Resveratrol inhibits fatty acid and triacylglycerol synthesis in rat hepatocytes

Gnoni, Gabriele V.; Paglialonga, G.

doi:10.1111/j.1365-2362.2008.02077.x

Cited by 61 publications

(34 citation statements)

References 40 publications

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“…Presumably, its inhibitory role in the late phase of adipogenesis is likely to be due to modulation of either lipogenesis or lipolysis. Although little is known about the role of piceatannol in lipid metabolism, resveratrol has been shown to inhibit total fatty acid and triglyceride synthesis in adipocytes (51,52). Current evidence also suggests a role for resveratrol in stimulating lipolysis and fatty acid oxidation in adipocytes (53)(54)(55).…”

Section: Discussionmentioning

confidence: 99%

Piceatannol, Natural Polyphenolic Stilbene, Inhibits Adipogenesis via Modulation of Mitotic Clonal Expansion and Insulin Receptor-dependent Insulin Signaling in Early Phase of Differentiation

Kwon

Seo

Heo

et al. 2012

Journal of Biological Chemistry

116

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Background: Adipogenesis contributes to the increase in adipose tissue mass. Results: Preadipocytes treated with piceatannol showed reduced adipogenesis with impairment of the early cell cycle progress and insulin-signaling pathway. Conclusion:The anti-adipogenic function of piceatannol is through inhibition of mitotic clonal expansion and insulin receptor activity in the early phase of adipogenesis. Significance: Piceatannol is a novel anti-adipogenic compound that could modulate development of adipose tissue.

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Section: Discussionmentioning

confidence: 99%

Piceatannol, Natural Polyphenolic Stilbene, Inhibits Adipogenesis via Modulation of Mitotic Clonal Expansion and Insulin Receptor-dependent Insulin Signaling in Early Phase of Differentiation

Kwon

Seo

Heo

et al. 2012

Journal of Biological Chemistry

116

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“…The observed effects were accompanied by the decreased 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase activity and reduced expression of its gene. In isolated hepatocytes, resveratrol decreased de novo synthesis of some fatty acids, reduced incorporation of acetate into triglycerides and decreased the activity of acetyl-CoA carboxylase; however, cholesterol synthesis and 3HMG-CoA reductase activity remained unchanged [12]. The studies performed by Barger et al [13] European Journal of Clinical Investigation Vol 39 899 DOI: 10.1111/j.1365-2362.2009.02188.x ORIGINAL ARTICLE revealed that even low doses of resveratrol provided in the diet can exert health protecting effects -the compound mimicked a calorie restriction inhibiting expression of genes engaged in cardiac and skeletal muscle ageing and increased insulin-stimulated glucose uptake.…”

Section: Introductionmentioning

confidence: 93%

The inhibitory effect of resveratrol on leptin secretion from rat adipocytes

Szkudelska

Nogowski

Szkudelski

2009

Eur J Clin Investigation

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Background Resveratrol was found to alleviate consequences of some metabolic disturbances which may be due to inappropriate dietary habits. It decreases mortality, increases insulin sensitivity and improves motor functions; these effects are accompanied by reduced plasma leptin and insulin. Leptin plays a significant role in the regulation of food intake and energy expenditure -elevated level in blood is one of the reasons of leptinresistance and obesity. In this study, the direct effect of resveratrol on leptin secretion from isolated adipocytes was investigated.

