Resveratrol, Metabolic Syndrome, and Gut Microbiota

Chaplin, Alice; Carpéné, Christian; Mercader, Josep M.

doi:10.3390/nu10111651

Cited by 202 publications

(168 citation statements)

References 217 publications

(362 reference statements)

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“…Intestinal bacteria can break RE to benzoic, phenylacetic, and propionic acids, while, in the liver, it undergoes phase II metabolism producing glucuronidated, sulfated, and methylated products which are known to retain part of the biological activity of the compound of origin [7,68,69,71]. For instance, in the liver, RE is usually metabolized to piceatannol ( Figure 2), which can be released into the bloodstream and can further give rise to piceatannol glucuronides or piceatannol sulfates that can return to the gut [72]. Interestingly, RE can also cause an increase of its own metabolism by enhancing the activity of phase II hepatic detoxifying enzymes [73].…”

Section: Resveratrol Has Poor In Vivo Pharmacokineticsmentioning

confidence: 99%

Potential Adverse Effects of Resveratrol: A Literature Review

Shaito

Posadino

Younes

et al. 2020

IJMS

437

293

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Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol's health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound. Ever since, several pharmacological activities including antioxidant, anti-aging, anti-inflammatory, anti-cancerous, anti-diabetic, cardioprotective, and neuroprotective properties, were attributed to RE. However, results from the available human clinical trials were controversial concerning the protective effects of RE against diseases and their sequelae. The reason for these conflicting findings is varied but differences in the characteristics of the enrolled patients, RE doses used, and duration of RE supplementation were proposed, at least in part, as possible causes. In particular, the optimal RE dosage capable of maximizing its health benefits without raising toxicity issues remains an area of extensive research. In this context, while there is a consistent body of literature on the protective effects of RE against diseases, there are relatively few reports investigating its possible toxicity. Indeed, toxicity and adverse effects were reported following consumption of RE; therefore, extensive future studies on the long-term effects, as well as the in vivo adverse effects, of RE supplementation in humans are needed. Furthermore, data on the interactions of RE when combined with other therapies are still lacking, as well as results related to its absorption and bioavailability in the human body. In this review, we collect and summarize the available literature about RE toxicity and side effects.In this process, we analyze in vitro and in vivo studies that have addressed this stilbenoid. These studies suggest that RE still has an unexplored side. Finally, we discuss the new delivery methods that are being employed to overcome the low bioavailability of RE.

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Section: Resveratrol Has Poor In Vivo Pharmacokineticsmentioning

confidence: 99%

Potential Adverse Effects of Resveratrol: A Literature Review

Shaito

Posadino

Younes

et al. 2020

IJMS

437

293

View full text Add to dashboard Cite

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“…Among stilbenes, trans ‐resveratrol is the main compound studied due to its acknowledged health‐benefits. [ 4,86,87 ] Resveratrol O ‐glucosides such as trans ‐piceid ( trans ‐resveratrol‐3‐ O ‐β‐D‐glucopyranoside) are also hydrolyzed into the resveratrol aglycone by the gut microbiota (Table 1). [ 74 ] Conversely, resveratrol can be glycosylated in the gut to produce piceid again.…”

Section: The Two‐way Interaction Between Phenolics and Gut Microbiotamentioning

confidence: 99%

Where to Look into the Puzzle of Polyphenols and Health? The Postbiotics and Gut Microbiota Associated with Human Metabotypes

Cortés‐Martín

Selma

Tomás‐Barberán

et al. 2020

Molecular Nutrition Food Res

196

240

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The full consensus on the role of dietary polyphenols as human-healthpromoting compounds remains elusive. The two-way interaction between polyphenols and gut microbiota (GM) (i.e., modulation of GM by polyphenols and their catabolism by the GM) is determinant in polyphenols' effects. The identification of human metabotypes associated with a differential gut microbial metabolism of polyphenols has opened new research scenarios to explain the inter-individual variability upon polyphenols consumption. The metabotypes unequivocally identified so far are those involved in the metabolism of isoflavones (equol and(or) O-desmethylangolesin producers versus non-producers) and ellagic acid (urolithin metabotypes, including producers of only urolithin-A (UM-A), producers of urolithin-A, isourolithin-A, and urolithin-B (UM-B), and non-producers (UM-0)). In addition, the microbial metabolites (phenolic-derived postbiotics) such as equol, urolithins, valerolactones, enterolactone, and enterodiol, and 8-prenylnaringenin, among others, can exert differential health effects. The knowledge is updated and position is taken here on i) the two-way interaction between GM and polyphenols, ii) the evidence between phenolic-derived postbiotics and health, iii) the role of metabotypes as biomarkers of GM and the clustering of individuals depending on their metabotypes (metabotyping) to explain polyphenols' effects, and iv) the gut microbial metabolism of catecholamines to illustrate the intersection between personalized nutrition and precision medicine.A. Cortés-Martín, Dr.

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“…After oral administration, RES is absorbed [41] and accumulates in various organs, such as the stomach [42], intestines, or liver [28,30,[42][43][44], as sites of its extensive absorption and metabolism [45]. RES (and its metabolites) is able to accumulate in target cells or organs of various diseases [46] including cancer, such as breast cancer tissue [47,48] and colorectal [49,50] or leukemia cancer cells [51].…”

Section: Accumulation Of Resveratrol In Tissuesmentioning

confidence: 99%

The Plant-Derived Compound Resveratrol in Brain Cancer: A Review

et al. 2020

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Despite intensive research, malignant brain tumors are among the most difficult to treat due to high resistance to conventional therapeutic approaches. High-grade malignant gliomas, including glioblastoma and anaplastic astrocytoma, are among the most devastating and rapidly growing cancers. Despite the ability of standard treatment agents to achieve therapeutic concentrations in the brain, malignant gliomas are often resistant to alkylating agents. Resveratrol is a plant polyphenol occurring in nuts, berries, grapes, and red wine. Resveratrol crosses the blood‒brain barrier and may influence the central nervous system. Moreover, it influences the enzyme isocitrate dehydrogenase and, more importantly, the resistance to standard treatment via various mechanisms, such as O6-methylguanine methyltransferase. This review summarizes the anticancer effects of resveratrol in various types of brain cancer. Several in vitro and in vivo studies have presented promising results; however, further clinical research is necessary to prove the therapeutic efficacy of resveratrol in brain cancer treatment.

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Resveratrol, Metabolic Syndrome, and Gut Microbiota

Cited by 202 publications

References 217 publications

Potential Adverse Effects of Resveratrol: A Literature Review

Potential Adverse Effects of Resveratrol: A Literature Review

Where to Look into the Puzzle of Polyphenols and Health? The Postbiotics and Gut Microbiota Associated with Human Metabotypes

The Plant-Derived Compound Resveratrol in Brain Cancer: A Review

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