Resveratrol Influences Pancreatic Islets by Opposing Effects on Electrical Activity and Insulin Release

Brouwer, Simone; Hoffmeister, Theresa; Gresch, Anne; Schönhoff, Lisa; Düfer, Martina

doi:10.1002/mnfr.201700902

Cited by 10 publications

(10 citation statements)

References 41 publications

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“…In the following paragraphs, all of the selected nutraceuticals have a positive effect on insulin secretion or pancreatic protection, mainly including polyphenols (resveratrol, [6]-gingerol, and curcumin), flavonoids (genistein), polysaccharides (7WA and fucoidan), triterpenoid (oleanolic acid), and alkaloid (coixol) (Table 1). Previous studies have reported that resveratrol has the ability to reduce blood glucose and improve insulin sensitivity by preventing the degradation of cAMP [43,44]. Additionally, a recent study reported that daily orally administration of [6]-gingerol for 28 days for db/db mice significantly increases glucose-stimulated insulin secretion and enhances glucose tolerance.…”

Section: The Dietary Bioactive Ingredients Targeting Pancreas Camp Signaling For Glucose Homeostasismentioning

confidence: 99%

“…Previous studies have reported that resveratrol has the ability to reduce blood glucose and improve insulin sensitivity by preventing the degradation of cAMP [ 43 , 44 ]. Additionally, a recent study reported that daily orally administration of [6]-gingerol for 28 days for db/db mice significantly increases glucose-stimulated insulin secretion and enhances glucose tolerance.…”

Section: Pancreasmentioning

confidence: 99%

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Dietary Bioactive Ingredients Modulating the cAMP Signaling in Diabetes Treatment

Wang

Liu²,

Kang

et al. 2021

Nutrients

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As the prevalence of diabetes increases progressively, research to develop new therapeutic approaches and the search for more bioactive compounds are attracting more attention. Over the past decades, studies have suggested that cyclic adenosine monophosphate (cAMP), the important intracellular second messenger, is a key regulator of metabolism and glucose homeostasis in diverse physiopathological states in multiple organs including the pancreas, liver, gut, skeletal muscle, adipose tissues, brain, and kidney. The multiple characteristics of dietary compounds and their favorable influence on diabetes pathogenesis, as well as their intersections with the cAMP signaling pathway, indicate that these compounds have a beneficial effect on the regulation of glucose homeostasis. In this review, we outline the current understanding of the diverse functions of cAMP in different organs involved in glucose homeostasis and show that a diversity of bioactive ingredients from foods activate or inhibit cAMP signaling, resulting in the improvement of the diabetic pathophysiological process. It aims to highlight the diabetes-preventative or -therapeutic potential of dietary bioactive ingredients targeting cAMP signaling.

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Section: The Dietary Bioactive Ingredients Targeting Pancreas Camp Signaling For Glucose Homeostasismentioning

confidence: 99%

Section: Pancreasmentioning

confidence: 99%

Dietary Bioactive Ingredients Modulating the cAMP Signaling in Diabetes Treatment

Wang

Liu²,

Kang

et al. 2021

Nutrients

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“…Resveratrol (trans‐3,4,5‐trihydroxy‐stilbene; RE), a traditional Chinese medicine, is known as a naturally occurring compound with potent biological properties . It is found in plants, such as grapes, giant knotweed, peanuts and mulberries .…”

Section: Introductionmentioning

confidence: 99%

Resveratrol promotes trophoblast invasion in pre‐eclampsia by inducing epithelial‐mesenchymal transition

Zou

et al. 2019

J Cellular Molecular Medi

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Impairment spiral arteries remodelling was considered to be the underlying cause of pathogenesis of pre‐eclampsia (PE). Resveratrol (RE) was reported that it could modulate cellar phenotype to ameliorate diverse human diseases. However, the biological function of RE in PE remains poorly understood. In this report, we investigated the effect of RE on trophoblast phenotype both in vivo and in vitro. We conducted MTT and transwell assays to explore cell proliferation and invasion events in HTR‐8/SVneo. In mice model, the clinical characteristics of PE were established through the injection of NG‐nitro‐ l ‐arginine methyl ester (L‐NAME). Furthermore, related experiments were performed to detect cellar phenotype‐associated signalling pathway, including epithelial‐mesenchymal transition (EMT) and Wnt/β‐catenin. Cell assays indicated that RE could increase trophoblasts migration and invasion. In addition, hypertension and proteinuria were markedly ameliorated by RE compared with the controls in PE mice model. Moreover, treatment by RE in trophoblasts or in PE model, we found that RE activated EMT progress through the regulation of E‐cadherin, β‐catenin, N‐cadherin, vimentin expression, and further altered the WNT‐related gene expression, including WNT1, WNT3 and WNT5B. Our findings demonstrated that RE might stimulate the invasive capability of human trophoblasts by promoting EMT and mediating the Wnt/β‐catenin pathway in PE.

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“…In a recent study, it has been reported that the multiple aspects of the action of RSV on the mechanisms control glucose homeostasis [61]. Polyphenol plays a protective role on pancreatic islets by increasing the synthesis of antioxidant enzymes, such as superoxide dismutase, glutathione peroxidase, and glutathione-s-transferase, which counteract the action of free radicals [62]. The antiapoptotic power toward β-cells has emerged both in animal models with streptozotocin toxic damage and in the autoimmune insulin of type 1 diabetes mellitus, where the action of RSV manifests itself by reducing the expression of the chemokine receptor 6 and inhibiting the migration of inflammatory cells into the pancreas [63,64].…”

Section: Diabetesmentioning

confidence: 99%

Protective Activity of Resveratrol in Cardio- and Cerebrovascular Diseases

Carrizzo¹,

Izzo²,

Vecchione³

2019

Resveratrol - Adding Life to Years, Not Adding Years to Life

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Resveratrol (RSV) is a natural nonflavonoid polyphenol compound containing a stilbene structure similar to that of estrogen diethylstilbestrol. It is a fat-soluble compound existing in cis-, trans-, and piceid isomeric forms, isolated for the first time in 1940 from a plant used in traditional Chinese and Japanese medicine. Although initially used for cancer therapy, it has shown beneficial effects against most cardiovascular and cerebrovascular diseases. Its beneficial effects are mainly related to its antioxidant properties. Here, we review the metabolism and the ability of RSV to modulate redox signaling and to interact with multiple molecular targets of different intracellular pathways exerting protective effects against cardio-cerebrovascular diseases and metabolic disorders such as diabetes, reporting evidence in animal models and its efficacy and toxicity in humans. The aim of this chapter is to highlight the mechanisms, the biology, and the potential use of resveratrol to prevent, protect and aid cardio-and cerebrovascular diseases.

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Resveratrol Influences Pancreatic Islets by Opposing Effects on Electrical Activity and Insulin Release

Cited by 10 publications

References 41 publications

Dietary Bioactive Ingredients Modulating the cAMP Signaling in Diabetes Treatment

Dietary Bioactive Ingredients Modulating the cAMP Signaling in Diabetes Treatment

Resveratrol promotes trophoblast invasion in pre‐eclampsia by inducing epithelial‐mesenchymal transition

Protective Activity of Resveratrol in Cardio- and Cerebrovascular Diseases

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