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“…Others compounds of similar activity include natural polyphenol (resveratrol) (Gnoni and Paglialonga, 2009) or macrocyclic polyketide (soraphen), which interacts with biotin carboxylase domain of ACCase and interferes with ACCase phosphorylation (Cho et al, 2010;Jump et al, 2011). Progress in the improvement of the properties of inhibitors depends on the assays for screening, validation and characterization of those compounds.…”

Section: Human Accase As Target In Diseases Treatmentmentioning

confidence: 99%

OPINIONS Acetyl-coenzyme A carboxylase – an attractive enzyme for biotechnology

Podkowiński¹,

Tworak²

2011

bta

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Acetyl-CoA carboxylase catalyzes the carboxylation of acetyl-CoA to malonyl-CoA. This reaction constitutes the first committed step of fatty acid synthesis in most organisms, while its product also serves as a universal precursor for various other high-value compounds. The important regulatory and rate-limiting role of acetyl-CoA carboxylase makes this enzyme a powerful tool in a variety of biotechnological and medical projects. This review presents the current knowledge on structural and functional features of the enzyme and focuses on its divergent applications. Different metabolic engineering attempts that lead to the production of various compounds, such as fatty acids, polyketides or flavonoids, are presented and their advantages and limitations discussed. The importance of studies on acetyl-CoA carboxylase activity for design and development of new herbicides and antibiotics as well as for medical intervention is also highlighted. Acetyl-coenzyme A carboxylase -enzyme architecture, biochemistry and its role in cell physiologyA variety of biotechnological projects targeted to modulate acetyl-coenzyme A carboxylase activity in bacteria, plants and humans have been proposed and experimentally tested. Here, we would like to present a comprehensive review of these strategies together with a survey of the potential of acetyl-CoA carboxylase for biotechnology.Acetyl-coenzyme A carboxylase (ACC, E.C.6.4.1.2), recognized as an essential enzyme for all Eukaryotes and the majority of Bacteria, is responsible for carboxylation of acetyl-CoA that results in malonyl-coenzyme A formation (Fig. 1). Malonyl-CoA is a major building block for compounds such as fatty acids, polyketides and flavonoids -important components for cell growth, as well as for food, pharmaceuticals and energy production.The malonyl-CoA synthesis consists of two half-reactions (Nikolau et al., 2003). The first one, adenosine triphosphate-dependent carboxylation of biotin prosthetic group covalently bound to a module named biotin carboxyl carrier protein (BCCP), is catalyzed by ACCase segment of biotin carboxylase activity (BC) (Fig. 2). This reaction is immediately followed by the second half-re action: the transfer of a carboxyl group from carboxylated biotin to acetyl-CoA, resulting in malonyl-CoA formation. Carboxyl transferase (CT) is a module that catalyzes the second reaction and provides the required specificity in recognition of the carboxyl acceptor (acetyl-CoA). The ACCase model usually presents BCCP, a module with covalently attached biotin, as a beam responsible for biotin dislocation between two active centers -one with BT and the other with CT activity. The three (Fig. 3). The prokaryotic and eukaryotic types of ACCases are evolutionary related and the phylogeny of the modules provides some hints about their cenancestor, a split between Archaea and Bacteria, and arising of Eukaryota (Lombard and Moreira, 2011).Phylogeny is out of scope of this manuscript, but acetyl-coenzyme A carboxylases from various organisms representing v...

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Resveratrol inhibits fatty acid and triacylglycerol synthesis in rat hepatocytes

Abstract: Results here reported show that in isolated hepatocytes from normal rats a resveratrol-induced short-term inhibition of fatty acid and triacylglycerol synthesis occurs. This finding may represent a potential mechanism contributing to the reported hypolipidemic effect of resveratrol.

Cited by 61 publications

References 40 publications

Piceatannol, Natural Polyphenolic Stilbene, Inhibits Adipogenesis via Modulation of Mitotic Clonal Expansion and Insulin Receptor-dependent Insulin Signaling in Early Phase of Differentiation

Piceatannol, Natural Polyphenolic Stilbene, Inhibits Adipogenesis via Modulation of Mitotic Clonal Expansion and Insulin Receptor-dependent Insulin Signaling in Early Phase of Differentiation

The inhibitory effect of resveratrol on leptin secretion from rat adipocytes

OPINIONS Acetyl-coenzyme A carboxylase – an attractive enzyme for biotechnology

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