Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins

Belguendouz, Leila; Frémont, Lucie; Linard, Alain

doi:10.1016/s0006-2952(96)00820-9

Cited by 280 publications

(156 citation statements)

References 39 publications

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“…In the present study, the combination treatment of 5-FU and resveratrol was investigated in order to develop modalities to overcome drug resistance. Resveratrol, a natural polyphenol present in grapes and red wine, has been observed to suppress the proliferation and survival of cancer cells via several mechanisms, including the inhibition of angiogenesis, induction of apoptosis and cell cycle arrest (1,3,26).…”

Section: Discussionmentioning

confidence: 99%

“…Resveratrol, a natural polyphenol found in grapes and red wine, is known to have various effects on antioxidant activity (1) and can induce apoptosis and inhibit angiogenesis in various types of cancer (2,3). In previous studies, resveratrol has been observed to induce apoptosis in glioma cells (4) and to inhibit the expression of hypoxia-inducible factor 1α and vascular endothelial growth factor (VEGF) via multiple mechanisms, including inhibition of protein kinase B and mitogen-activated protein kinase (MAPK) in human ovarian cancer cell lines (5).…”

Section: Introductionmentioning

confidence: 99%

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Anti-angiogenic effects of resveratrol in combination with 5-fluorouracil on B16 murine melanoma cells

Lee

Koo

Park

et al. 2015

Molecular Medicine Reports

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Abstract. 5-Fluorouracil (5-FU) has been used as a chemotherapeutic drug for various types of cancer, although the development of resistance remains a major limitation for its use in clinical settings. In the present study, the anti-angiogenic effects of resveratrol and 5-FU either alone or in combination were examined in a B16 murine melanoma model. Co-treatment using resveratrol and 5-FU inhibited cell proliferation more efficiently compared with use of either drug alone and the antiproliferative effect coincided with changes in the expression levels of AMP-activated protein kinase (AMPK), cyclooxygenase-2, vasodilator-stimulated phosphoprotein (VASP) and vascular endothelial growth factor (VEGF). Furthermore, co-treatment with resveratrol and 5-FU reduced tumor growth compared with that in the control group and this growth-inhibitory effect was associated with changes in the expression levels of AMPK, VASP and VEGF. Immunohistochemical staining for angiogenesis demonstrated that co-treatment with resveratrol and 5-FU reduced the number of microvascular vessels compared with that in the control group. These results suggested that co-treatment with resveratrol and 5-FU suppressed cell growth and angiogenesis in B16 murine melanoma tumors.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-angiogenic effects of resveratrol in combination with 5-fluorouracil on B16 murine melanoma cells

Lee

Koo

Park

et al. 2015

Molecular Medicine Reports

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“…The experiments performed in many laboratories confirmed that this effect was evoked by resveratrol; however, its action was exhibited by different mechanisms, e.g. the compound regulated the nitric oxide synthase activity [5], preserved acetylcholine-dependent relaxation of isolated aortic rings [6] and prevented peroxidative degradation of low density lipoproteins (LDL) [7,8].…”

Section: Introductionmentioning

confidence: 93%

The inhibitory effect of resveratrol on leptin secretion from rat adipocytes

Szkudelska

Nogowski

Szkudelski

2009

Eur J Clin Investigation

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Background Resveratrol was found to alleviate consequences of some metabolic disturbances which may be due to inappropriate dietary habits. It decreases mortality, increases insulin sensitivity and improves motor functions; these effects are accompanied by reduced plasma leptin and insulin. Leptin plays a significant role in the regulation of food intake and energy expenditure -elevated level in blood is one of the reasons of leptinresistance and obesity. In this study, the direct effect of resveratrol on leptin secretion from isolated adipocytes was investigated.

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“…There is now considerable evidence that wine phenolics, particularly resveratrol, inhibit lowdensity lipoprotein oxidation [5,6] and reduce platelet aggregation [7], two major parameters implicated in atherothrombogenesis. This provides a possible explanation for the cardioprotective action of wine [8].…”

Section: Introductionmentioning

confidence: 99%

Study of phenolic compounds as natural antioxidants by a fluorescence method

López

Martínez

Valle

et al. 2003

Talanta

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Much work has been carried out in recent years on the beneficial effect of phenolic compounds as natural antioxidants which help to neutralize free radicals. In fact, researchers have focused their attention on the pathological role of free radicals in a variety of diseases, among which the most important are atherosclerosis and cancer. Thus, among the components of the so-called 'Mediterranean Diet', phenolic compounds have received increased attention as epidemiological studies have shown that consumption of foods and beverages rich in phenolics is correlated with reduced incidence of heart disease. In this study, four phenolic compounds: (1) 3,4,5-trihydroxybenzoic acid (gallic acid); (2) trans 3,4?,5-trihydroxystilbene (trans -resveratrol); (3) 3,3?,4?,5,7-pentahydroxyflavone (quercetin) and its glycoside (4) 3,3?,4?,5,7-pentahydroxyflavone Á/3-rutinoside (Rutin) have been subjected to antioxidant study by a fluorimetric assay. In this method, the rate of peroxidation induced by 2,2?-azobis (2-methylpropionamidine) dihydrochloride was monitored through the loss of fluorescence of the protein B-phycoerythrin (B-PE). Under appropriate conditions, the loss of B-PE fluorescence in the presence of reactive species is an index of oxidative damage of the protein. The inhibition of the action of reactive species by phenolic compounds, reflected in the protection against the loss of B-PE fluorescence in the fluorimetric assay, is a measure of its antioxidant capacity against the reactive species. The antioxidant effects of phenolic compounds have been investigated at different concentrations to relate activity to structural effects. It has been observed that the fluorescence decay due to peroxyl radical attack on B-PE decreases exponentially with time. As a reference compound for antioxidant capacity we used 6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylicacid (trolox), a water soluble tocopherol analogue. This compound reacts rapidly with peroxyl radicals, and, until the trolox is consumed, no loss in phycoerythrin fluorescence is observed. A linear correlation of the net protection value with the concentration of trolox was demonstrated. The phenolic compounds studied react with peroxyl radicals in a similar way to trolox. Quercetin and rutin were shown to have strong antioxidant activities. The results obtained here are in agreement with previous studies confirming that quercetin is the most antioxidant of the four polyphenolics. #

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Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins

Cited by 280 publications

References 39 publications

Anti-angiogenic effects of resveratrol in combination with 5-fluorouracil on B16 murine melanoma cells

Anti-angiogenic effects of resveratrol in combination with 5-fluorouracil on B16 murine melanoma cells

The inhibitory effect of resveratrol on leptin secretion from rat adipocytes

Study of phenolic compounds as natural antioxidants by a fluorescence method

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