Resveratrol modulates Toxoplasma gondii infection induced liver injury by intervening in the HMGB1/TLR4/NF-κB signaling pathway

Lu, Jing-Mei; Jin, Guang-Nan; Lu, Yu-Nan; Zhao, Xudong; Lan, Hui-Wen; Mu, Shuai-Ru; Shen, Xinyu; Xu, G.; Jin, Changchun; Ma, Juan; Jin, Xuejun; Xu, Xiang; Li, Piao

doi:10.1016/j.ejphar.2021.174497

Cited by 23 publications

(8 citation statements)

References 55 publications

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“…Another probable function of resveratrol is blocking the HMGB1 by stimulating Nrf2, which could prohibit the production of ROS as well (Dong et al, 2015). Therefore, due to the contribution of HMGB1 in the dysfunction of mitochondria, resulting in the overproduction of ROS, resveratrol mitigates inflammation and stress oxidative by attenuating the expression of the HMGB1 during sepsis (Lu et al, 2021; Yang et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, sepsis could cause edema in the liver via damaging sodium pump function, which leads to sodium hold and hepatocyte apoptosis (Lelubre & Vincent, 2018). Resveratrol could ameliorate liver damage by inhibiting the translocation of HMGB1 from the nucleus to the cytoplasm of hepatocytes in septic patients, which, at least particularly, is mediated by SIRT1 (Lu et al, 2021; Yu et al, 2019). Furthermore, resveratrol exerts a protective effect against liver injury via suppressing the production of inflammatory cytokines namely TNF‐a and IL‐1B, which are accompanied by enhanced Cytokine‐induced neutrophil chemoattractant 1(CINC‐1), aryl hydrocarbon receptor expression, and aryl hydrocarbon receptor (AhR) nuclear translocator (Arnt) in the hepatocytes (Larrosa et al, 2011; Yu et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, due to the contribution of HMGB1 in the dysfunction of mitochondria, resulting in the overproduction of ROS, resveratrol mitigates inflammation and stress oxidative by attenuating the expression of the HMGB1 during sepsis (Lu et al, 2021;Yang et al, 2014).…”

Section: The Effects Of Resveratrol On Hmgb1mentioning

confidence: 99%

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A comprehensive insight into the molecular and cellular mechanisms of action of resveratrol on complications of sepsis a systematic review

Vajdi,

Sefidmooye Azar,

Mahmoodpoor

et al. 2023

Phytotherapy Research

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Sepsis and septic shock are still one of the most important medical challenges. Sepsis is an extreme and uncontrolled response of the innate immune system to invading pathogenesis. Resveratrol (3,5,4′‐trihydroxytrans‐stilbene), is a phenolic and non‐flavonoid compound naturally produced by some plants and fruits. The object of the current study is to systematically review the impacts of resveratrol and its mechanisms of function in the management of sepsis and its related complications. The guidelines of the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) statements were applied to perform the study (PROSPERO: CRD42021289357). We searched Embase, Web of Science, Google Scholar, Science Direct, PubMed, ProQuest, and Scopus databases up to January 2023 by using the relevant keywords. Study criteria were met by 72 out of 1415 articles screened. The results of this systematic review depict that resveratrol can reduces the complications of sepsis by affecting inflammatory pathways, oxidative stress, and modulating immune responses. Future human randomized clinical trials are necessary due to the promising therapeutic effects of resveratrol on sepsis complications and the lack of clinical trials in this regard.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A comprehensive insight into the molecular and cellular mechanisms of action of resveratrol on complications of sepsis a systematic review

Vajdi,

Sefidmooye Azar,

Mahmoodpoor

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

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“…The hepatoprotective activity of resveratrol on fibrosis can be explained by its ability to produce more IL-10 to promote the polarization of M(LPS) to M(IL-4)-like macrophages (Yu et al, 2019). Resveratrol can also protect the liver by interfering with the TLR4/NF-κB signaling pathway, inhibiting the production of tumor necrosis factor-α, inducible nitric oxide synthase, and HMGB1 (Lu et al, 2021;Stewart & Bewley, 1980). However, because the content of resveratrol in wine was low, the protection of wine on the liver in our study might not come from a monomeric substance.…”

Section: Discussionmentioning

confidence: 99%

Comparative study on the impact on mouse livers of different amounts of Chinese Baijiu, beer, and wine consumption

WANG

et al. 2022

Food Sci. Technol

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Due to chronic alcohol consumption, alcoholic liver disease (ALD) has become the second most common liver disease in the world. The study was to explore the effects of consuming different amounts of various alcoholic beverages on the liver of mice. Results showed wine contained far more polyphenols and organic acids than beer and Chinese Baijiu. When daily alcohol consumption was low (less than 100 mL/60 kg/day), the liver and serum indicators of mice treated with alcohol, beer, Chinese Baijiu, and wine were not significantly d ifferent fr om th ose in sa line gr oup. At 25 0 mL /60 kg /day, be er us ed si gnificantly damaged the liver and caused adverse changes in serum components, while wine did not cause changes in serum, indicating that it may cause less damage due to the existence of a large number of polyphenols. When the daily consumption exceeded 500 mL/60 kg/day, all four alcoholic beverages significantly increased serum markers of hepatic injury and decreased serum total antioxidant capacity and liver antioxidant enzyme levels, resulting in liver fat accumulation and serious pathological damage. At this level, beer used caused the most damage and wine the least. This study explores the appropriate drinking amount of different alcoholic beverages and provides a scientific reference for alcohol consumption.

