Resveratrol Oligomers, Plant-Produced Natural Products With Anti-virulence and Plant Immune-Priming Roles

Abstract

Antibiotic resistance has become increasingly prevalent in the environment. Many alternative strategies have been proposed for the treatment and prevention of diverse diseases in agriculture. Among them, the modulation of bacterial virulence to bypass antibiotic resistance or boost plant innate immunity can be considered a promising drug target. Plant-produced natural products offer a broad spectrum of stereochemistry and a wide range of pharmacophores, providing a great diversity of biological activities. Here, we present a perspective on the putative role of plant-produced resveratrol oligomers as anti-virulence and plant-immune priming agents for efficient disease management. Resveratrol oligomers can decrease (1) bacterial motility directly and (2) indirectly by attenuating the bacterial type III secretion system (TT3S). They induce enhanced local immune responses mediated by two-layered plant innate immunity, demonstrating (3) a putative plant immune priming role.

Molecular Mechanism of Resveratrol and Its Therapeutic Potential on Female Infertility

“…It can be present in two isomeric forms; cist-and trans-, the latter being more prevalent [37]. In plants, it is produced as a protective component, where it has a role in defense against UV-related and other injuries, diseases, and pathogenic attacks [38,39].…”

Enhancing the Bioavailability of Resveratrol: Combine It, Derivatize It, or Encapsulate It?

“…2.2.6. Oligomerized RSV Derivatives RSV oligomerization involves the coupling of monomers via regioselective oxidative coupling (Figure 7) [146]. At least 92 RSV oligomers with biological activities that greatly depend on their molecular size have been reported, indicating that the addition of more RSV units increases the biological effectiveness and specificity of the oligomer.…”

Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022

“…110,111 Besides V. vinifera, resveratrol oligomers have been isolated from various other Vitis species and plant families such as Cyperaceae, Dipterocarpaceae, Fabiaceae, Gnetaceae, and Paeoniaceae. [112][113][114] Resveratrol oligomers have been found to interfere with the type III secretion system (T3SS) of various human and plant pathogens. 115,116 The T3SS system is a needlelike structure in Gram-negative bacteria that allows the bacteria to penetrate host cell membranes and transfer various substrates.…”