Resveratrol Pretreatment Decreases Ischemic Injury and Improves Neurological Function Via Sonic Hedgehog Signaling After Stroke in Rats

Yu, Pingping; Wang, Li; Tang, Fanren; Zeng, Li; Zhou, Luling; Song, Xiaosong; Jia, Wei; Chen, Jixiang; Yang, Qin

doi:10.1007/s12035-015-9639-7

Cited by 76 publications

(60 citation statements)

References 42 publications

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“…Inhibition of the Shh signaling pathway with the Smo inhibitor cyclopamine completely reversed the effects of resveratrol. These results suggest that resveratrol decreased cerebral ischemic injury and improved neurological function by upregulating Shh signaling pathway [76]. …”

Section: Sonic Hedgehog and Neurogenesis In Neurological Diseasesmentioning

confidence: 99%

Emerging Roles of Sonic Hedgehog in Adult Neurological Diseases: Neurogenesis and Beyond

Chen

Yang

Hwang

et al. 2018

IJMS

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Sonic hedgehog (Shh), a member of the hedgehog (Hh) family, was originally recognized as a morphogen possessing critical characters for neural development during embryogenesis. Recently, however, Shh has emerged as an important modulator in adult neural tissues through different mechanisms such as neurogenesis, anti-oxidation, anti-inflammation, and autophagy. Therefore, Shh may potentially have clinical application in neurodegenerative diseases and brain injuries. In this article, we present some examples, including ours, to show different aspects of Shh signaling and how Shh agonists or mimetics are used to alter the neuronal fates in various disease models, both in vitro and in vivo. Other potential mechanisms that are discussed include alteration of mitochondrial function and anti-aging effect; both are critical for age-related neurodegenerative diseases. A thorough understanding of the protective mechanisms elicited by Shh may provide a rationale to design innovative therapeutic regimens for various neurodegenerative diseases.

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Section: Sonic Hedgehog and Neurogenesis In Neurological Diseasesmentioning

confidence: 99%

Emerging Roles of Sonic Hedgehog in Adult Neurological Diseases: Neurogenesis and Beyond

Chen

Yang

Hwang

et al. 2018

IJMS

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“…Subsequently, this allows Gli-1/2 to enter the nucleus and initiating the expressions of target genes (Chari and McDonnell, 2007). A number of beneficial effects result from Shh signaling as demonstrated in various pathological states of brain and spinal cord pathology, including acute brain injury (Amankulor et al, 2009), Alzheimer's disease (Vazin et al, 2014), Parkinson's disease (Tsuboi and Shults, 2002), stroke (Yu et al, 2017), multiple sclerosis and demyelination (Franco et al, 2008), spinal cord injury (Bambakidis et al, 2010), and HIV-associated neurological disorders (Singh et al, 2016). Complementing these findings are results from reports indicating that activation of the Shh signaling pathway has beneficial effects against brain injury.…”

Section: Introductionmentioning

confidence: 99%

Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling

Liu

Bai

et al. 2020

Front. Pharmacol.

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Purmorphamine (PUR), an agonist of the Smoothened (Smo) receptor, has been shown to function as a neuroprotectant in acute experimental ischemic stroke. Its role in hypoxic-ischemic (HI) brain injury in neonatal mice remains unknown. Here we show that PUR attenuated acute brain injury, with a decrease in Bax/Bcl-2 ratio as well as inhibition of caspase-3 activation. These beneficial effects of PUR were associated with suppressing neuro-inflammation and oxidative stress. PUR exerted long-term protective effects upon tissue loss and improved neurobehavioral outcomes as determined at 14 and 28 days post-HI insult. Moreover, PUR increased synaptophysin (Syn) and postsynaptic density (PSD) protein 95 expression in HI-treated mice and attenuated synaptic loss. PUR upregulated the expression of Shh pathway mediators, while suppression of the Shh signaling pathway with cyclopamine (Cyc) reversed these beneficial effects of PUR on HI insult. Our study suggests a therapeutic potential for short-term PUR administration in HI-induced injury as a result of its capacity to exert multiple protective actions upon acute brain injury, long-term memory deficits, and impaired synapses. Moreover, we provide evidence indicating that one of the mechanisms underlying these beneficial effects of PUR involves activation of the Shh signaling pathway.

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“…The combination of mBMMSCs and Resveratrol provides a novel potential experimental protocol for alleviating EAE symptoms. Yu et al [144] investigated on whether Shh (Sonic hedgehog) pathway mediates Resveratrol to decrease cerebral ischemic injury and improve neurological function after stroke. The study suggests that pretreatment with Resveratrol significantly improved neurological function, decreased the volume of infarct, enhanced vitality, and reduced apoptosis of neurons in vivo and in vitro after stroke.…”

Section: Resveratrolmentioning

confidence: 99%

Role of medicinal plants in neurodegenerative diseases

et al. 2017

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Neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by progressive loss (and even death) of structure and function of neurons, and have created great burden to the individual and the society. The actual cause of various neurodegenerative diseases still remains a mystery in healthcare. Some of the commonly studied environmental factors causes for neurodegenerative diseases are protein degradation, oxidative stress, inflammation, environmental factor, mitochondrial defects, familial history, and abnormal protein accumulation in neuron. However ageing plays a very important role in neurodegenerative diseases. Medicinal plants and natural compounds, such as Withania somnifera (ashwagandha), Ginseng, curcumin, resveratrol, Baccopa monnieri, Ginkgo biloba, and Wolfberry have been applied to prevent or alleviate neurological diseases and relief of neurological symptoms reported in in vivo or in clinical trails. Natural compounds in nanosize range as a therapeutic agent possess the same activity as in native state. Nanodrug delivery helps to increase the bioavailability of the drug and thereby specifically target cells and tissues. Nanoparticles, polymeric nanomicelles, complex polymers nanocrystal, and nanofibers are used to carry the medicinal plants for drug delivery system in the treatment of neurodegenerative diseases. Especially, electrospinning and electrospraying as straightforward yet versatile techniques for the production of nanosized fibers and particles possess huge potential in encapsulation of natural compounds for the neurodegenerative diseases. This review is a study to understand the role of nanotechnology and natural compounds in neurodegenerative diseases associated with ageing.

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Resveratrol Pretreatment Decreases Ischemic Injury and Improves Neurological Function Via Sonic Hedgehog Signaling After Stroke in Rats

Cited by 76 publications

References 42 publications

Emerging Roles of Sonic Hedgehog in Adult Neurological Diseases: Neurogenesis and Beyond

Emerging Roles of Sonic Hedgehog in Adult Neurological Diseases: Neurogenesis and Beyond

Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling

Role of medicinal plants in neurodegenerative diseases

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