Resveratrol confers neuroprotection against high-fat diet in a mouse model of Alzheimer's disease via modulation of proteolytic mechanisms

Sarroca, Sara; Gatius, Alaó; Rodrı́guez-Farré, Eduard; Vı́lchez, David; Pallàs, Mercè; Griñán-Ferré, Christian; Sanfeliu, Coral; Corpas, Rubén

doi:10.1016/j.jnutbio.2020.108569

Cited by 36 publications

(18 citation statements)

References 122 publications

(166 reference statements)

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“…Qi et al demonstrated improved dynamic spatial working memory (Y-maze test) and improved escape latency (Morris Water Maze), showing that the direct administration of RSV will prevent AD-driven pathological impairments. Similarly, Sarroca et al [ 116 ] also recently demonstrated some neuroprotective benefits of RSV by showing that an orally fed dose of RSV (120 mg/kg/day; 16 weeks) was protective against a number of AD pathologies (increased APP content, BACE1 activity) as well as prevented impairments in cognitive behavior (open field test, novel object recognition test) in a high-fat mouse model of AD (C57BL/6, 60% kcal from fat).…”

Section: Alzheimer’s Diseasementioning

confidence: 91%

Resveratrol, Metabolic Dysregulation, and Alzheimer’s Disease: Considerations for Neurogenerative Disease

Yang

Bagit

MacPherson

2021

IJMS

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Alzheimer’s disease (AD) has traditionally been discussed as a disease where serious cognitive decline is a result of Aβ-plaque accumulation, tau tangle formation, and neurodegeneration. Recently, it has been shown that metabolic dysregulation observed with insulin resistance and type-2 diabetes actively contributes to the progression of AD. One of the pathologies linking metabolic disease to AD is the release of inflammatory cytokines that contribute to the development of brain neuroinflammation and mitochondrial dysfunction, ultimately resulting in amyloid-beta peptide production and accumulation. Improving these metabolic impairments has been shown to be effective at reducing AD progression and improving cognitive function. The polyphenol resveratrol (RSV) improves peripheral metabolic disorders and may provide similar benefits centrally in the brain. RSV reduces inflammatory cytokine release, improves mitochondrial energetic function, and improves Aβ-peptide clearance by activating SIRT1 and AMPK. RSV has also been linked to improved cognitive function; however, the mechanisms of action are less defined. However, there is evidence to suggest that chronic RSV-driven AMPK activation may be detrimental to synaptic function and growth, which would directly impact cognition. This review will discuss the benefits and adverse effects of RSV on the brain, highlighting the major signaling pathways and some of the gaps surrounding the use of RSV as a treatment for AD.

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Section: Alzheimer’s Diseasementioning

confidence: 91%

Resveratrol, Metabolic Dysregulation, and Alzheimer’s Disease: Considerations for Neurogenerative Disease

Yang

Bagit

MacPherson

2021

IJMS

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“…On the basis of the available data, it can be concluded that the beneficial effects of these natural compounds are related to a number of different mechanisms. RV acts as an antioxidant [ 127 , 128 , 129 , 130 , 137 , 139 ], but can also directly affect Aβ formation and accumulation by acting on the ubiquitin-proteasome system [ 133 , 134 , 135 , 136 ] as well as by activating SIRT1 [ 138 , 145 , 149 , 150 ]. The situation is similar for curcumin.…”

Section: Discussionmentioning

confidence: 99%

“…These range from molecular disorders, including processes responsible for the accumulation of abnormal proteins. One of the most important pathways whose disruption affects the development of AD is the ubiquitin-proteasome system, which is the primary proteolytic mechanism to aberrant clearance proteins, including Aβ and p-Tau [ 133 ]. Studies on AD models indicate that RV improves proteosome functionality in AD models.…”

