Resveratrol—Potential Antibacterial Agent against Foodborne Pathogens

Abstract

Bacterial foodborne pathogens are a significant health burden and the recent emergence of pathogenic resistant strains due to the excessive use of antibiotics makes it more difficult to effectively treat infections as a result of contaminated food. Awareness of this impending health crisis has spurred the search for alternative antimicrobials with natural plant antimicrobials being among the more promising candidates as these substances have good acceptability and likely low toxicity levels as they have long been used in traditional medicines. Resveratrol (3,5,4′-trihydroxystilbene) is a naturally occurring stilbenoid which has been gaining considerable attention in medical field due to its diverse biological activities - it has been reported to exhibit antioxidant, cardioprotective, anti-diabetic, anticancer, and antiaging properties. Given that resveratrol is phytoalexin, with increased synthesis in response to infection by phytopathogens, there has been interest in exploring its antimicrobial activity. This review aims to provide an overview of the published data on the antibacterial activity of resveratrol against foodborne pathogens, its mechanisms of action as well as its possible applications in food packing and processing; in addition we also summarize the current data on its potential synergism with known antibacterials and future research and applications.

Investigating the antioxidant potential of Streptomyces sp. MUSC 11 from mangrove soil in Malaysia

“…aspiculamyceticus [112] . The antileishmaniasis aminoglycoside (10) under the common name of paromomycin, was first reported from a Streptomyces species [113] and to date, appears on the WHO essential 20 th list of medicines [23] . Previous work by Ser et al detected compound (5) in Streptomyces extract of with potent antioxidant and anticancer activity [41] .…”

Genome sequence of Vibrio sp. SALL 6 isolated from shellfish

“…SALL 6 genome illustrates how extensive antibiotics have been utilized in agriculture and aquaculture settings. The efficacy of clinical antibiotics are declining, thus there is a need for non-antibiotic method such as bacteriophage application or natural plant antimicrobials to manage Vibrio infections in the aquaculture [36,37] .…”

The Bioprospecting of Anti-Vibrio Streptomyces species: Prevalence and Applications

“…Therefore, it necessitates the search for more effective alternatives to overcome this problem. In this regards, recent efforts have been evidenced in bioprospecting for natural products derived from plant [28][29][30][31][32] , animal [33] or microbial origins [34] with promising antimicrobial effects to facilitate future development of new strategies against the antibiotic resistant strains of Vibrio.…”