Resveratrol inhibits urban particulate matter-induced COX-2/PGE2 release in human fibroblast-like synoviocytes via the inhibition of activation of NADPH oxidase/ROS/NF-κB

Tsai, Ming-Horng; Hsu, Lee Fen; Lee, Chiang Wen; Chiang, Yang‐Jen; Lee, Ming Hsueh; How, Jia Mei; Wu, Ching Mei; Huang, Chieh-Liang; Lee, I-Te

doi:10.1016/j.biocel.2017.05.015

Cited by 78 publications

(62 citation statements)

References 27 publications

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“…In vitro and in vivo studies have also demonstrated that NOX production and activation can be induced by CSI; findings that have also been shown in human studies . In this regard, a recent study demonstrated reduced activation of NADPH oxidase/ROS/NF‐κB pathways in human fibroblast‐like synoviocytes after resveratrol treatment, leading to the suppression of particulate matter air pollution‐induced COX‐2 expression and PGE2 release . Other studies have demonstrated the regulatory effect of resveratrol on the expression of NADPH oxidase .…”

Section: Discussionmentioning

confidence: 73%

“…54,55 In this regard, a recent study demonstrated reduced activation of NADPH oxidase/ROS/NF-κB pathways in human fibroblast-like synoviocytes after resveratrol treatment, leading to the suppression of particulate matter air pollution-induced COX-2 expression and PGE2 release. 56 Other studies have demonstrated the regulatory effect of resveratrol on the expression of NADPH oxidase. [57][58][59][60] Therefore, the observed reduction in NADPH oxidase levels demonstrated with resveratrol is consistent with reduced inflammatory bone loss caused by CIS.…”

Section: Discussionmentioning

confidence: 99%

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Resveratrol attenuates oxidative stress during experimental periodontitis in rats exposed to cigarette smoke inhalation

Corrêa¹,

Absy²,

Tenenbaum

et al. 2018

J of Periodontal Research

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Objectives This study aimed at investigating the effect of the systemic administration of resveratrol (RESV) on oxidative stress during experimental periodontitis in rats subjected to cigarette smoke inhalation. Material and Methods Experimental periodontitis (EP) was induced in 26 male Wistar rats by the insertion of a ligature around one of the first mandibular and maxillary molars. The animals were assigned randomly to the following groups: cigarette smoke inhalation (CSI; 3 times/d, 8 minutes/d) + resveratrol (10 mg/Kg), that is, SMK + RESV (n = 13) and cigarette smoke inhalation + placebo, that is, SMK + PLAC (n = 13). The substances were administered daily for 30 days (19 days prior and 11 days following EP induction), and then, the animals were euthanized. The maxillary specimens were processed for morphometric analysis of bone loss, and the tissue surrounding the first maxillary molars was collected for mRNA quantification of Sirtuin 1 (SIRT1) by real‐time PCR. The gingival tissues surrounding the mandibular first molars were collected for quantification of superoxide dismutase 1 (SOD1) and nicotinamide adenine dinucleotide phosphatase oxidase (NADPH) using an ELISA assay. Results Reduced bone loss was demonstrated in animals in the SMK + RESV group as compared to those in the SMK + PLAC (P < 0.05) group on the basis of morphometric analysis. Resveratrol promoted higher levels of SIRT and SOD (P < 0.05) as well as reduced levels of NADPH oxidase (P < 0.05) were found in tissues derived from animals in the SMK + RESV group when compared to those in the SMK + PLAC group. Conclusion Resveratrol is an efficient therapeutic agent that reduces exacerbation of bone loss found in animals with EP that were also exposed to smoke. The results suggest that its effects could be mediated, at least in part, by its antioxidant and anti‐inflammatory properties which attenuate the effects of oxidative stress on EP in the presence of cigarette smoke.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Resveratrol attenuates oxidative stress during experimental periodontitis in rats exposed to cigarette smoke inhalation

Corrêa¹,

Absy²,

Tenenbaum

et al. 2018

J of Periodontal Research

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“…Hydroxytyrosol acetate (HTy-Ac) is able to lower the activation of the Janus kinase-signal transducer and activator of transcription (JAK/STAT), mitogen-activated protein kinases (MAPKs), and nuclear transcription factor-kappa B (NF-κB) pathways and thus to downregulate the arthritic process in CIA mice [26,27]. In human fibroblast-like synoviocytes (FLSs) derived from arthritic tissues, resveratrol inhibits COX-2/PGE2 expression and reduces p65 phosphorylation [29]. Others signaling pathways may be involved in polyphenol benefits but they were not investigated here.…”

