Resveratrol-loaded chitosan–pectin core–shell nanoparticles as novel drug delivery vehicle for sustained release and improved antioxidant activities

Abstract

Resveratrol, chemically known as 3,5,4'-trihydroxy-trans-stilbene, is a natural polyphenol with promising multi-targeted health benefits. The optimal therapeutic uses of resveratrol are limited due to its poor solubility, rapid metabolism and low bioavailability. To address the issues, we have encapsulated resveratrol inside the nanosized core made of chitosan and coated this core with pectin-shell in order to fabricate a drug delivery vehicle which can entrap resveratrol for a longer period of time. The core–shell nanoparticles fabricated in this way were characterized with the help of Fourier transform infrared spectrometer, field-emission scanning electron microscope, field-emission transmission electron microscopy/selected area electron diffraction, high-resolution transmission electron microscope, dynamic light scattering and zeta potential measurements. In vitro drug release study showed the ability of the core–shell nanoparticles to provide sustained release of resveratrol for almost 30 h. The release efficiency of the drug was found to be pH dependent, and a sequential control over drug release can be obtained by varying the shell thickness. The resveratrol encapsulated in a nanocarrier was found to have a better in vitro antioxidant activity than free resveratrol as determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method. This work finally offers a novel nano-based drug delivery system.

Colon Delivery of Nutraceutical Ingredients by Food-Grade Polymeric Systems: An Overview of Technological Characterization and Biological Evaluation

“…FE-TEM/SAED images were obtained to obtain information on the internal morphology and particle distribution, where FE-TEM analysis revealed the formation of monodisperse core-shell particles with a spherical core of about 13 nm and a shell with an average thickness of about 4 nm; finally, SAED imaging showed circles and bright spots that highlighted the crystalline behavior of the encapsulated RSV. HR-TEM analysis confirmed the crystalline nature and, in relation to the amount of used pectin, showed an increase in the thickness of the coating [81].…”

Enhancing the Bioavailability of Resveratrol: Combine It, Derivatize It, or Encapsulate It?

“…Several studies have shown that biopolymer nanoparticle-mediated delivery can be a useful approach for improving the bioavailability of RSV. For example, Sarma et al encapsulated RSV in chitosan–pectin core-shell NPs, which resulted in enhanced RSV bioavailability (almost 30 h) and better in vitro radical scavenging activity than that of free RSV [ 166 ]. Sanna et al developed chitosan-alginate-coated poly(D,L-lactide-co-glycolide) nanoparticles loaded with RSV that provided significant protection against light-induced degradation [ 167 ].…”

Polymeric Nanoparticles for Delivery of Natural Bioactive Agents: Recent Advances and Challenges

“…In addition, it showed enhanced in vivo absorption, prolonged duration of action, and increased relative bioavailability by 3.5-fold when compared to free drugs. Sarma and coworkers developed chitosan-pectin core-shell nanoparticles loaded with resveratrol to improve its antioxidant activity and obtain prolonged release [176]. Liu and coworkers developed α-lactalbumin and chitosan core-shell nanoparticles loaded with resveratrol [177].…”