Resveratrol inhibits Hexokinases II mediated glycolysis in non-small cell lung cancer via targeting Akt signaling pathway

CD147‐mediated glucose metabolic regulation contributes to the predictive role of 18F‐FDG PET/CT imaging for EGFR‐TKI treatment sensitivity in NSCLC

“…Similarly, CD147 also positively correlated with 18 F‐FDG uptake in the stable H1975 cell lines with different levels of CD147 (Figure B). As previously reported, the Akt/mTOR signaling pathway contributes significantly to tumor glycolysis and tumor progression . Consistently, Akt/mTOR signaling pathway activation was positively correlated with the CD147 expression level in the HCC827 cell line in the present investigation ( P < 0.0001) (Figure C), indicating the potential role of the Akt/mTOR‐dependent promotion of glucose metabolism on CD147 in NSCLC.…”

“…As previously reported, the Akt/mTOR signaling pathway contributes significantly to tumor glycolysis and tumor progression. 33,34 Consistently, Akt/mTOR signaling pathway activation was positively correlated with the CD147 expression level in the HCC827 cell line in the present investigation (P < 0.0001) ( Figure 3C), indicating the potential role of the Akt/mTOR-dependent promotion of glucose metabolism on CD147 in NSCLC. As expected, the uptake of 18 F-FDG ( Figure 3E) in the CD147-overexpressing HCC827 cell line was significantly reduced after treatment with an mTOR inhibitor (rapamycin) or Akt inhibitor (LY294002) ( Figure 3D).…”

Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review

“…Resveratrol has exhibited protective impacts on various cancers, like colorectal cancer, lung cancer, breast cancer, prostate cancer, ovarian cancer, cervical cancer, liver cancer, and gastric cancer ( Table 2) [14,[67][68][69][70][71]. For instance, resveratrol was reported to inhibit the formation and growth of colorectal cancer by downregulating oncogenic KRAS expression [68].…”

“…For instance, resveratrol was reported to inhibit the formation and growth of colorectal cancer by downregulating oncogenic KRAS expression [68]. Resveratrol also prevented tumorigenesis and progression of non-small cell lung cancer (NSCLC) cells by interrupting glycolysis via inhibition of hexokinase II expression, which was mediated by downregulation of the epidermal growth factor receptor (EGFR)/Akt/ERK1/2 signaling pathway [69]. Moreover, resveratrol showed pro-apoptotic/anti-proliferative effects in LNCaP cells (human prostate adenocarcinoma cells) through inducing the expression of cyclooxygenase (COX)-2, promoting ERK1/2 activation, and facilitating p53-dependent anti-proliferation gene expression [14].…”

Resveratrol inhibits VEGF‐induced angiogenesis in human endothelial cells associated with suppression of aerobic glycolysis via modulation of PKM2 nuclear translocation

“…A major challenge to date that remains, however, is our limited understanding regarding the detailed molecular mechanisms by which RST may influence angiogenesis. Recently, several studies have shown that RST exhibits an inhibitory effect on cellular glucose metabolism of various cancer cell lines such as ovarian, liver, breast, lung and colorectal cancer cells . In the above studies, most of the described effects of RST on reduction of glycolysis, as evidenced by decreased glucose uptake and lactate production, were corroborated to be mediated by PI3K/Akt and mTOR signalling.…”