Resveratrol Mitigates Rat Retinal Ischemic Injury: The Roles of Matrix Metalloproteinase-9, Inducible Nitric Oxide, and Heme Oxygenase-1

Liu, Xiaoqian; Wu, Bing-Jhih; Pan, Wynn H.T.; Zhang, Xiumei; Liu, Jorn‐Hon; Chen, Mimi; Chao, Fang-Ping; Chao, Hsiang Tai

doi:10.1089/jop.2012.0141

Cited by 56 publications

(45 citation statements)

References 32 publications

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“…A combination of single compounds or TCM combinations [24] might produce combined drug efects to the commercial agents due to their diferent treatment mechanisms with less complications. As described previously [9,[11][12][13][14][15]17], baicalein seems to have protective efect via antioxidation, antiapoptosis, HO-1upregulation and downregulation of HIF-1α, VEGF, and/or MMP-9. Furthermore, the underlying mechanism of the baicalein inhibition on retinal ischemia-induced upregulated MMP-9 level seems to be only ''in part'' associated with its anti-oxidative efect [13].…”

Section: Resveratrol Related To Mmp and Otherssupporting

confidence: 61%

“…In addition, Chi Ju Di Huang Wan (CJDHW), a "vision preserved" TCM combination, was demonstrated to protect against retinal ischemia through the atenuation of apoptosis, increase of antioxidative activity, downregulation of MMP-9, and inhibition of p38 mitogen-activated protein kinase (MAPK) [7]. Besides, eicient components of beverages, such as epigallocatechin-3-gallate [18] in green tea and resveratrol [15] in red wine, were also reported to possess protective efect on retinal ganglion cells injured after optic nerve axotomy and retinal ischemia, respectively. This review aimed at evaluating the efects of the following compounds or TCM combinations on retinal ischemia and their relations to MMPs.…”

Section: Introductionmentioning

confidence: 99%

“…However, the efects of resveratrol are not completely highlighted. Therefore, it has been investigated whether and how resveratrol protects against retinal I/R [15].…”

Section: Introductionmentioning

confidence: 99%

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Retinal Ischemia: MMP-9; Its Relation to Resveratrol, Baicalein, S-allyl L-cysteine and Chi Ju Di Huang Wan

Chao¹,

Chao²,

Chen³

2017

The Role of Matrix Metalloproteinase in Human Body Pathologies

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Ischemia has been reported to be related to matrix metalloproteinase-9 (MMP-9) level upregulation. Neovascular glaucoma (NVG) (in proliferative diabetic retinopathy and central/branch retinal vein occlusion) and age-related macular degeneration are known visionthreatening retinal ischemic disorders. In this review, an extensive discussion has been made into how MMP-9 is related to retinal ischemia and what the underlying mechanisms of various traditional Chinese medicine (TCM) compounds and combinations are. High intraocular pressure-induced retinal ischemic changes were characterized by decreased electroretinogram (ERG) b-wave amplitudes, a loss of choline acetyltransferase (ChAT) immunopositive amacrine neurons/processes, increased Müller's vimentin immunoreactivity, and profound retinal ganglion cell (RGC) death. It has also been observed hypoxia inducible factor-1α (HIF-1α), MMP-9 and vascular endothelium growth factor (VEGF) upregulation at the protein/mRNA levels. After ischemia, both the p38 mitogen-activated protein kinases (MAPKs)-stimulated MMP-9 upregulation and HIF-1α-triggered VEGF overexpression might result in neovascularization. Conclusively, baicalein seems to have neuroprotection via antioxidation, antiapoptosis, HO-1 upregulation and HIF-1α, VEGF, and/or MMP-9 downregulation. Furthermore, baicalein inhibition on retinal ischemia-induced MMP-9 upregulation seems to be "partly" associated with its antioxidation. Additionally, retinal ischemia, oxidative stress, and/or kainate excitotoxicity could be protected by resveratrol: "via MMP-9 and inducible nitric oxide synthetase (iNOS) downregulation, and heme oxygenase-1 (HO-1) upregulation," S-allyl L-cysteine (SAC): "through iNOS, HIF-1α, VEGF inhibition and/or MMP-9 downregulation, and antiapoptosis," Chi Ju Di Huang Wan: "by means of antiapoptosis, antioxidation, MMP-9 downregulation and p38 MAPK inhibition." Keywords: matrix metalloproteinase-9, retinal ischemia, traditional Chinese medicine, hypoxia inducible factor-1α, vascular endothelium growth factor, p38 mitogen-activated protein kinase, baicalein, resveratrol, inducible nitric oxide synthetase, heme oxygenase-1, S-allyl L-cysteine, Chi-Ju-Di-Huang-Wan

