Resveratrol, obesity and diabetes

Szkudelska, Katarzyna; Szkudelski, Tomasz

doi:10.1016/j.ejphar.2010.02.054

Cited by 298 publications

(195 citation statements)

References 69 publications

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“…Studies in mice and humans have shown that resveratrol can lower glucose levels and may be an effective intervention for the treatment of type 2 diabetes, a disease that is prevalent in both aging and obesity Milne et al 2007;Szkudelska and Szkudelski 2010). Resveratrol has also been shown to reduce oxidative damage in human cells and animal models (Szkudelska and Szkudelski 2010;Baur 2010;Frankel et al 2011). These studies along with the current findings support the hypothesis that resveratrol can promote health span partly through modulating oxidative stress pathways.…”

Section: Discussionsupporting

confidence: 81%

“…The gender-specific response to phytochemicals is intriguing but poorly understood. Some phytochemicals including resveratrol are also phytoestrogens (Szkudelska and Szkudelski 2010), which could potentially act synergistically with other hormones in female flies. This may result in a heightened responsiveness of females to supplementation of phytochemicals than males.…”

Section: Discussionmentioning

confidence: 99%

“…High fat and high protein diets are pronounced in modern societies producing increasing numbers of obese individuals including the aged (Szkudelska and Szkudelski 2010). These individuals are more susceptible to type 2 diabetes, cardiovascular disease, stroke, and a host of other age-related diseases.…”

Section: Discussionmentioning

confidence: 99%

“…These individuals are more susceptible to type 2 diabetes, cardiovascular disease, stroke, and a host of other age-related diseases. Studies in mice and humans have shown that resveratrol can lower glucose levels and may be an effective intervention for the treatment of type 2 diabetes, a disease that is prevalent in both aging and obesity Milne et al 2007;Szkudelska and Szkudelski 2010). Resveratrol has also been shown to reduce oxidative damage in human cells and animal models (Szkudelska and Szkudelski 2010;Baur 2010;Frankel et al 2011).…”

Section: Discussionmentioning

confidence: 99%

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The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster

Wang

Wheeler

Alberico

et al. 2011

AGE

101

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Resveratrol, a polyphenolic compound, has been shown to extend lifespan in different organisms. Emerging evidence suggests that the prolongevity effect of resveratrol depends on dietary composition. However, the mechanisms underlying the interaction of resveratrol and dietary nutrients in modulating lifespan remain elusive. Here, we investigated the effect of resveratrol on lifespan of Drosophila melanogaster fed diets differing in the concentrations of sugar, yeast extract, and palmitic acid representing carbohydrate, protein, and fat, respectively. Resveratrol at up to 200 μM in diets did not affect lifespan of wild-type female flies fed a standard, restricted or high sugar-low protein diet, but extended lifespan of females fed a low sugar-high protein diet. Resveratrol at 400 μM extended lifespan of females fed a high-fat diet. Lifespan extension by resveratrol was associated with downregulation of genes in aging-related pathways, including antioxidant peroxiredoxins, insulin-like peptides involved in insulin-like signaling and several downstream genes in Jun-kinase signaling involved in oxidative stress response. Furthermore, resveratrol increased lifespan of superoxide dismutase 1 (sod1) knockdown mutant females fed a standard or high-fat diet. No lifespan extension by resveratrol was observed in wild-type and sod1 knockdown males under the culture conditions in this study. Our results suggest that the gender-specific prolongevity effect of resveratrol is influenced by dietary composition and resveratrol promotes the survival of flies by modulating genetic pathways that can reduce cellular damage. This study reveals the context-dependent effect of resveratrol on lifespan and suggests the importance of dietary nutrients in implementation of effective aging interventions using dietary supplements.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster

Wang

Wheeler

Alberico

et al. 2011

AGE

101

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“…Most recently, resveratrol has been of interest because of its various favorable pharmacological effects of improving longevity (Howitz et al 2003, Picard et al 2004, Milne et al 2007. Accumulating evidence suggests that resveratrol has the potential to prevent obesity, diabetes, cardiovascular diseases, and a variety of human diseases (Szkudelska & Szkudelski 2010, Petrovski et al 2011. Several mechanisms, such as activation of Sirt1 or AMPK, have also been proposed to explain these effects of resveratrol (Turan et al 2012); however, the impact of resveratrol on 11b-HSD1 in adipose tissue has not been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol inhibits 11β-hydroxysteroid dehydrogenase type 1 activity in rat adipose microsomes

Tagawa¹,

Kubota²,

Kato³

et al. 2013

Journal of Endocrinology

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It has been suggested that resveratrol, a polyphenol in wine, can regulate adiposity because it decreases adipose deposition in mice and rats; however, the mechanism underlying this effect has not been fully clarified. In humans and rodents, 11b-hydroxysteroid dehydrogenase type 1 (11b-HSD1) is expressed in liver and adipose tissue. 11b-HSD1 converts inactive glucocorticoid into active glucocorticoid in adipocytes. Activated glucocorticoid plays an important role in the pathogenesis of central obesity. The objective of this study was to investigate the effects of resveratrol on 11b-HSD1 activity in rodent adipose tissue. 11b-HSD1 activity in microsomes from rat mesenteric adipose depots and 3T3-L1 adipocytes was determined in the presence of 11-dehydrocorticosterone with or without varying concentrations of resveratrol. Significant inhibition of 11b-HSD1 by resveratrol was observed in rat adipose microsomes and 3T3-L1 adipocytes within 10 min. Time-and dose-dependent effects were also observed. The 11b-HSD1 activity by resveratrol was also inhibited in rat epididymal adipose tissue, and this inhibition was not recovered by estrogen receptor blockers. The kinetic study revealed that resveratrol acted as a non-competitive inhibitor of 11b-HSD1. K i and IC 50 values of resveratrol were 39.6 and 35.2 mM respectively. Further, resveratrol did not affect the activities of 11b-HSD2 and hexose-6-phosphate dehydrogenase. These results suggest that the most likely mechanism of 11b-HSD1 inhibition by resveratrol is via interaction between resveratrol and 11b-HSD1 enzyme, rather than via a transcriptional pathway. We demonstrated that the antiobesity effects of resveratrol may partially be attributed to the inhibition of 11b-HSD1 activity in adipocytes.

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Overview of Functional Foods

Chhikara¹,

Panghal²

2022

Functional Foods

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Resveratrol, obesity and diabetes

Cited by 298 publications

References 69 publications

The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster

The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster

Resveratrol inhibits 11β-hydroxysteroid dehydrogenase type 1 activity in rat adipose microsomes

Overview of Functional Foods

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