Resveratrol Enhances the Cytotoxic Activity of Lymphocytes from Menopausal Women

Credico, Andrea Di; Gaggi, Giulia; Izzicupo, Pascal; Bucci, Ines; Baldassarre, Angela Di

doi:10.3390/antiox10121914

Cited by 5 publications

(3 citation statements)

References 68 publications

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“…A pilot study in overweight and obese postmenopausal women with high body mass index (BMI ≥ 25 kg/m2) to determine the clinical effect of resveratrol on systemic sex steroid hormones [74]. Forty subjects initiated the resveratrol intervention (1 g daily for 12 weeks).…”

Section: Women's Healthmentioning

confidence: 99%

Resveratrol, Multiple Bioactivities for a Wide Range of Health Benefits – New Innovative Extracts for Nutraceutical, Pharmaceutical, and Cosmetics Applications

Traynard¹

2024

Resveratrol - Recent Advances, Application, and Therapeutic Potential

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Resveratrol (trans-resveratrol or 3,4′,5-trihydroxystilbene) is a polyphenol naturally present in grape skin and seeds. New innovative concentrated extracts produced by microorganisms or with innovative, ecological extraction techniques allow a new generation of high-quality ingredients for a diversity of product applications in nutraceuticals, cosmetics, and pharmaceuticals. Resveratrol exerts antioxidant and anti-inflammatory properties while promoting sirtuins 1 activities and mitochondrial functions. It also modulates multiple cellular signaling molecules, such as VEGF, caspases, cytokines NF-kB, vascular cell adhesion molecule, IGF-1, PPARs, and COX-2. Its clinical benefits have been demonstrated mainly in cognitive health, menopause, bone health, cardiovascular health, glucose metabolism, sport nutrition, and skin health. This chapter reviews the bioactivities of resveratrol, its clinical benefits, and detail its potential applications in several product categories in the growing field of health and nutrition product innovation. Resveratrol-based products may participate to provide new natural and complementary solutions for a global approach to health support and maintenance.

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Section: Women's Healthmentioning

confidence: 99%

Resveratrol, Multiple Bioactivities for a Wide Range of Health Benefits – New Innovative Extracts for Nutraceutical, Pharmaceutical, and Cosmetics Applications

Traynard¹

2024

Resveratrol - Recent Advances, Application, and Therapeutic Potential

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“…Immunofluorescent analysis was performed as previously described (D'amico et al, 2016;Di Credico et al, 2021a). Briefly, cells were fixed with 4% paraformaldehyde for 10 min, permeabilized with 0.5% Triton X-100 for 15 min and incubated in 5% bovine serum albumin (BSA) for 20 min at room temperature.…”

Section: Immunofluorescent Analysismentioning

confidence: 99%

Human mesenchymal amniotic fluid stem cells reveal an unexpected neuronal potential differentiating into functional spinal motor neurons

Gaggi

Credico

Guarnieri

et al. 2022

Front. Cell Dev. Biol.

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Human amniotic fluids stem cells (hAFSCs) can be easily isolated from the amniotic fluid during routinely scheduled amniocentesis. Unlike hiPSCs or hESC, they are neither tumorigenic nor immunogenic and their use does not rise ethical or safety issues: for these reasons they may represent a good candidate for the regenerative medicine. hAFSCs are generally considered multipotent and committed towards the mesodermal lineages; however, they express many pluripotent markers and share some epigenetic features with hiPSCs. Hence, we hypothesized that hAFSCs may overcome their mesodermal commitment differentiating into to ectodermal lineages. Here we demonstrated that by the sequential exposure to specific factors, hAFSCs can give rise to spinal motor neurons (MNs), as evidenced by the gradual gene and protein upregulation of early and late MN markers (PAX6, ISL1, HB9, NF-L, vAChT). When co-cultured with myotubes, hAFSCs-derived MNs were able to create functional neuromuscular junctions that induced robust skeletal muscle contractions. These data demonstrated the hAFSCs are not restricted to mesodermal commitment and can generate functional MNs thus outlining an ethically acceptable strategy for the study and treatment of the neurodegenerative diseases.

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“…Recent studies suggest that antioxidant administration may restore mitochondria. Resveratrol (3,5,4′-trihydroxy-trans-stilbene), a natural plant product, has been reported to have antioxidant effects and maintain mitochondrial function [ 7 , 8 ]. The protective role of resveratrol in mitochondrial dysfunction-related diseases, such as cardiac diseases [ 9 ], hypoxic ischemic injury [ 10 ], and neurodegenerative disorders [ 11 ], has been well established.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Potential of Resveratrol in Dry Eye Disease by Restoring Mitochondrial Function

Chen

Zhang

Zheng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background and Significance. Dry eye disease (DED) is a prevalent optic surface illness with a high incidence worldwide that is caused by a variety of factors, including mitochondrial dysfunction. Resveratrol has been confirmed to protect the eye surface in DED, and as an antioxidant, resveratrol can maintain mitochondrial function. Therefore, we investigated whether resveratrol can improve DED by restoring mitochondrial function. Methods. The mitochondrial dysfunction of HCE-2 human corneal epithelial cells was induced by high osmotic pressure exposure and treated with resveratrol (50 μM). Western blotting was used to detect the expression of the antioxidant proteins SOD2, GPx, and SIRT1, and flow cytometry was used to detect cell apoptosis and ROS production. The DED mouse model was induced by 0.2% benzalkonium chloride (BAC) and treated with resveratrol. The tear yield was measured by the phenol cotton thread test, the density of cup cells in the conjunctiva was measured by periodic acid-Schiff (PAS) staining, and the expression levels of SIRT1, GPx, and SOD2 in lacrimal glands were detected by Western blotting. Results. In hypertonic conditions, the apoptosis of HCE-2 cells increased, the expression of the antioxidant proteins SOD2 and GPx decreased, ROS production increased, and the expression of SIRT1 protein, an essential regulator of mitochondrial function, was downregulated. Treatment with resveratrol reversed the mitochondrial dysfunction mediated by high osmotic pressure. In the DED mouse model, resveratrol treatment promoted tear production and goblet cell number in DED mice, decreased corneal fluorescein staining, upregulated SIRT1 expression, and induced SOD2 and GPx expression in DED mice. Conclusion. Resveratrol alleviates mitochondrial dysfunction by promoting SIRT1 expression, thus reducing ocular surface injury in mice with dry eye. This study suggests a new path against DED.

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Resveratrol Enhances the Cytotoxic Activity of Lymphocytes from Menopausal Women

Cited by 5 publications

References 68 publications

Resveratrol, Multiple Bioactivities for a Wide Range of Health Benefits – New Innovative Extracts for Nutraceutical, Pharmaceutical, and Cosmetics Applications

Resveratrol, Multiple Bioactivities for a Wide Range of Health Benefits – New Innovative Extracts for Nutraceutical, Pharmaceutical, and Cosmetics Applications

Human mesenchymal amniotic fluid stem cells reveal an unexpected neuronal potential differentiating into functional spinal motor neurons

Ameliorative Potential of Resveratrol in Dry Eye Disease by Restoring Mitochondrial Function

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