Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases

Pannu, Naveet

doi:10.1016/j.biopha.2018.11.075

Cited by 188 publications

(145 citation statements)

References 161 publications

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“…In addition to its antioxidant properties, treatment with resveratrol improves mitochondrial OXPHOS and biogenesis by activating Sirt1 and Sirt3 in experimental models of insulin resistance . Although treatment with resveratrol has shown promising results in preclinical studies, no effect of resveratrol was observed on different markers of cardiovascular disease risk in ageing and obese individuals . Recent studies have demonstrated that resveratrol supplementation improves skeletal muscle mitochondrial function, however, it does not improve insulin sensitivity in people at risk of or with T2DM .…”

Section: Lifestyle and Pharmacological Interventions To Target Mitochmentioning

confidence: 99%

“…187,306 Although treatment with resveratrol has shown promising results in preclinical studies, 307-309 no effect of resveratrol was observed on different markers of cardiovascular disease risk in ageing and obese individuals. 310 Recent studies have demonstrated that resveratrol supplementation improves skeletal muscle mitochondrial function, however, it does not improve insulin sensitivity in people at risk of or with T2DM. 311,312 Further studies aiming to understand resveratrol metabolism and pharmacokinetics, may therefore be required to realize the therapeutic potential of this approach.…”

Section: Improving Mitochondrial Functionmentioning

confidence: 99%

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Altered mitochondrial metabolism in the insulin‐resistant heart

et al. 2019

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Obesity‐induced insulin resistance and type 2 diabetes mellitus can ultimately result in various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is characterized by metabolic disturbances such as impaired glucose oxidation and an increased reliance on fatty acid (FA) oxidation. Mitochondrial dysfunction has often been associated with the altered metabolic function in the diabetic heart, and may result from FA‐induced lipotoxicity and uncoupling of oxidative phosphorylation. In this review, we address the metabolic changes in the diabetic heart, focusing on the loss of metabolic flexibility and cardiac mitochondrial function. We consider the alterations observed in mitochondrial substrate utilization, bioenergetics and dynamics, and highlight new areas of research which may improve our understanding of the cause and effect of cardiac mitochondrial dysfunction in diabetes. Finally, we explore how lifestyle (nutrition and exercise) and pharmacological interventions can prevent and treat metabolic and mitochondrial dysfunction in diabetes.

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Section: Lifestyle and Pharmacological Interventions To Target Mitochmentioning

confidence: 99%

Section: Improving Mitochondrial Functionmentioning

confidence: 99%

Altered mitochondrial metabolism in the insulin‐resistant heart

et al. 2019

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“…Resveratrol is a naturally occurring polyphenol with anti‐inflammatory, antioxidative, antidiabetic, and neuroprotective effects (Pezzuto, ). The resveratrol‐activated SIRT1 pathway is associated with deacetylating activity, thereby resulting in alterations in various downstream regulators, such as PGC‐1α (Pannu & Bhatnagar, ). Increased SIRT1 activity triggered by elevated NAD levels increases the transcriptional activity of PGC‐1α (Rodgers et al, ).…”

Section: Effect Of Antiaging Drugs On Pgc‐1α Activationmentioning

confidence: 99%

PGC‐1α, a potential therapeutic target against kidney aging

et al. 2019

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Aging is defined as changes in an organism over time. The proportion of the aged population is markedly increasing worldwide. The kidney, as an essential organ with a high energy requirement, is one of the most susceptible organs to aging. It is involved in glucose metabolism via gluconeogenesis, glucose filtration and reabsorption, and glucose utilization. Proximal tubular epithelial cells (PTECs) depend on lipid metabolism to meet the high demand for ATP. Recent studies have shown that aging‐related kidney dysfunction is highly associated with metabolic changes in the kidney. Peroxisome proliferator‐activated receptor gamma coactivator‐1 alpha (PGC‐1α), a transcriptional coactivator, plays a major role in the regulation of mitochondrial biogenesis, peroxisomal biogenesis, and glucose and lipid metabolism. PGC‐1α is abundant in tissues, including kidney PTECs, which demand high energy. Many in vitro and in vivo studies have demonstrated that the activation of PGC‐1α by genetic or pharmacological intervention prevents telomere shortening and aging‐related changes in the skeletal muscle, heart, and brain. The activation of PGC‐1α can also prevent kidney dysfunction in various kidney diseases. Therefore, a better understanding of the effect of PGC‐1α activation in various organs on aging and kidney diseases may unveil a potential therapeutic strategy against kidney aging.

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“…As we know, the disadvantages of conventional experimental approaches are that they are time consuming, laborious, expensive, and difficult for systematic analysis of the complex interactions between compounds and their related target proteins. For example, the resveratrol is a bioactive compound found in red wine that has been demonstrated to have antioxidant, cardioprotective, anticancer, antidiabetic, neuroprotective, and antiaging activities (Koushki, Amiri‐Dashatan, Ahmadi, Abbaszadeh, & Rezaei‐Tavirani, ; Pannu & Bhatnagar, ). Good bioavailability and pharmacokinetic are critical for the early screening of various compounds in wine.…”

Section: Introductionmentioning

confidence: 99%

Systematic Analysis of the Pharmacological Effects of Alcoholic Components in Maotai

Zhou

Chen

Bao

et al. 2019

Journal of Food Science

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Maotai liquor is one of the most famous traditional Chinese distilled liquor enjoyed by many people all over the world for its unique production method, impressive liquor quality, and soy sauce‐like and roasted aroma style. It is known that aroma characteristics of liquor mainly depend on the aroma compounds. Alcohols as one of the most important categories of aroma components have been determined in Maotai liquor. However, the systemic analysis of alcoholic compounds in liquor is limited, especially the active alcoholic components and their pharmacological effects. Therefore, in this study, a systemic analysis method was proposed by combining in silico absorption, distribution, metabolism, and excretion (ADME) evaluation, target fishing, network pharmacology technology, pathway analysis, and experimental verification to interpret the pharmacological mechanism of alcoholic compounds in Maotai liquor. Finally, 15 compounds with favorable pharmacokinetic profiles were screened through in silico ADME models. Thirty‐eight related targets of these active compounds were identified by target prediction method. The network pharmacology and pathway analysis were developed to clarify the pharmacological effect of alcoholic compounds in Maotai liquor at the system and pathway level. Moreover, the key active compounds were validated by in vitro experiments that verified the effectiveness of our methods. Our study provides a novel approach to systematically analyze the pharmacological effect of alcoholic compounds in Maotai liquor, which would be beneficial for promoting the in‐depth study of various liquors. Practical Application Maotai liquor is popularly enjoyed in the world for a very long time. However, the systemic analysis of compounds in liquor is limited. Our systematic analysis approach was developed to explore the bioactive ingredients and their related target proteins as well as the pharmacological effects of Maotai liquor. This will provide a new method to understand the pharmacological mechanisms of compounds in various liquors at the systems level, so as to promote the development of liquors and to increase the public awareness of science about alcohol consumption.

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Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases

Cited by 188 publications

References 161 publications

Altered mitochondrial metabolism in the insulin‐resistant heart

Altered mitochondrial metabolism in the insulin‐resistant heart

PGC‐1α, a potential therapeutic target against kidney aging

Systematic Analysis of the Pharmacological Effects of Alcoholic Components in Maotai

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