Resveratrol-induced gut microbiota reduces obesity in high-fat diet-fed mice

Wang, Pan; Li, Daotong; Ke, Weixin; Li, Dong; Hu, Xiaosong; Chen, Fang

doi:10.1038/s41366-019-0332-1

Cited by 236 publications

(164 citation statements)

References 64 publications

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“…Furthermore, these changes of microbial composition influenced by butyrate have significant functional implications as indicated in Spearman correlation analysis (Figure S4). The above‐mentioned genera are highly correlated with expression levels of lipid and/or glucose metabolic genes, which is in agreement with earlier findings showing their involvement in lipid/glucose metabolism (Martínez et al, ; Wang et al, ; Zhu et al, ). Microbiota‐derived metabolite TMAO was reported to profoundly modulate atherosclerosis by impairing RCT and inducing the formation of foam cells (Koeth et al, ).…”

Section: Discussionsupporting

confidence: 91%

Butyrate protects against high‐fat diet‐induced atherosclerosis via up‐regulating ABCA1 expression in apolipoprotein E‐deficiency mice

et al. 2020

British J Pharmacology

111

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Background and Purpose The gut microbial metabolite butyrate is linked to the modulation of metabolic disease. The mechanism by which butyrate effects in atherosclerosis is unknown. Hence, the present investigation into effects of butyrate on high‐fat diet‐fed ApoE−/− mice after 16 weeks' administration. Experimental Approach Gut microbiota composition was analysed via 16S rRNA gene sequencing of caecal contents. The effects of butyrate on atherosclerosis were evaluated in vivo using the ApoE−/− mice model. Serum lipids and glucose were analysed for physiological changes and differentially expressed genes in liver samples were identified by hepatic transcriptome profiling. The proteins involved in reverse cholesterol transport were quantified by Western blot and immunohistochemical staining. Finally, the up‐regulatory effects of butyrate on ATP‐binding cassette sub‐family A member 1 (ABCA1) were further evaluated in RAW 264.7 cells along with role of specificity protein 1 by inhibition and silencing. Key Results Oral gavage of butyrate altered microbiota composition and enhanced gut microbial diversity that was decreased by high fat diet (HFD). Butyrate treatment significantly inhibited the HFD‐induced atherosclerosis as well as hepatic steatosis without changing body weight gain in ApoE−/− mice. Butyrate had metabolic effects on the liver by regulation of gene expression involved in lipid/glucose metabolism. Furthermore, ABCA1 was significantly induced by butyrate in vivo, ex vivo and in vitro and Sp1 pathway was identified as a potential mechanism. Conclusion and Implications Butyrate ameliorates HFD‐induced atherosclerosis in ApoE−/− mice via ABCA1‐mediated cholesterol efflux in macrophages, which suggesting a promising therapeutic strategy for protecting against atherosclerosis.

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Section: Discussionsupporting

confidence: 91%

Butyrate protects against high‐fat diet‐induced atherosclerosis via up‐regulating ABCA1 expression in apolipoprotein E‐deficiency mice

et al. 2020

British J Pharmacology

111

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“…For example, Odoribacter and Cyanobacteria are positively associated with stress in mice and pigs [30,31]. Ruminiclostridium 9 increased in obese rodents [32]. Prevotellaceae_UCG-001 is a well-known bacteria degrading mucus oligosaccharides in the intestine, leading to a smaller mucin layer and the onset of intestinal inflammation in rodents [33].…”

Section: Pathogenic Bacteriamentioning

confidence: 99%

Residual feed intake divergence during the preweaning period is associated with unique hindgut microbiome and metabolome profiles in neonatal Holstein heifer calves

