Resveratrol pretreatment mitigates LPS-induced acute lung injury by regulating conventional dendritic cells’ maturation and function

Guo, Bingnan; Peng, Yujia; Gu, Yuting; Zhong, Yi; Su, Chenglei; Liu, Lin; Chai, Dafei; Song, Tengfei; Zhao, Nan; Yan, Xianliang; Xu, Tao

doi:10.1515/biol-2021-0110

Cited by 6 publications

(8 citation statements)

References 52 publications

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“…Acute lung injury (ALI) is defined as an inflammation-mediated severe pulmonary disease that results in diffuse pulmonary interstitial and parenchymal edema, which may progress to potential acute respiratory distress syndrome (ARDS) [ 5 ]. Recently, a study showed that the incidence rate of ALI was 1~4% and the case fatality rate was 22~65% [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Melatonin Suppresses LPS-Induced Oxidative Stress in Dendritic Cells for Inflammatory Regulation via the Nrf2/HO-1 Axis

et al. 2022

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Melatonin, an indoleamine synthesized in the pineal gland of mammals, is a natural bioactive compound with powerful antioxidant and anti-inflammatory properties. Here, we evaluated whether melatonin has the capacity to moderate the oxidative stress of dendritic cells (DCs) for inflammatory control in an acute lung injury (ALI) model. Our findings showed that melatonin remarkably inhibited total nitric oxide synthase (T-NOS) activity, nitric oxide (NO) production, intracellular reactive oxygen species (ROS) levels, and lipid peroxidation (MDA detection) levels in both an LPS-induced murine ALI model and LPS-induced DCs. Meanwhile, the reduced glutathione (GSH) level and the GSH/GSSG ratio were recovered. In addition, antioxidant enzymes, such as glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD), were increased in these processes. Moreover, melatonin also inhibited the LPS-induced secretions of IL-1β, IL-6, and TGF-β in vivo and in vitro. Finally, we found that the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) axis was required in the inhibition of LPS-induced oxidative stress in DCs by melatonin. Altogether, these data indicate that melatonin strongly suppresses the LPS-induced oxidative stress in DCs, which is a promising DC-targeted strategy via inflammatory control for ALI treatment.

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Section: Introductionmentioning

confidence: 99%

Melatonin Suppresses LPS-Induced Oxidative Stress in Dendritic Cells for Inflammatory Regulation via the Nrf2/HO-1 Axis

et al. 2022

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“…Finally, we included 17 articles published from 2005 to 2021 ( Meng et al, 2005 ; Sha et al, 2009 ; Cao et al, 2011 ; Qi et al, 2012 ; Rieder et al, 2012 ; Zhang H.−X. et al, 2014 ; Zhang Z. et al, 2014 ; Liu et al, 2015 ; Jiang et al, 2016 ; Alghetaa et al, 2018 ; Wang et al, 2018 ; Yang et al, 2018 ; Hu et al, 2019 ; Tsai et al, 2019 ; Guo et al, 2021 ; Jiang et al, 2021 ; Wang et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

The therapeutic efficacy of resveratrol for acute lung injury—A meta−analysis of preclinical trials

Tang

et al. 2022

Front. Pharmacol.

