotransformation and biosynthesis of lipids and carbohydrates. This review provides current understanding and information about the character of resveratrol against oxidative stress and regulation of inflammation via Nrf2 signaling pathway.

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Section: Effect On Oxidative Stressmentioning

confidence: 63%

Section: Effect On Oxidative Stressmentioning

confidence: 99%

Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Shahcheraghi

Salemi

Small

et al. 2023

Phytotherapy Research

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“…The degree of these ISG inductions was then compared with spheroids that were pretreated with RES 24 h prior to poly I:C transfection ( Figure 1 B, right columns). Here, we pretreated cells with 20 μM of RES because previous studies reported that low doses of RES ranging from 3–30 μM protected cells from oxidative stress by decreasing mitochondrial ROS production while increasing the expression of SIRT1 and its downstream antioxidant proteins, such as peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) and nuclear respiratory factor 1 (NRF-1) [ 26 , 27 , 28 , 29 , 30 , 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…To the best of our knowledge, there have not been many attempts to understand the role of RES on mtRNA expression. Previous studies reported that a low dosage of RES in the range of 3–30 μM resulted in an increased number of mitochondria, mtDNA copies, mitochondrial transcription factor (TFAM), and proteins encoded by the mitochondrial genome to support mitochondrial function [ 28 , 52 , 53 ]. Based on this evidence, we presume that in healthy conditions, the antioxidant RES may play a supporting role to ensure active mitochondrial biogenesis.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Attenuates the Mitochondrial RNA-Mediated Cellular Response to Immunogenic Stress

Yoon

Lee

et al. 2023

IJMS

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Human mitochondria contain a circular genome that encodes 13 subunits of the oxidative phosphorylation system. In addition to their role as powerhouses of the cells, mitochondria are also involved in innate immunity as the mitochondrial genome generates long double-stranded RNAs (dsRNAs) that can activate the dsRNA-sensing pattern recognition receptors. Recent evidence shows that these mitochondrial dsRNAs (mt-dsRNAs) are closely associated with the pathogenesis of human diseases that accompany inflammation and aberrant immune activation, such as Huntington’s disease, osteoarthritis, and autoimmune Sjögren’s syndrome. Yet, small chemicals that can protect cells from a mt-dsRNA-mediated immune response remain largely unexplored. Here, we investigate the potential of resveratrol (RES), a plant-derived polyphenol with antioxidant properties, on suppressing mt-dsRNA-mediated immune activation. We show that RES can revert the downstream response to immunogenic stressors that elevate mitochondrial RNA expressions, such as stimulation by exogenous dsRNAs or inhibition of ATP synthase. Through high-throughput sequencing, we find that RES can regulate mt-dsRNA expression, interferon response, and other cellular responses induced by these stressors. Notably, RES treatment fails to counter the effect of an endoplasmic reticulum stressor that does not affect the expression of mitochondrial RNAs. Overall, our study demonstrates the potential usage of RES to alleviate the mt-dsRNA-mediated immunogenic stress response.

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“…The possible action mechanisms through which the carcinogenic processes are inhibited by polyphenols are illustrated in Figure 4. and increases the Nrf2 transcriptional activity (Csiszar et al, 2011;Shen et al, 2017). EGCG reduces the cyclin D1 expression, induces the expression of p27Kip1 and p21waf1/Cip1 genes, and inhibits CDKs 2 and 4 thereby blocking the progression of cell cycle MCF-7 at G1 phase.…”

Section: Polyphenolsmentioning

confidence: 99%

Phytobioactive compounds as therapeutic agents for human diseases: A review

Riaz

Khalid

Afzal³

et al. 2023

Food Science & Nutrition

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Phytobioactive compounds are plant secondary metabolites and bioactive compounds abundantly present in medicinal plants and have remarkable therapeutic potential. Oxidative stress and antibiotic resistance are major causes of present‐day ailments such as diabetes, atherosclerosis, cardiovascular disorders, cancer, and inflammation. The data for this review were collected from Google Scholar, PubMed, Directory of Open Access Journals (DOAJ), and Science Direct by using keywords: “Medicinal plants, Phytobioactive compounds, Polyphenols, Alkaloids, Carotenoids etc.” Several studies have reported the pharmacological and therapeutic potential of the phytobioactives. Polyphenols, alkaloids, terpenes, and polysaccharides isolated from medicinal plants showed remarkable antioxidant, anticancer, cytotoxic, anti‐inflammatory, cardioprotective, hepatoprotective, immunomodulatory, neuroprotective, and antidiabetic activities. This literature review was planned to provide comprehensive insight into the biopharmacological and therapeutic potential of phytobioactive compounds. The techniques used for the extraction and isolation of phytobioactive compounds, and bioassays required for their biological activities such as antioxidant, antimicrobial, anti‐inflammatory, and cytotoxic activities, have been discussed. Characterization techniques for the structural elucidation of phytobioactive compounds such as HPLC, TLC, FTIR, GC–MS/MS, and NMR have also been discussed. This review concludes that phytobioactive compounds may be used as potential alternative to synthetic compounds as therapeutic agents for the treatment of various diseases.

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Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2

Cited by 5 publications

References 0 publications

Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Resveratrol Attenuates the Mitochondrial RNA-Mediated Cellular Response to Immunogenic Stress

Phytobioactive compounds as therapeutic agents for human diseases: A review

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