Elolimy

Alharthi

Zeineldin

et al. 2020

J Animal Sci Biotechnol

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Background: Recent studies underscored that divergence in residual feed intake (RFI) in mature beef and dairy cattle is associated with changes in ruminal microbiome and metabolome profiles which may contribute, at least in part, to better feed efficiency. Because the rumen in neonatal calves during the preweaning period is underdeveloped until close to weaning, they rely on hindgut microbial fermentation to breakdown undigested diet components. This leads to production of key metabolites such as volatile fatty acids (VFA), amino acids, and vitamins that could potentially be absorbed in the hind-gut and help drive growth and development. Whether RFI divergence in neonatal calves is associated with changes in hindgut microbial communities and metabolites is largely unknown. Therefore, the objective of the current study was to determine differences in hindgut microbiome and metabolome in neonatal Holstein heifer calves retrospectively-grouped based on feed efficiency as mostefficient (M-eff) or least-efficient (L-eff) calves using RFI divergence during the preweaning period. Methods: Twenty-six Holstein heifer calves received 3.8 L of first-milking colostrum from their respective dams within 6 h after birth. Calves were housed in individual outdoor hutches bedded with straw, fed twice daily with a milk replacer, and had ad libitum access to a starter grain mix from birth to weaning at 42 d of age. Calves were classified into M-eff [n = 13; RFI coefficient = − 5.72 ± 0.94 kg DMI (milk replacer + starter grain)/d] and L-eff [n = 13; RFI coefficient = 5.61 ± 0.94 kg DMI (milk replacer + starter grain)/d] based on a linear regression model including the combined starter grain mix and milk replacer DMI, average daily gain (ADG), and metabolic body weight (MBW). A deep sterile rectal swab exposed only to the rectum was collected immediately at birth before colostrum feeding (i.e., d 0), and fecal samples at d 14, 28, and 42 (prior to weaning) for microbiome and untargeted metabolome analyses using 16S rRNA gene sequencing and LC-MS. Microbiome data were analyzed with the QIIME 2 platform and metabolome data with the MetaboAnalyst 4.0 pipeline.

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“…Besides its multiple benefits to host health, such as antioxidation and anti-inflammation, resveratrol potentially alters the composition of gut microbiota to ameliorate adiposity and improve glucose homeostasis in HFD-fed mice (Qiao et al, 2014;Sung et al, 2017). Wang et al (2020) confirmed the effect of resveratrol-induced gut microbiota by transplanting the microbiota from donors treated with a resveratrol diet for 16 weeks to the HFD-fed mice. They found that the recipient mice showed decreased body weight and improved insulin resistance.…”

Section: Signals That Mediate the Crosstalk Between Microbiota And Homentioning

confidence: 83%

The Role of the Gut Microbiome in Energy Balance With a Focus on the Gut-Adipose Tissue Axis

Han

Kang

2020

Front. Genet.

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Obesity is a complex disease attributable to many factors including genetics and environmental influences. Growing evidence suggests that gut microbiota is a major contributing factor to the pathogenesis of obesity and other metabolic disorders. This article reviews the current understanding of the role of gut microbiota in the regulation of energy balance and the development of obesity, and how the microbiota communicates with host tissues, in particular adipose tissue. We discuss several external factors that interfere with the interplay between gut microbiota and host tissue metabolism, including cold exposure, diet regimens, and genetic manipulations. We also review the role of dietderived metabolites that regulate thermogenesis and thus energy homeostasis. Among the gut microbial metabolites, we emphasize short-chain fatty acids, which could be utilized by the host as a direct energy source while regulating the appetite of the host through the gut-brain axis.

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Resveratrol-induced gut microbiota reduces obesity in high-fat diet-fed mice

Cited by 236 publications

References 64 publications

Butyrate protects against high‐fat diet‐induced atherosclerosis via up‐regulating ABCA1 expression in apolipoprotein E‐deficiency mice

Butyrate protects against high‐fat diet‐induced atherosclerosis via up‐regulating ABCA1 expression in apolipoprotein E‐deficiency mice

Residual feed intake divergence during the preweaning period is associated with unique hindgut microbiome and metabolome profiles in neonatal Holstein heifer calves

The Role of the Gut Microbiome in Energy Balance With a Focus on the Gut-Adipose Tissue Axis

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