Resveratrol in the treatment of pancreatic cancer

Xu, Qinhong; Zong, Liang; Chen, Xin; Jiang, Zhengdong; Nan, Ligang; Li, Jiahui; Duan, Wanxing; Liu, Jing; Zhang, Lun; Ma, Jiguang; Li, Xuqi; Wang, Zheng; Wu, Zheng; Ma, Qingyong; Ma, Zhenhua

doi:10.1111/nyas.12837

Cited by 63 publications

(46 citation statements)

References 69 publications

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“…Resveratrol is a natural polyphenolic phytoalexin that is widely found in plants and in traditional Chinese medicines [16,17]. Resveratrol has been shown to directly inhibit the proliferation and viability of human pancreatic cancer cells in vitro in a dose- and time-dependent manner [22].…”

Section: Discussionmentioning

confidence: 99%

“…Since then, resveratrol has been widely found in plants (such as grape skin, red wine, berries, and peanuts) and in traditional Chinese medicines (such as Rheum officinale Baill and Polygonum cuspidatum) [16,17]. Numerous studies have shown that resveratrol exhibits antioxidant activity, anti-inflammatory activity, and protective activity against cardiac diseases and metabolic disorders [18].…”

Section: Introductionmentioning

confidence: 99%

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YAP Inhibition by Resveratrol via Activation of AMPK Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine

Jiang

Chen

et al. 2016

Nutrients

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Resveratrol, a natural polyphenol present in most plants, inhibits the growth of numerous cancers both in vitro and in vivo. Aberrant expression of YAP has been reported to activate multiple growth-regulatory pathways and confer anti-apoptotic abilities to many cancer cells. However, the role of resveratrol in YES-activated protein (YAP) expression and that of YAP in pancreatic cancer cells’ response to gemcitabine resistance remain elusive. In this study, we found that resveratrol suppressed the proliferation and cloning ability and induced the apoptosis of pancreatic cancer cells. These multiple biological effects might result from the activation of AMP-activation protein kinase (AMPK) (Thr172) and, thus, the induction of YAP cytoplasmic retention, Ser127 phosphorylation, and the inhibition of YAP transcriptional activity by resveratrol. YAP silencing by siRNA or resveratrol enhanced the sensitivity of gemcitabine in pancreatic cancer cells. Taken together, these findings demonstrate that resveratrol could increase the sensitivity of pancreatic cancer cells to gemcitabine by inhibiting YAP expression. More importantly, our work reveals that resveratrol is a potential anticancer agent for the treatment of pancreatic cancer, and YAP may serve as a promising target for sensitizing pancreatic cancer cells to chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

YAP Inhibition by Resveratrol via Activation of AMPK Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine

Jiang

Chen

et al. 2016

Nutrients

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“…In addition, the enriched KEGG pathways derived from resveratrol gene sets also discovered 10 genes, CREBBP, HSP90B1, CTNNB1, PTEN, NFKBIA, TP53, HSP90AA1, CDKN1A, RELA and TCF7L2 (EntrezGene ID: 1387, 7184, 1499, 5728, 4792, 7157, 3320, 1026, 5970 and 6934), all associated with prostate cancer (Table 3). It is noteworthy that anti-carcinogenic properties of resveratrol have been observed in other solid tumors including the highly fatal pancreatic cancer [18, 19]. Evidence has also been garnered recently that resveratrol demonstrates efficacy in the treatment of inflammation-induced pancreatitis [20, 21].…”

Section: Resultsmentioning

confidence: 99%

Functional/activity network (FAN) analysis of gene-phenotype connectivity liaised by grape polyphenol resveratrol

Hsieh

Bennett

et al. 2016

Oncotarget

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Resveratrol is a polyphenol that has witnessed an unprecedented yearly growth in PubMed citations since the late 1990s. Based on the diversity of cellular processes and diseases resveratrol reportedly affects and benefits, it is likely that the interest in resveratrol will continue, although uncertainty regarding its mechanism in different biological systems remains.We hypothesize that insights on disease-modulatory activities of resveratrol might be gleaned by systematically dissecting the publicly available published data on chemicals and drugs. In this study, we tested our hypothesis by querying DTome (Drug-Target Interactome), a web-based tool containing data compiled from open-source databases including DrugBank, PharmGSK, and Protein Interaction Network Analysis (PINA). Four direct protein targets (DPT) and 219 DPT-associated genes were identified for resveratrol. The DPT-associated genes were scrutinized by WebGestalt (WEB-based Gene SeT Analysis Toolkit). This enrichment analysis resulted in 10 identified KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways. Refined analysis of KEGG pathways showed that 2 — one linked to p53 and a second to prostate cancer — have functional connectivity to resveratrol and its four direct protein targets. These results suggest that a functional activity network (FAN) approach may be considered as a new paradigm for guiding future studies of resveratrol. FAN analysis resembles a BioGPS, with capability for mapping a Web-based scientific track that can productively and cost effectively connect resveratrol to its primary and secondary target proteins and to its biological functions.

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“…RES inhibited proliferation, invasion and metastasis and induced apoptosis in pancreatic cancer cells and suppressed proliferation and viability of pancreatic CSCs. RES also could chemosensitize pancreatic cancer cells and have effects on diabetes [87]. …”

Section: Introductionmentioning

confidence: 99%

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

McCubrey¹,

Lertpiriyapong²,

Steelman³

et al. 2017

aging

195

128

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Natural products or nutraceuticals have been shown to elicit anti-aging, anti-cancer and other health-enhancing effects. A key target of the effects of natural products may be the regulation of microRNA (miR) expression which results in cell death or prevents aging, diabetes, cardiovascular and other diseases. This review will focus on a few natural products, especially on resveratrol (RES), curcumin (CUR) and berberine (BBR). RES is obtained from the skins of grapes and other fruits and berries. RES may extend human lifespan by activating the sirtuins and SIRT1 molecules. CUR is isolated from the root of turmeric (Curcuma longa). CUR is currently used in the treatment of many disorders, especially in those involving an inflammatory process. CUR and modified derivatives have been shown to have potent anti-cancer effects, especially on cancer stem cells (CSC). BBR is also isolated from various plants (e.g., Coptis chinensis) and has been used for centuries in traditional medicine to treat diseases such as adult- onset diabetes. Understanding the benefits of these and other nutraceuticals may result in approaches to improve human health.

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Resveratrol in the treatment of pancreatic cancer

Cited by 63 publications

References 69 publications

YAP Inhibition by Resveratrol via Activation of AMPK Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine

YAP Inhibition by Resveratrol via Activation of AMPK Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine

Functional/activity network (FAN) analysis of gene-phenotype connectivity liaised by grape polyphenol resveratrol

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

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