Resveratrol Pretreatment Protected against Cerebral Ischemia/Reperfusion Injury in Rats via Expansion of T Regulatory Cells

Yang, Hongna; Zhang, Anxin; Zhang, Yuqing; Ma, Siddiqui; Wang, Cuilan

doi:10.1016/j.jstrokecerebrovasdis.2016.04.014

Cited by 27 publications

(22 citation statements)

References 21 publications

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“…Pre-treatment of rats with resveratrol prior to MCAO injury was found to be neuroprotective and associated with lessened neurological deficits and infarct size. This effect was attributed to expansion of Treg in the spleens and ischaemic hemisphere, an increase in IL-10 and reduction in IL-6 and TNF-α in the plasma and ischemic hemisphere (136).…”

Section: Stroke and Cerebral Ischaemiamentioning

confidence: 99%

Protective and Regenerative Roles of T Cells in Central Nervous System Disorders

et al. 2019

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Pathogenic mechanisms of T cells in several central nervous system (CNS) disorders are well-established. However, more recent studies have uncovered compelling beneficial roles of T cells in neurological diseases, ranging from tissue protection to regeneration. These divergent functions arise due to the diversity of T cell subsets, particularly CD4+ T cells. Here, we review the beneficial impact of T cell subsets in a range of neuroinflammatory and neurodegenerative diseases including multiple sclerosis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, stroke, and CNS trauma. Both T cell-secreted mediators and direct cell contact-dependent mechanisms deliver neuroprotective, neuroregenerative and immunomodulatory signals in these settings. Understanding the molecular details of these beneficial T cell mechanisms will provide novel targets for therapeutic exploitation that can be applied to a range of neurological disorders.

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Section: Stroke and Cerebral Ischaemiamentioning

confidence: 99%

Protective and Regenerative Roles of T Cells in Central Nervous System Disorders

et al. 2019

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“…Increased levels of IL-10 have been shown to be protective against focal brain ischemia in animals, but clinical studies are lacking. [ 90 91 92 93 ] Increased expression of TGF-β and IGF-1 suppresses activity of Th1 and Th2 lymphocytes and enhances regulatory T-cells (Treg cells) and thereby can be neuroprotective after ischemia in animals. [ 68 72 94 95 96 97 ] However, their role in humans and especially after global I/R injury is yet to be determined.…”

Section: Brain Inflammation and Immunomodulatory Therapies After Cardmentioning

confidence: 99%

Hypothermia and brain inflammation after cardiac arrest

2018

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The cessation (ischemia) and restoration (reperfusion) of cerebral blood flow after cardiac arrest (CA) induce inflammatory processes that can result in additional brain injury. Therapeutic hypothermia (TH) has been proven as a brain protective strategy after CA. In this article, the underlying pathophysiology of ischemia-reperfusion brain injury with emphasis on the role of inflammatory mechanisms is reviewed. Potential targets for immunomodulatory treatments and relevant effects of TH are also discussed. Further studies are needed to delineate the complex pathophysiology and interactions among different components of immune response after CA and identify appropriate targets for clinical investigations.

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“…Resveratrol protects neurons against ischemic injury [45] and attenuates cognitive deficit in aged rats [46] and in scopolamine-induced memory impairment [47].…”

Section: Resveratrol and Its Glucosidesmentioning

confidence: 99%

BIOLOGICALLY ACTIVE COMPOUNDS OF KNOTWEED (Reynoutria spp.)

Patočka¹,

Navrátilová²,

Ovando³

2017

MMSL

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Knotweeds (Reynoutria Houtt.) are plants native to the Far East. Japanese knotweed was introduced from Japan to the unsuspecting West by the horticultural activities of Philippe von Siebold via his nursery at Leiden in the 1840s. By 1854, the plant had arrived at the Royal Botanic Gardens in Edinburgh. The plants were then sold by a large number of commercial nursery gardens around the country. Further vegetative spread followed naturally along watercourses. The knotweed is currently extremely persistant invasive plant. There is also an important source of many bioactive substances which could be used in biomedicine. The article discusses biomedically relevant constituents and its pharmacological and toxicological properties.

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Resveratrol Pretreatment Protected against Cerebral Ischemia/Reperfusion Injury in Rats via Expansion of T Regulatory Cells

Cited by 27 publications

References 21 publications

Protective and Regenerative Roles of T Cells in Central Nervous System Disorders

Protective and Regenerative Roles of T Cells in Central Nervous System Disorders

Hypothermia and brain inflammation after cardiac arrest

BIOLOGICALLY ACTIVE COMPOUNDS OF KNOTWEED (Reynoutria spp.)

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