Resveratrol Functionalized Carboxymethyl-<i>β</i>-Cyclodextrin: Synthesis, Characterization, and Photostability

Cheng, Jin Gui; Tian, Bingren; Huang, Qing Xue; Ge, Hu Rong; Wang, Zhizhong

doi:10.1155/2018/6789076

Cited by 19 publications

(11 citation statements)

References 33 publications

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“…Cheng et al . successfully modified resveratrol with cyclodextrin and explored the photo‐stability of the derivative; the results showed that the method could enhance the photo‐stability of resveratrol . When resveratrol formed inclusion complexes with different cyclodextrin, its stability was enhanced .…”

Section: Stabilitymentioning

confidence: 99%

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

2019

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Resveratrol, a stilbene molecule belonging to the polyphenol family, is usually extracted from a great many natural plants. The technologies of preparation and extraction methods are developing rapidly. As resveratrol has many beneficial properties, it has been widely utilized in food and medicine industry. In terms of its structure, it is susceptible to degradation and can undergo chemical changes during food processing. Different studies have therefore given more attention to various aspects of resveratrol, including anti-aging, anti-oxidant, and anti-cancer activity. This review classifies the study of resveratrol, considers plant sources, synthesis, stability, common reactions, and food applications, and provides references to boost its food and medical utilization. SYNTHESISSince the discovery of natural resveratrol by researchers, chemist have made many attempts at the chemical synthesis / biosynthesis of resveratrol (Fig. 2). 15

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Section: Stabilitymentioning

confidence: 99%

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

2019

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“…The complex formation between resveratrol and sulfobutylether-β-CD significantly increased the water solubility of resveratrol while loading them into polymeric nanoparticles [ 78 ]. The resveratrol solubility improved due to its complexation with permethylated β-CD, 2,6-dimethylated β-CD and permethylated α-CD [ 79 ] and the photostability was achieved because of its complexation with carboxymethyl-β-CD [ 80 ]. By using a cyclodextrin glucanotransferase enzyme, resveratrol α-glycosides were synthesized directly from β-CD-resveratrol complexes in water.…”

Section: Bioavailability Of Resveratrolmentioning

confidence: 99%

Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability

et al. 2021

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Resveratrol is a phytoalexin produced by many plants as a defense mechanism against stress-inducing conditions. The richest dietary sources of resveratrol are berries and grapes, their juices and wines. Good bioavailability of resveratrol is not reflected in its high biological activity in vivo because of resveratrol isomerization and its poor solubility in aqueous solutions. Proteins, cyclodextrins and nanomaterials have been explored as innovative delivery vehicles for resveratrol to overcome this limitation. Numerous in vitro and in vivo studies demonstrated beneficial effects of resveratrol in cardiovascular diseases (CVD). Main beneficial effects of resveratrol intake are cardioprotective, anti-hypertensive, vasodilatory, anti-diabetic, and improvement of lipid status. As resveratrol can alleviate the numerous factors associated with CVD, it has potential as a functional supplement to reduce COVID-19 illness severity in patients displaying poor prognosis due to cardio-vascular complications. Resveratrol was shown to mitigate the major pathways involved in the pathogenesis of SARS-CoV-2 including regulation of the renin-angiotensin system and expression of angiotensin-converting enzyme 2, stimulation of immune system and downregulation of pro-inflammatory cytokine release. Therefore, several studies already have anticipated potential implementation of resveratrol in COVID-19 treatment. Regular intake of a resveratrol rich diet, or resveratrol-based complementary medicaments, may contribute to a healthier cardio-vascular system, prevention and control of CVD, including COVID-19 disease related complications of CVD.

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“…The complex formation between resveratrol and sulfobutylether-β-CD significantly increased the water solubility of resveratrol while loading them into polymeric nanoparticles [78]. The resveratrol solubility improved due to its complexation with permethylated β-CD, 2,6-dimethylated β-CD and permethylated α-CD [79] and the photostability was achieved because of its complexation with carboxymethylβ-CD [80]. By using cyclodextrin glucanotransferase enzyme, resveratrol α-glycosides were synthesized directly from β-CD-resveratrol complexes in water.…”

Section: Application Of Cyclodextrins In Resveratrol Deliverymentioning

confidence: 99%

Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to Covid-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability

Gligorijević¹,

Stanić-Vučinić²,

Radomirović³

et al. 2021

Preprint

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Resveratrol is a phytoalexin produced by many plants as a defense mechanism against stress-inducing conditions. The richest dietary sources of resveratrol are berries and grapes, their juices and wines. Good bioavailability of resveratrol is not reflected in its high biological activity in vivo because of resveratrol isomerization and its poor solubility in aqueous solutions. Proteins, cyclodextrins and nanomaterials have been explored as innovative delivery vehicles for resveratrol to overcome this limitation. Numerous in vitro and in vivo studies demonstrated beneficial effects of resveratrol in cardiovascular diseases (CVD). Main beneficial effects of resveratrol intake are cardioprotective, anti-hypertensive, vasodilatory, anti-diabetic, and improvement of lipid status. As resveratrol can alleviate the numerous factors associated with CVD, it has potential as a functional supplement to reduce COVID-19 illness severity in patients displaying poor prognosis due to cardio-vascular complications. Resveratrol was shown to mitigate the major pathways involved in the pathogenesis of SARS-CoV-2 including regulation of the renin-angiotensin system and expression of angiotensin-converting enzyme 2, stimulation of immune system and downregulation of pro-inflammatory cytokines release. Therefore, several studies already have anticipated potential implementation of resveratrol in COVID-19 treatment. Regular intake of resveratrol rich diet, or resveratrol-based complementary medicaments, may contribute to a healthier cardio-vascular system, prevention and control of CVD, including COVID-19 disease related complications of CVD.

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Resveratrol Functionalized Carboxymethyl-β-Cyclodextrin: Synthesis, Characterization, and Photostability

Cited by 19 publications

References 33 publications

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability

Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to Covid-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability

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