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“…To begin with, ellagic acid has been found to reduce liver injury by upregulating the expression of Nrf-2 and downregulating the Bcl-2 and NF-κB signaling pathways in a rat model of CCl4-induced liver injury (Aslan et al, 2018) Toxoplasma gondii infection-induced liver injury HMGB1/TLR4/NF-κB(-) (Lu et al, 2021) CCl4-induced liver fibrosis NF-κB /AKT(-) (Zhang et al, 2016) CCl4-induced liver fibrosis PTEN/PI3K/AKT(+) (Zhu et al, 2020) Human HSC line (LX-2)cells and CCL4-induced liver fibrosis Hippo(+) (C. Li, Zhang, et al, 2021) Methionine/choline-deficient diet-induced NASH SIGIRR(+)/TLR(-)/NF-κB(-) (Che et al, 2020) HFD-induced NAFLD FAS/SREBP-1(-) (Hosseini et al, 2020) HepG2 and Hep3B PTEN/AKT(+) (Dai et al, 2020) H22-induced liver cancer CD8+CD122+Tregs(-) (Q. Zhang, Huang, et al, 2020) HepG2 and Huh7 PKA/AMPK/eEF2K(-) (Gao et al, 2021) Alcohol-aflatoxin B1-induced HCC NF-κB(-) (Rawat et al, 2020(Rawat et al, , 2021 Curcumin HSC MyD88(-) (He et al, 2017) CCL4-induce liver injury Nrf2/HO-1(+)/TGF-β1/Smad3(-) (Peng et al, 2018) Aflatoxin B(AFB1)-induced liver injury TLR4/RIPK(-) (S. Arsenic-induced hepaticinjury MAPK/NF-κB(-)/ Nrf2(+) (Xu et al, 2021) Overfeeding-induced NAFLD SIRT3(+) (Du et al, HepG2 and Huh-7 ET1/Wnt/β-catenin (J.…”

Section: Ellagic Acidmentioning

confidence: 99%

Human diet‐derived polyphenolic compounds and hepatic diseases: From therapeutic mechanisms to clinical utilization

Hu,

Zhang,

Wei

et al. 2023

Phytotherapy Research

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This review focuses on the potential ameliorative effects of polyphenolic compounds derived from human diet on hepatic diseases. It discusses the molecular mechanisms and recent advancements in clinical applications. Edible polyphenols have been found to play a therapeutic role, particularly in liver injury, liver fibrosis, NAFLD/NASH, and HCC. In the regulation of liver injury, polyphenols exhibit anti‐inflammatory and antioxidant effects, primarily targeting the TGF‐β, NF‐κB/TLR4, PI3K/AKT, and Nrf2/HO‐1 signaling pathways. In the regulation of liver fibrosis, polyphenolic compounds effectively reverse the fibrotic process by inhibiting the activation of hepatic stellate cells (HSC). Furthermore, polyphenolic compounds show efficacy against NAFLD/NASH by inhibiting lipid oxidation and accumulation, mediated through the AMPK, SIRT, and PPARγ pathways. Moreover, several polyphenolic compounds exhibit anti‐HCC activity by suppressing tumor cell proliferation and metastasis. This inhibition primarily involves blocking Akt and Wnt signaling, as well as inhibiting the epithelial‐mesenchymal transition (EMT). Additionally, clinical trials and nutritional evidence support the notion that certain polyphenols can improve liver disease and associated metabolic disorders. However, further fundamental research and clinical trials are warranted to validate the efficacy of dietary polyphenols.

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Resveratrol modulates Toxoplasma gondii infection induced liver injury by intervening in the HMGB1/TLR4/NF-κB signaling pathway

Cited by 23 publications

References 55 publications

A comprehensive insight into the molecular and cellular mechanisms of action of resveratrol on complications of sepsis a systematic review

A comprehensive insight into the molecular and cellular mechanisms of action of resveratrol on complications of sepsis a systematic review

Comparative study on the impact on mouse livers of different amounts of Chinese Baijiu, beer, and wine consumption

Human diet‐derived polyphenolic compounds and hepatic diseases: From therapeutic mechanisms to clinical utilization

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