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Section: Resveratrol Related To Mmp and Otherssupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

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Retinal Ischemia: MMP-9; Its Relation to Resveratrol, Baicalein, S-allyl L-cysteine and Chi Ju Di Huang Wan

Chao¹,

Chao²,

Chen³

2017

The Role of Matrix Metalloproteinase in Human Body Pathologies

Self Cite

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“…In this regard, Chen and colleagues evaluated RSV‐induced mitochondrial biogenesis in retinal ganglion cell line RGC‐5. In this study, the authors have shown evidence about the role of RSV to attenuate serum deprivation‐induced elicited RGC‐5 cell death through the SIRT‐1‐dependent PGC‐1α subcellular translocation; therefore, they suggested promoting mitochondrial biogenesis in order to mitigate glaucomatous retinopathy (Liu et al., 2013). …”

Section: Resveratrol and Diseasesmentioning

confidence: 99%

Resveratrol: A miraculous natural compound for diseases treatment

Koushki

Amiri-Dashatan

Ahmadi

et al. 2018

Food Science & Nutrition

210

109

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Resveratrol (3, 5, 4′‐trihydroxystilbene) is a nonflavonoid polyphenol that naturally occurs as phytoalexin. It is produced by plant sources such as grapes, apples, blueberries, plums, and peanut. This compound has critical roles in human health and is well known for its diverse biological activities such as antioxidant and anti‐inflammatory properties. Nowadays, due to rising incidence of different diseases such as cancer and diabetes, efforts to find novel and effective disease‐protective agents have led to the identification of plant‐derived compounds such as resveratrol. Furthermore, several in vitro and in vivo studies have revealed the effectiveness of resveratrol in various diseases such as diabetes mellitus, cardiovascular disease, metabolic syndrome, obesity, inflammatory, neurodegenerative, and age‐related diseases. This review presents an overview of currently available studies on preventive properties and essential molecular mechanisms involved in various diseases.

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“…49 Suppression of MMP-2 and MMP-9 was also demonstrated in rats with ethinylestradiol-induced intrahepatic cholestasis of pregnancy 50 and in the retina of rats with high intraocular pressure-induced retinal ischemia. 51 In contrast to its effects on MMPs in tumour cells or in response to inflammation and ischemia, other studies have shown that resveratrol increases MMP secretion. 52 In one of our recent studies, topical application of resveratrol in rats pretreated with dexamethasone resulted in increased MMP-2 levels in the aqueous humor of rat eyes.…”

Section: Introductionmentioning

confidence: 99%

Targeting extracellular matrix remodeling in disease: Could resveratrol be a potential candidate?

Agarwal

2016

Exp Biol Med (Maywood)

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Disturbances of extracellular matrix homeostasis are associated with a number of pathological conditions. The ability of extracellular matrix to provide contextual information and hence control the individual or collective cellular behavior is increasingly being recognized. Hence, newer therapeutic approaches targeting extracellular matrix remodeling are widely investigated. We reviewed the current literature showing the effects of resveratrol on various aspects of extracellular matrix remodeling. This review presents a summary of the effects of resveratrol on extracellular matrix deposition and breakdown. Mechanisms of action of resveratrol in extracellular matrix deposition involving growth factors and their signaling pathways are discussed. Involvement of phosphoinositol-3-kinase/Akt and mitogen-activated protein kinase pathways and role of transcription factors and sirtuins on the effects of resveratrol on extracellular matrix homeostasis are summarized. It is evident from the literature presented in this review that resveratrol has significant effects on both the synthesis and breakdown of extracellular matrix. The major molecular targets of the action of resveratrol are growth factors and their signaling pathways, phosphoinositol-3-kinase/Akt and mitogen-activated protein kinase pathways, transcription factors, and SIRT-1. The effects of resveratrol on extracellular matrix and the molecular targets appear to be related to experimental models, experimental environment as well as the doses.

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Resveratrol Mitigates Rat Retinal Ischemic Injury: The Roles of Matrix Metalloproteinase-9, Inducible Nitric Oxide, and Heme Oxygenase-1

Cited by 56 publications

References 32 publications

Retinal Ischemia: MMP-9; Its Relation to Resveratrol, Baicalein, S-allyl L-cysteine and Chi Ju Di Huang Wan

Retinal Ischemia: MMP-9; Its Relation to Resveratrol, Baicalein, S-allyl L-cysteine and Chi Ju Di Huang Wan

Resveratrol: A miraculous natural compound for diseases treatment

Targeting extracellular matrix remodeling in disease: Could resveratrol be a potential candidate?

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