Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR-21 regulation of BCL-2 expression

Liu, P.; Liang, Hongbin; Xia, Qianfeng; Li, P.; Kong, Hainan; Lei, Pingchong; Wang, S.; Tu, Zhiguang

doi:10.1007/s12094-012-0999-4

Cited by 119 publications

(73 citation statements)

References 19 publications

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“…68,69 In PDAC, BCL2 is overexpressed through the effects of miR-21, which leads to an enhanced anti-apoptotic effect. 70,71 BCL2 is targeted by miR-181b, and the inhibition of BCL2 expression following miR-181b transfection reduces gemcitabine resistance. 72 Programmed cell death 4 (PDCD4) is a tumour suppressor that regulates multiple proteins involved in tumour progression, cell cycle control and differentiation and may be regulated by miR-21 in PDAC, miRNAs in PDACs K Yonemori et al potentially leading to cell death and poor prognosis.…”

Section: Apoptosismentioning

confidence: 99%

MicroRNA in pancreatic cancer

2016

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Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. Patients with PDAC are often asymptomatic, and many have lymph node and distant metastases as well as vessel invasion upon diagnosis. Surgery and current chemotherapy have limited efficacy for improving prognosis, which accounts for overall median survival of 8.6 months and a 9.7% 5-year survival rate. MicroRNAs (miRNAs) are attracting increasing attention because of their association with tumour progression. At least 50% of miRNAs that are aberrantly expressed in tumours have important roles as post-transcriptional regulators and exhibit oncogenic or tumour suppressive activities by directly binding to their target messenger RNAs. Various techniques are available to identify miRNAs that are differentially expressed in cancerous vs normal tissues. In this review, we summarise the miRNA profiles of normal pancreatic tissue and cancer tissue of patients with PDACs and characterise the expression of miRNAs associated with tumour progression. Further, we highlight the target genes and signalling pathways of miRNAs that are aberrantly expressed in PDACs. This knowledge may lead to the development of preventive and therapeutic strategies for treating this deadly disease.

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Section: Apoptosismentioning

confidence: 99%

MicroRNA in pancreatic cancer

2016

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“…Functional studies have revealed that miR-21 is an oncogene, which is important in enhancing cell proliferation, promoting cell cycle progression and increasing anti-apoptotic activation in cancer cells (12). In numerous cancer cell lines, miR-21 was demonstrated to be the therapeutic target of resveratrol (13,14). Of note, miR-21 was significantly upregulated in advanced bladder cancer tissues and the overexpression of miR-21 promoted the proliferation of bladder cancer cell lines (15).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol induces apoptosis of bladder cancer cells via miR-21 regulation of the Akt/Bcl-2 signaling pathway

Zhou

Ding

2014

Molecular Medicine Reports

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Abstract. Resveratrol, an edible polyphenolic phytoalexin present in grapes and red wine, has been reported to inhibit proliferation and induce apoptosis of bladder cancer cells. In the present study, the molecular mechanisms of resveratrol on human bladder cancer cell apoptosis was examined. The effect of resveratrol on the viability and apoptosis of T24 and 5637 cells was measured using an MTT assay and flow cytometric analysis, respectively. Next, the effect of resveratrol on miR-21 expression was detected by real-time PCR. The expression of phospho-Akt and Bcl-2 following treatment with resveratrol or the downregulation of miR-21 expression were also measured. Resveratrol induced the cytotoxicity and apoptosis of T24 and 5637 cells in a dose-dependent manner. Resveratrol decreased the expression of miR-21, the level of phospho-Akt and Bcl-2 protein expression. In addition, the downregulation of miR-21 expression inhibited the level of phospho-Akt and Bcl-2 expression. Insulin-like growth factor-1 was able to reverse the effect of the miR-21 inhibitor on Bcl-2 expression and apoptosis in T24 and 5637 cells. Notably, overexpression of miR-21 expression was able to restore the inhibition of Akt activity, downregulation of Bcl-2 expression and apoptosis induced by resveratrol. Collectively, data revealed that the effect of resveratrol on bladder cancer cell apoptosis was due to miR-21 regulation of the Akt/Bcl-2 signaling pathway.

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“…On the other hand, it was illustrated that resveratrol downregulates miR-21 in pancreatic cancer cell lines such as PANC-1, CFPAC-1, and MIA Paca-2. It causes inhibition of Bcl-2 expression; hence, the upregulation of miR-21 modulates Bcl-2 expression and induced apoptosis (Liu et al 2013). Vislovukh et al (2013) noted that resveratrol • Downregulated miR-221 and miR-222 Chen et al (2011) upregulated two miRNAs in MCF-7 breast adenocarcinoma cells namely miR-663 and miR-774.…”

Section: Anticancer Agents From Naturementioning

confidence: 99%

Can the chemotherapeutic agents perform anticancer activity though miRNA expression regulation? Proposing a new hypothesis

et al. 2015

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In the recent advancement of cancer therapy, mortality of the immortal cancer cells begins to decline, and it shows great promise for the chemotherapy regimen supported by targeted therapy. In this post-genomic era boosted by the discovery of microRNA (miRNA), it has been understood that miRNA regulates gene expression at the post-transcriptional level. On the other hand, some studies have also indicated that miRNA expression level has changed during the treatment of chemotherapy. Data based on various previous studies, we propose that the chemotherapeutic agents modulate miRNA expression that might perform anticancerous activities through cellular changes such as DNA repair, cell cycle arrest, or apoptosis.

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Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR-21 regulation of BCL-2 expression

Abstract: In this study, we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression.

Cited by 119 publications

References 19 publications

MicroRNA in pancreatic cancer

MicroRNA in pancreatic cancer

Resveratrol induces apoptosis of bladder cancer cells via miR-21 regulation of the Akt/Bcl-2 signaling pathway

Can the chemotherapeutic agents perform anticancer activity though miRNA expression regulation? Proposing a new hypothesis

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