Resveratrol increases tear production and ocular pain after corneal abrasion in male, but not female, rats using a photorefractive keratectomy model

Hegarty, Deborah M.; Carroll, J. Douglas; Nguyen, Dennis C.; Halls, Victoria S.; Price, Theodore J.; Dussor, Gregory; Aicher, Sue A.

doi:10.1016/j.exer.2022.109281

Cited by 3 publications

(2 citation statements)

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“…However, clinical studies on post‐PRK pain and other vision correction procedures indicate they may cause acute pain, increased light sensitivity (photophobia), and diminished tear production. In an attempt to accurately mimic common postoperative symptoms, Hegarty et al (2022) devised a corneal abrasion model by debriding the corneal epithelium and severing corneal sensory nerves in the abraded area. This model was employed to assess whether resveratrol could mitigate adverse postoperative reactions.…”

Section: Resveratrol: a Possible Solution For Postoperative Pain And ...mentioning

confidence: 99%

“…This model was employed to assess whether resveratrol could mitigate adverse postoperative reactions. WhileHegarty et al (2022) found that topical resveratrol may not be especially effective in addressing PRK-induced pain, its high lipophilicity and limited systemic bioavailability render it ideal for local or topical applications. Notably, resveratrol was found to significantly augment tear secretion in male rats.…”

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confidence: 99%

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Deciphering resveratrol's role in modulating pathological pain: From molecular mechanisms to clinical relevance

Wang,

Jiang,

et al. 2023

Phytotherapy Research

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Pathological pain, a multifaceted and debilitating ailment originating from injury or post‐injury inflammation of the somatosensory system, poses a global health challenge. Despite its ubiquity, reliable therapeutic strategies remain elusive. To solve this problem, resveratrol, a naturally occurring nonflavonoid polyphenol, has emerged as a potential beacon of hope owing to its anti‐inflammatory, antioxidant, and immunomodulatory capabilities. These properties potentially position resveratrol as an efficacious candidate for the management of pathological pain. This concise review summaries current experimental and clinical findings to underscore the therapeutic potential of resveratrol in pathological pain, casting light on the complex underlying pathophysiology. Our exploration suggests that resveratrol may exert its analgesic effect by the modulating pivotal signaling pathways, including PI3K/Akt/mTOR, TNFR1/NF‐κB, MAPKs, and Nrf2. Moreover, resveratrol appears to attenuate spinal microglia activation, regulate primary receptors in dorsal root sensory neurons, inhibit pertinent voltage‐gated ion channels, and curb the expression of inflammatory mediators and oxidative stress responses. The objective of this review is to encapsulate the pharmacological activity of resveratrol, including its probable signaling pathways, pharmacokinetics, and toxicology pertinent to the treatment of pathological pain. Hopefully, we aim to map out promising trajectories for the development of resveratrol as a potential analgesic.

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Section: Resveratrol: a Possible Solution For Postoperative Pain And ...mentioning

confidence: 99%

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confidence: 99%