Resveratrol inhibiting TGF/ERK signaling pathway can improve atherosclerosis: backgrounds, mechanisms and effects

Guo, Shitian; Zhou, Yu; Xie, Xing

doi:10.1016/j.biopha.2022.113775

Cited by 27 publications

(16 citation statements)

References 113 publications

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“…Also, it inhibited the expression of matrix metalloproteinase-9, CD40 ligand (CD40L), and inflammatory factors [ 18 ]. Similarly, resveratrol regulated lipid metabolism and inhibited inflammation development through the TGF/ERK signaling pathway, playing a beneficial role in AS [ 21 ]. As shown in Figure 3(b) , the red cluster was the first dominant cluster of resveratrol and atherosclerosis (resveratrol, cardiovascular disease, atherosclerosis, coronary heart disease, and antioxidant) that were associated with resveratrol's role as an antioxidant in AS.…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Role and Potential Mechanism of Resveratrol in Atherosclerosis: TLR4/NF-κB/HIF-1α

Guo

Zhang

et al. 2023

Mediators of Inflammation

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Atherosclerosis, the main pathological basis of cardiovascular disease, is a chronic inflammatory disease that severely affects the quality of human life. Resveratrol (Res) is a natural polyphenol that is a major component of many herbs and foods. The present study analyzed resveratrol from the perspective of visualization and bibliometric analysis and found that resveratrol is closely related to the inflammatory response in cardiovascular diseases (associated with atherosclerosis). To explore the specific molecular mechanism of resveratrol, network pharmacology and Kyoto Encyclopedia of Genes and Genomes (KEGG) were used, in which HIF-1α signaling may be a key pathway in the treatment of AS. Furthermore, we induced the polarization of macrophage RAW264.7 to M1 type to generate inflammatory response by the combination of lipopolysaccharide (LPS) (200 ng/mL) + interferon-γ (IFN-γ) (2.5 ng/mL). LPS and IFN-γ increased the inflammatory factor levels of IL-1β, TNF-α, and IL-6 in RAW264.7, and the proportion of M1-type macrophages also increased, but the expression of inflammatory factors decreased after resveratrol administration, which confirmed the anti-inflammatory effect of resveratrol in AS. In addition, we found that resveratrol downregulated the protein expression of toll-like receptor 4 (TLR4)/NF-κB/hypoxia inducible factor-1 alpha (HIF-1α). In conclusion, resveratrol has a significant anti-inflammatory effect, alleviates HIF-1α-mediated angiogenesis, and prevents the progression of AS through the TLR4/NF-κB signaling pathway.

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Section: Resultsmentioning

confidence: 99%

Therapeutic Role and Potential Mechanism of Resveratrol in Atherosclerosis: TLR4/NF-κB/HIF-1α

Guo

Zhang

et al. 2023

Mediators of Inflammation

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“…ERK is integral to the uptake of ox-LDL by human macrophages ( Li et al, 2010 ). Resveratrol and Tribulus terrestris L. extract ameliorates atherosclerosis by inhibition of vascular smooth muscle cell proliferation in ApoE −/− mice via suppression of ERK signaling pathway ( Guo S. et al, 2022 ; Zhang et al, 2022 ). P38 MAPK signaling pathway activation is associated with the release of inflammatory cytokines, which also activates p38 MAPK in turn ( Voutyritsa et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of frog skin peptide temporin-1CEa and its analogs on ox-LDL induced macrophage-derived foam cells