Section: Discussionmentioning

confidence: 99%

Chondroprotective Properties of Human-Enriched Serum Following Polyphenol Extract Absorption: Results from an Exploratory Clinical Trial

et al. 2019

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Polyphenols are widely acknowledged for their health benefits, especially for the prevention of inflammatory and age-related diseases. We previously demonstrated that hydroxytyrosol (HT) and procyanidins (PCy), alone or in combination, drive preventive anti-osteoathritic effects in vivo. However, the lack of sufficient clinical evidences on the relationship between dietary phytochemicals and osteoarthritis remains. In this light, we investigated in humans the potential osteoarticular benefit of a grapeseed and olive extract (OPCO) characterized for its hydroxytyrosol (HT) and procyanidins (PCy) content. We first validated, in vitro, the anti-inflammatory and chondroprotective properties of the extract on primary cultured human articular chondrocytes stimulated by interleukin-1 beta (IL-1 β). The sparing effect involved a molecular mechanism dependent on the nuclear transcription factor-kappa B (NF-κB) pathway. To confirm the clinical relevance of such a nutritional strategy, we designed an innovative clinical approach taking into account the metabolites that are formed during the digestion process and that appear in circulation after the ingestion of the OPCO extract. Blood samples from volunteers were collected following ingestion, absorption, and metabolization of the extract and then were processed and applied on human primary chondrocyte cultures. This original ex vivo methodology confirmed at a clinical level the chondroprotective properties previously observed in vitro and in vivo.

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“…RES has been experimented either in vitro or in vivo in rheumatoid arthritis. Using human fibroblast-like synoviocytes, RES mitigated NADPH oxidase activity and ROS generation, increased Sirt-1 mRNA and inhibited release of MMPs and receptor activator of NF-B ligand [241][242][243][244]. In rabbit arthritis, intra-articular injection of RES dramatically reduced cartilage destruction [245].…”

Section: Allergy and Autoimmune Diseasesmentioning

confidence: 99%

Recent Advances on the Anti-inflammatory and Anti-oxidant properties of Red Grape Polyphenols: In Vitro and in Vivo Studies

Magrone¹,

Magrone²,

Russo³

et al. 2019

Preprint

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In this review, special emphasis will be placed on red grape polyphenols for their anti-oxidant and anti-inflammatory activities. Therefore, their capacity to inhibit major pathways responsible for activation of oxidative systems and expression and release of pro-inflammatory cytokines and chemokines will be discussed. Furthermore, regulation of immune cells by polyphenols will be illustrated with special reference to the activation of T regulatory cells which support a tolerogenic pathway at intestinal level. Furthermore, the effects of red grape polyphenols will be analyzed in obesity, as a low grade systemic inflammation. Also, possible modifications of inflammatory bowel disease biomarkers and clinical course have been studied upon polyphenol administration, either in animal models or in clinical trials. Moreover, the ability of polyphenols to cross the blood-brain barrier has been exploited to investigate their neuroprotective properties. In cancer, polyphenols seem to exert several beneficial effects, even if conflicting data are reported about their influence on T regulatory cells. Finally, the effects of polyphenols have been evaluated in experimental models of allergy and autoimmune diseases. Conclusively, red grape polyphenols are endowed with a great anti-oxidant and anti-inflammatory potential but some issues, such as polyphenol bioavailability, activity of metabolites and interaction with microbiota, deserve deeper studies.

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Resveratrol inhibits urban particulate matter-induced COX-2/PGE2 release in human fibroblast-like synoviocytes via the inhibition of activation of NADPH oxidase/ROS/NF-κB

Cited by 78 publications

References 27 publications

Resveratrol attenuates oxidative stress during experimental periodontitis in rats exposed to cigarette smoke inhalation

Resveratrol attenuates oxidative stress during experimental periodontitis in rats exposed to cigarette smoke inhalation

Chondroprotective Properties of Human-Enriched Serum Following Polyphenol Extract Absorption: Results from an Exploratory Clinical Trial

Recent Advances on the Anti-inflammatory and Anti-oxidant properties of Red Grape Polyphenols: In Vitro and in Vivo Studies

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