Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults

Semba, Richard D.; Ferrucci, Luigi; Bartali, Benedetta; Urpí-Sardà, Mireia; Zamora-Ros, Raúl; Sun, Kai; Cherubini, Antonio; Bandinelli, Stefania; Andrés‐Lacueva, Cristina

doi:10.1001/jamainternmed.2014.1582

Cited by 153 publications

(139 citation statements)

References 38 publications

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“…The health benefits of resveratrol, however, appear to be dose dependent. A prospective cohort study on 1270 Tuscans over the age of 65 years found that dietary resveratrol levels were not associated with CVD, inflammatory markers, cancer or a lower all-cause mortality risk (35) . Conversely, studies prescribing Abbreviations: DM, diabetes mellitus; Res, resveratrol; SBP, systolic blood pressure; STZ, streptozotocin; STZ + Res, streptozotocin-induced diabetic rats treated with resveratrol.…”

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confidence: 99%

Resveratrol shows neuronal and vascular-protective effects in older, obese, streptozotocin-induced diabetic rats

et al. 2016

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Diabetes-induced CVD is the most significant complication of prolonged hyperglycaemia. The aim of this study was to determine whether resveratrol, a polyphenol antioxidant compound, when administered at a dose that can be reasonably obtained through supplementation could prevent the development of cardiovascular complications in older, obese, diabetic rats. Diabetes was induced in 6-month old, obese, male Wistar rats via a single intravenous dose of streptozotocin (65 mg/kg). Randomly selected animals were administered resveratrol (2 mg/kg) via oral gavage daily for 8 weeks. Body weights, blood glucose levels, food intake and water consumption were monitored, and assessments of vascular reactivity, tactile allodynia and left ventricular function were performed. Resveratrol therapy significantly improved tactile allodynia and vascular contractile functionality in diabetic rats (P < 0·05). There were no significant changes in standardised vasorelaxation responses, plasma glucose concentrations, water consumption, body weight, left ventricular hypertrophy, kidney hypertrophy, heart rate or left ventricular compliance with resveratrol administration. Resveratrol-mediated improvements in vascular and nerve function in old, obese, diabetic rats were associated with its reported antioxidant effects. Resveratrol did not improve cardiac function nor mitigate the classic clinical symptoms of diabetes mellitus (i.e. hyperglycaemia, polydypsia and a failure to thrive). This suggests that supplementation with resveratrol at a dose achievable with commercially available supplements would not produce significant cardioprotective effects in people with diabetes mellitus.

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confidence: 99%

Resveratrol shows neuronal and vascular-protective effects in older, obese, streptozotocin-induced diabetic rats

et al. 2016

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“…In a sub-sample (n = 1,000) of the PREDIMED (Prevención con Dieta Mediterránea) Study, high urinary levels of resveratrol metabolites were associated with a reduction in the prevalence of cardiovascular risk factors in high-risk patients [17]. Recently, in a cohort study (n = 789) with older, Italian, community-dwelling adults, total urinary resveratrol metabolite concentration was not associated with cardiovascular disease, cancer, or all-cause mortality [18]. Further cohort studies with a large sample size or clinical intervention trials are required to establish the role of the concentration of resveratrol in biological fluids, or its effect on secondary end points, on primary end points for disease.…”

Section: Resultsmentioning

confidence: 99%

Enrichment of Resveratrol in Wine through a New Vinification Procedure

Pastor¹,

Gargantini²,

Murgo³

et al. 2015

JLS

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Sulphur dioxide is used in the vinification process as an antimicrobial agent, but it is also considered as an important risk factor for liver diseases. Stilbenes have inhibitory effects on the growth of lactic acid bacteria strains isolated from wine. The authors investigated the viability of obtaining free-SO 2 resveratrol-enriched red wines. Substitution of sulfite (7 g/100kg) for resveratrol (150 mg/L and 300 mg/L) in the vinification process did not change the basic physical and chemical properties of wine or its sensorial profile. To the best of the authors' knowledge this is the first time that this type of vinification procedure is reported.

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“…42 In the SU.VI.MAX cohort, dietary resveratrol was not related to breast cancer risk in nearly 4,150 women with a median follow-up of 12.6 years. 50 However, in the Swiss…”

Section: Resveratrol and Health Effects: Epidemiological Evidencementioning

confidence: 98%

Resveratrol metabolite profiling in clinical nutrition research—from diet to uncovering disease risk biomarkers: epidemiological evidence

Rabassa

Zamora-Ros

Urpí-Sardà

et al. 2015

Annals of the New York Academy of Sciences

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Resveratrol is a bioactive plant compound that has drawn scientist and media attention due to its protective effects against a wide variety of illnesses, including cardiovascular diseases and cancer. In the last two decades, a plethora of preclinical studies have shown these beneficial effects, and some of them have been supported by clinical trials.However, there are few epidemiological studies assessing these relationships, showing mostly inconsistent results between them. This could be partially due to difficulty of accurately estimating dietary resveratrol exposure. The development of PhenolExplorer, a database containing resveratrol food composition data, will facilitate the estimation of resveratrol intake. Moreover, the discovery and validation of a nutritional biomarker of this exposure, urinary resveratrol metabolite profile, will allow a more accurate assessment of dietary resveratrol exposure. Few epidemiological studies have assessed the potential health effects of resveratrol. Resveratrol was not associated with total mortality, cancer or cardiovascular events; but it was associated with the improvement of serum glucose and triglyceride levels, and the decrease of heart-rate.Together, these findings suggest a potential cardioprotective effect of resveratrol in epidemiological studies, although the evidence is still scarce.

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Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults

Cited by 153 publications

References 38 publications

Resveratrol shows neuronal and vascular-protective effects in older, obese, streptozotocin-induced diabetic rats

Resveratrol shows neuronal and vascular-protective effects in older, obese, streptozotocin-induced diabetic rats

Enrichment of Resveratrol in Wine through a New Vinification Procedure

Resveratrol metabolite profiling in clinical nutrition research—from diet to uncovering disease risk biomarkers: epidemiological evidence

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