Section: Natural Products and Alzheimer’s Diseasementioning

confidence: 99%

Some Candidate Drugs for Pharmacotherapy of Alzheimer’s Disease

Miziak

Błaszczyk²,

Czuczwar

2021

Pharmaceuticals

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Alzheimer’s disease (AD; progressive neurodegenerative disorder) is associated with cognitive and functional impairment with accompanying neuropsychiatric symptoms. The available pharmacological treatment is of a symptomatic nature and, as such, it does not modify the cause of AD. The currently used drugs to enhance cognition include an N-methyl-d-aspartate receptor antagonist (memantine) and cholinesterase inhibitors. The PUBMED, Medical Subject Heading and Clinical Trials databases were used for searching relevant data. Novel treatments are focused on already approved drugs for other conditions and also searching for innovative drugs encompassing investigational compounds. Among the approved drugs, we investigated, are intranasal insulin (and other antidiabetic drugs: liraglitude, pioglitazone and metformin), bexarotene (an anti-cancer drug and a retinoid X receptor agonist) or antidepressant drugs (citalopram, escitalopram, sertraline, mirtazapine). The latter, especially when combined with antipsychotics (for instance quetiapine or risperidone), were shown to reduce neuropsychiatric symptoms in AD patients. The former enhanced cognition. Procognitive effects may be also expected with dietary antioxidative and anti-inflammatory supplements—curcumin, myricetin, and resveratrol. Considering a close relationship between brain ischemia and AD, they may also reduce post-brain ischemia neurodegeneration. An investigational compound, CN-105 (a lipoprotein E agonist), has a very good profile in AD preclinical studies, and its clinical trial for postoperative dementia is starting soon.

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“…Diets too dense in fat, and especially trans saturated fat has been reported to contribute to a number of diseases, like hypertension, obesity and diabetes (Gayed et al, 2021;Otagiri et al, 2021). However, excessive fat has also been proven to affect brain diseases, .2020.3.4(5) especially those related with ageing, such as Alzheimer's disease (Sarroca et al, 2021). Diets with a high level of protein intake is associated with kidney failure (Kim et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Food consumption knowledge and habits in a developing country: a case of Lebanon

Boustani¹,

Ferreira²,

Guiné³

2021

IRD

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This research work investigated the Lebanese consumers' knowledge about food fibre and their food habits according to age groups and gender. The study was conducted from January 2021 till end of March 2021. Due to the pandemic of Covid-19 and the lockdown, the questionnaire was administered randomly through social media. The survey consisted of a longitudinal study carried out on a non-probabilistic convenience sample of 258 Lebanese participants. The responses were used to undertake a quantitative, descriptive and analytical study. The questionnaires received and considered valid, were mostly from women (59.7%) and essentially living in an urban environment (78.3%). To analyse the data, basic descriptive statistics were considered on a first level. Additionally, statistical tests were also carried out (Student t test for comparisons between two groups). Finally, results and analysis were done to evaluate the importance of food knowledge among these people in addition to their eating habits and the possible gender differences. The results revealed that there are some gender inequalities (F=6.238, α= 0.0013) in terms of knowledge about food fibre, but no living environment differences were found (F=0.36, α=0.85). Additionally, consumption habits showed major differences between female and male food behaviour, especially when it comes to eating: the frequency of eating outside from home, eating fast food and consuming fruits. The value of this study focuses on the food knowledge and habits in Lebanon, specifically in a country defined by a multi-ethnical diversity and religiosity and where food habits were mainly related to social behaviour. Therefore, this study adds more knowledge about these people's food behaviour and valuable information about specific food attitudes.

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Resveratrol confers neuroprotection against high-fat diet in a mouse model of Alzheimer's disease via modulation of proteolytic mechanisms

Cited by 36 publications

References 122 publications

Resveratrol, Metabolic Dysregulation, and Alzheimer’s Disease: Considerations for Neurogenerative Disease

Resveratrol, Metabolic Dysregulation, and Alzheimer’s Disease: Considerations for Neurogenerative Disease

Some Candidate Drugs for Pharmacotherapy of Alzheimer’s Disease

Food consumption knowledge and habits in a developing country: a case of Lebanon

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