Resveratrol-mediated cleavage of amyloid β1–42 peptide: potential relevance to Alzheimer's disease

Al-Edresi, Sarmad; Alsalahat, Izzeddin; Freeman, Sally; Aojula, Harmesh; Penny, Jeffrey

doi:10.1016/j.neurobiolaging.2020.04.012

Cited by 40 publications

(16 citation statements)

References 53 publications

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“…Several natural products have been reported to be able to target these two phenylalanine residues and interact with Aβ through hydrogen bonds or hydrophobic interactions to destroy the normal structure of Aβ fibrils and block its toxicity in AD. Examples of these natural products include the polyphenol stilbene compound resveratrol that can decrease the formation of Aβ plaques [ 133 ], the major compound from the Sappan wood brazilin that can prevent abnormal Aβ aggregation [ 134 ], the polyphenol compound curcumin that interacts with F19 and F20 in the hydrophobic core domain of Aβ and disrupts their β-sheet structure to alleviate their toxicity [ 135 ], a polyphenol compound tannic acid that can stack with the hydrophobic domain of Aβ to prevent their polymerization into fibrils [ 136 ], destabilize the conformation of Aβ fibrils and promote the depolymerization of Aβ [ 137 ], and a group of polycyclic polyphenols theaflavin that binds to the hydrophobic core domain and hydrophobic C-terminus of Aβ to prevent the formation of toxic Aβ aggregates and induce the remodeling of misfolded Aβ aggregates [ 138 ].…”

Section: Neuroprotective Mechanisms Of Natural Products For Admentioning

confidence: 99%

Neuroprotective Natural Products for Alzheimer’s Disease

Chen

Drew

Berney

et al. 2021

Cells

137

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Alzheimer’s disease (AD) is the number one neurovegetative disease, but its treatment options are relatively few and ineffective. In efforts to discover new strategies for AD therapy, natural products have aroused interest in the research community and in the pharmaceutical industry for their neuroprotective activity, targeting different pathological mechanisms associated with AD. A wide variety of natural products from different origins have been evaluated preclinically and clinically for their neuroprotective mechanisms in preventing and attenuating the multifactorial pathologies of AD. This review mainly focuses on the possible neuroprotective mechanisms from natural products that may be beneficial in AD treatment and the natural product mixtures or extracts from different sources that have demonstrated neuroprotective activity in preclinical and/or clinical studies. It is believed that natural product mixtures or extracts containing multiple bioactive compounds that can work additively or synergistically to exhibit multiple neuroprotective mechanisms might be an effective approach in AD drug discovery.

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Section: Neuroprotective Mechanisms Of Natural Products For Admentioning

confidence: 99%

Neuroprotective Natural Products for Alzheimer’s Disease

Chen

Drew

Berney

et al. 2021

Cells

137

View full text Add to dashboard Cite

show abstract

“…In addition, curcumin and its derivatives can pass the BBB and have neuroprotective effects against mitochondrial dysfunction, damage, and nitrosative stress [ 46 ]. Moreover, resveratrol significantly decreased the Aβ -42 peptide toxicity toward SH-SY5Y cells that resulted in the cleavage of Aβ 1-42 peptides into smaller fragments [ 110 ]. Metabolism of flavan-3-ols by GM result in various arylvaleric acid, and aryl-γ-valerolactone derivatives that can selectively detoxify Aβ oligomers and prevent AD symptoms in mice [ 111 ].…”

Section: Polyphenolsmentioning

confidence: 99%

The Potential Role of Polyphenols in Oxidative Stress and Inflammation Induced by Gut Microbiota in Alzheimer’s Disease

et al. 2021

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Gut microbiota (GM) play a role in the metabolic health, gut eubiosis, nutrition, and physiology of humans. They are also involved in the regulation of inflammation, oxidative stress, immune responses, central and peripheral neurotransmission. Aging and unhealthy dietary patterns, along with oxidative and inflammatory responses due to gut dysbiosis, can lead to the pathogenesis of neurodegenerative diseases, especially Alzheimer’s disease (AD). Although the exact mechanism between AD and GM dysbiosis is still unknown, recent studies claim that secretions from the gut can enhance hallmarks of AD by disturbing the intestinal permeability and blood–brain barrier via the microbiota–gut–brain axis. Dietary polyphenols are the secondary metabolites of plants that possess anti-oxidative and anti-inflammatory properties and can ameliorate gut dysbiosis by enhancing the abundance of beneficial bacteria. Thus, modulation of gut by polyphenols can prevent and treat AD and other neurodegenerative diseases. This review summarizes the role of oxidative stress, inflammation, and GM in AD. Further, it provides an overview on the ability of polyphenols to modulate gut dysbiosis, oxidative stress, and inflammation against AD.

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“…Resveratrol has been shown to exhibit anti-cancer, anti-inflammatory, anti-aging, cardioprotective and anti-oxidant properties. 93,94 Also, it has anti-amyloidogenic effects and could inhibit the formation and extension of neurotoxic Aβ fibrils. 95 A cell line study by Vingtdeux et al studied the potential effect of resveratrol in AD.…”

Section: Phytochemicalsmentioning

confidence: 99%

Bioactive Compounds and Traditional Herbal Medicine: Promising Approaches for the Treatment of Dementia

Alzobaidi¹,

Quasimi²,

Emad³

et al. 2021

DNND

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Dementia is a term that encompasses a group of clinical symptoms affecting memory, thinking and social abilities, characterized by progressive impairment of memory performance and cognitive functions. There are several factors involved in the pathogenesis and progression of dementia, such as old age, brain ischemia, toxin exposure, and oxidative stress. There are extensive similarities between dementia and Alzheimer's disease (AD) either in clinical manifestations or experimental animal models. AD is the most dominant form of dementia, characterized by the accumulation of beta-amyloid protein and cholinergic neurotransmission deficits in the brain. Currently available medications for the treatment of dementia, such as choline esterase inhibitors, N-methyl-D-aspartate (NMDA) antagonists (memantine), have short-term efficacy and only relieve symptoms rather than targeting the main underlying pathogenesis. Several animal studies and clinical trials are being conducted to provide a rational approach to these medicinal plants in the prevention or treatment of memory deficits. This review highlights the potential effects of medicinal plants and their derived lead molecules, and explains the related mechanisms and effects reviewed from published literature as major thrust aspects and hopeful strategies in the prevention or treatment of dementia.

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Resveratrol-mediated cleavage of amyloid β1–42 peptide: potential relevance to Alzheimer's disease

Cited by 40 publications

References 53 publications

Neuroprotective Natural Products for Alzheimer’s Disease

Neuroprotective Natural Products for Alzheimer’s Disease

The Potential Role of Polyphenols in Oxidative Stress and Inflammation Induced by Gut Microbiota in Alzheimer’s Disease

Bioactive Compounds and Traditional Herbal Medicine: Promising Approaches for the Treatment of Dementia

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