et al. 2023

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Purpose: Atherosclerosis is one of the most important pathological foundations of cardiovascular and cerebrovascular diseases with high morbidity and mortality. Studies have shown that macrophages play important roles in lipid accumulation in the vascular wall and thrombosis formation in atherosclerotic plaques. This study aimed to explore the effect of frog skin antimicrobial peptides (AMPs) temporin-1CEa and its analogs on ox-LDL induced macrophage-derived foam cells.Methods: CCK-8, ORO staining, and intracellular cholesterol measurements were used to study cellular activity, lipid droplet formation and cholesterol levels, respectively. ELISA, real-time quantitative PCR, Western blotting and flow cytometry analysis were used to study the expression of inflammatory factors, mRNA and proteins associated with ox-LDL uptake and cholesterol efflux in macrophage-derived foam cells, respectively. Furthermore, the effects of AMPs on inflammation signaling pathways were studied.Results: Frog skin AMPs could significantly increase the cell viability of the ox-LDL-induced foaming macrophages and decrease the formation of intracellular lipid droplets and the levels of total cholesterol and cholesterol ester (CE). Frog skin AMPs inhibited foaming formation by reducing the protein expression of CD36, which regulates ox-LDL uptake but had no effect on the expression of efflux proteins ATP binding cassette subfamily A/G member 1 (ABCA1/ABCG1). Then, decreased mRNA expression of NF-κB and protein expression of p-NF-κB p65, p-IκB, p-JNK, p-ERK, p-p38 and the release of TNF-α and IL-6 occurred after exposure to the three frog skin AMPs.Conclusion: Frog skin peptide temporin-1CEa and its analogs can improve the ox-LDL induced formation of macrophage-derived foam cells, in addition, inhibit inflammatory cytokine release through inhibiting the NF-κB and MAPK signaling pathways, thereby inhibiting inflammatory responses in atherosclerosis.

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“…Pharmacological studies suggest that therapeutic doses of resveratrol are nontoxic and well-tolerated by humans. Although present in small amounts in many plant-based foods, nutritional supplements of resveratrol are often produced from the extraction of resveratrol from the dried roots of Polygonum cuspidatum, which has also been used in traditional Asian medicine to treat cardiovascular disorders [14]. Resveratrol is rapidly and efficiently absorbed following oral administration, though its bioavailability is low due to its metabolism to sulfated and glucuronidation derivatives during first-pass metabolism.…”

Section: Resveratrol Supplementsmentioning

confidence: 99%

Resveratrol Supplements Reduce the Risk of Aging-Related Cardiac Disease after Cardiorespiratory Fitness

Wu¹,

Zhu²,

Li³

et al. 2024

Resveratrol - Recent Advances, Application, and Therapeutic Potential

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Aging changes in the very elderly cardiac disease are associated with physiological and pathological changes, however, all observed changes in aging are associated with a deterioration of cardiorespiratory fitness function. For example, hypertension and cardiorespiratory disease make difficult distinctions between normal aging changes and the effects of underlying resveratrol supplements processes. Cardiorespiratory fitness-independent changes in resveratrol intake are still unclear. This review aimed to discuss whether the aging-associated cardiorespiratory fitness changes in the heart can be reversed by resveratrol supplements, and the mechanisms of cardiorespiratory fitness. Aging led to apoptosis and fibrosis-related protein expression increased, however, cardiorespiratory fitness had revered more functions. Resveratrol supplements in combination with cardiorespiratory fitness had a good enhanced mitochondrial function in aging including IL-6, STAT3, MEK5, and MEK1/ERK1 increased. Resveratrol supplements also induced survival signals and downregulation of apoptosis signaling in aging. Therefore, we suggest resveratrol has enhanced cardiorespiratory fitness to combine their function in repressed aging.

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Resveratrol inhibiting TGF/ERK signaling pathway can improve atherosclerosis: backgrounds, mechanisms and effects

Cited by 27 publications

References 113 publications

Therapeutic Role and Potential Mechanism of Resveratrol in Atherosclerosis: TLR4/NF-κB/HIF-1α

Therapeutic Role and Potential Mechanism of Resveratrol in Atherosclerosis: TLR4/NF-κB/HIF-1α

Effects of frog skin peptide temporin-1CEa and its analogs on ox-LDL induced macrophage-derived foam cells

Resveratrol Supplements Reduce the Risk of Aging-Related Cardiac Disease after Cardiorespiratory Fitness

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