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Background: Resveratrol (RES) has a protective effect on acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Our purpose was to conduct a meta−analysis to investigate the efficacy of RES for ALI/ARDS in animal models.Methods: PubMed, EMBASE and Web of Science were searched to screen relevant preclinical trials. The standardized mean difference (SMD) was used to compare the lung injury score, lung wet−dry weight ratio (W/D ratio), tumor necrosis factor−α (TNF−α), interleukin−1β (IL−1β), IL−6, IL−10, the number of neutrophils in bronchoalveolar lavage fluid (BALF) and the total protein in BALF between the treatment and control groups. SYRCLE’s risk of bias tool was used for quality assessment.Results: A total of 17 studies published from 2005 to 2021 were included in our study to calculate the SMD with corresponding confidence interval (CI). As compared with controls, RES significantly decreased the lung injury score (SMD −2.06; 95% CI −2.77, −1.35; p < 0.00001) and W/D ratio (SMD −1.92; 95% CI −2.62, −1.22; p < 0.00001). RES also reduced the number of neutrophils in BALF (SMD −3.03; 95% CI −3.83, −2.24; p < 0.00001) and the total protein in BALF (SMD −5.59; 95% CI −10.10, −1.08; p = 0.02). Furthermore, RES was found to downregulate proinflammatory mediators such as TNF−α (SMD −2.02; 95% CI −3.09, −0.95; p = 0.0002), IL−1β (SMD −2.51; 95% CI −4.00, −1.02; p = 0.001) and IL−6 (SMD −2.26; 95% CI −3.49, −1.04; p = 0.0003). But RES had little effect on the anti−inflammatory mediators such as IL−10 (SMD 2.80; 95% CI −0.04, 5.63; p = 0.05). Sensitivity analysis and stratified analysis were performed for the outcome indicators with heterogeneity.Conclusion: RES treatment is effective on reducing the severity of ALI. However, more animal studies and human trials are needed for further investigation. Our study may provide a reference for preclinical and clinical studies in the future to some extent.

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“…Dendritic cells (DCs) are part of the APCs with crucial roles in developing and modulation of both innate and adaptive immune responses (Kumar, 2018). Several studies elucidated that resveratrol could suppress the maturation of DCs and induce tolerogenic DCs with a reduction in the expression of surface molecules including CD80, CD40, and major histocompatibility complex class II (MHCII), MHCI, and CD86 (B. Guo et al, 2021; Jiang et al, 2019; Švajger et al, 2010). On the other hand, resveratrol induces the production of IL‐10 in DCs, thereby suppressing the proliferation and activation of T cells, which in turn attenuates the immune‐induced inflammation in sepsis (Jiang et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

A comprehensive insight into the molecular and cellular mechanisms of action of resveratrol on complications of sepsis a systematic review

Vajdi,

Sefidmooye Azar,

Mahmoodpoor

et al. 2023

Phytotherapy Research

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Sepsis and septic shock are still one of the most important medical challenges. Sepsis is an extreme and uncontrolled response of the innate immune system to invading pathogenesis. Resveratrol (3,5,4′‐trihydroxytrans‐stilbene), is a phenolic and non‐flavonoid compound naturally produced by some plants and fruits. The object of the current study is to systematically review the impacts of resveratrol and its mechanisms of function in the management of sepsis and its related complications. The guidelines of the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) statements were applied to perform the study (PROSPERO: CRD42021289357). We searched Embase, Web of Science, Google Scholar, Science Direct, PubMed, ProQuest, and Scopus databases up to January 2023 by using the relevant keywords. Study criteria were met by 72 out of 1415 articles screened. The results of this systematic review depict that resveratrol can reduces the complications of sepsis by affecting inflammatory pathways, oxidative stress, and modulating immune responses. Future human randomized clinical trials are necessary due to the promising therapeutic effects of resveratrol on sepsis complications and the lack of clinical trials in this regard.

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Resveratrol pretreatment mitigates LPS-induced acute lung injury by regulating conventional dendritic cells’ maturation and function

Cited by 6 publications

References 52 publications

Melatonin Suppresses LPS-Induced Oxidative Stress in Dendritic Cells for Inflammatory Regulation via the Nrf2/HO-1 Axis

Melatonin Suppresses LPS-Induced Oxidative Stress in Dendritic Cells for Inflammatory Regulation via the Nrf2/HO-1 Axis

The therapeutic efficacy of resveratrol for acute lung injury—A meta−analysis of preclinical trials

A comprehensive insight into the molecular and cellular mechanisms of action of resveratrol on complications of sepsis a systematic review

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