Resveratrol mitigates miR-212-3p mediated progression of diesel exhaust-induced pulmonary fibrosis by regulating SIRT1/FoxO3

Singh, Naresh; Nagar, Ekta; Gautam, A. S.; Kapoor, Himanshi; Arora, Naveen

doi:10.1016/j.scitotenv.2023.166063

Cited by 6 publications

(2 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Resveratrol has been found to have antioxidative, anti-inflammatory, and immunomodulatory properties in several in vitro and in vivo investigations [ 3 ]. Promising results from many experimental studies indicate the positive impact of resveratrol supplementation in regulating gut health [ 4 ], cardiovascular diseases [ 5 ], inflammatory bowel disorders [ 6 ], cancer [ 7 ], liver diseases [ 8 ], diabetes [ 9 ], obesity [ 10 ], respiratory disorders [ 11 ], hypersensitivity [ 3 ], Alzheimer’s disease [ 3 ], and Parkinson’s disease [ 3 ]. These observations make resveratrol a remarkable compound with holistic effects at multiple levels in many diseases.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol as a Promising Nutraceutical: Implications in Gut Microbiota Modulation, Inflammatory Disorders, and Colorectal Cancer

Prakash,

Bose,

Sunilkumar

et al. 2024

IJMS

View full text Add to dashboard Cite

Natural products have been a long-standing source for exploring health-beneficial components from time immemorial. Modern science has had a renewed interest in natural-products-based drug discovery. The quest for new potential secondary metabolites or exploring enhanced activities for existing molecules remains a pertinent topic for research. Resveratrol belongs to the stilbenoid polyphenols group that encompasses two phenol rings linked by ethylene bonds. Several plant species and foods, including grape skin and seeds, are the primary source of this compound. Resveratrol is known to possess potent anti-inflammatory, antiproliferative, and immunoregulatory properties. Among the notable bioactivities associated with resveratrol, its pivotal role in safeguarding the intestinal barrier is highlighted for its capacity to prevent intestinal inflammation and regulate the gut microbiome. A better understanding of how oxidative stress can be controlled using resveratrol and its capability to protect the intestinal barrier from a gut microbiome perspective can shed more light on associated physiological conditions. Additionally, resveratrol exhibits antitumor activity, proving its potential for cancer treatment and prevention. Moreover, cardioprotective, vasorelaxant, phytoestrogenic, and neuroprotective benefits have also been reported. The pharmaceutical industry continues to encounter difficulties administering resveratrol owing to its inadequate bioavailability and poor solubility, which must be addressed simultaneously. This report summarizes the currently available literature unveiling the pharmacological effects of resveratrol.

show abstract

Section: Introductionmentioning

confidence: 99%

Resveratrol as a Promising Nutraceutical: Implications in Gut Microbiota Modulation, Inflammatory Disorders, and Colorectal Cancer

Prakash,

Bose,

Sunilkumar

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Additionally, resveratrol ameliorates high glucose-induced endoplasmic reticulum stress, cellular apoptosis and hyperuricemia-induced renal injury ( Xiao et al, 2021 ; Zhang et al, 2020 ). Moreover, the anti-fibrotic effects of resveratrol have been well documented in several organ systems, including kidney ( Wang et al, 2022b ; Zhang et al, 2019 ), liver ( Anapali et al, 2022 ; Mostafa et al, 2023 ), lung ( Liu et al, 2023 ; Singh et al, 2023 ) and prostate ( Zeng et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol inhibits calcium oxalate crystal growth, reduces adhesion to renal cells and induces crystal internalization into the cells, but promotes crystal aggregation

Peerapen,

Putpeerawit,

Boonmark

et al. 2024

Current Research in Food Science

View full text Add to dashboard Cite

Iron-doped diesel exhaust early-in-life inhalation-induced cardiopulmonary toxicity in chicken embryo: Roles of ferroptosis and acyl hydrocarbon signaling

Wang,

Gong,

Yuan

et al. 2024

Environmental Pollution

View full text Add to dashboard Cite

Resveratrol mitigates miR-212-3p mediated progression of diesel exhaust-induced pulmonary fibrosis by regulating SIRT1/FoxO3

Cited by 6 publications

References 45 publications

Resveratrol as a Promising Nutraceutical: Implications in Gut Microbiota Modulation, Inflammatory Disorders, and Colorectal Cancer

Resveratrol as a Promising Nutraceutical: Implications in Gut Microbiota Modulation, Inflammatory Disorders, and Colorectal Cancer

Resveratrol inhibits calcium oxalate crystal growth, reduces adhesion to renal cells and induces crystal internalization into the cells, but promotes crystal aggregation

Iron-doped diesel exhaust early-in-life inhalation-induced cardiopulmonary toxicity in chicken embryo: Roles of ferroptosis and acyl hydrocarbon signaling

Contact Info

Product

Resources

About