Resveratrol prevents global cerebral ischemia-induced decrease in lipid content

Simão, Fabrício; Matté, Aline; Breier, Ana Carolina; Kreutz, Fernando; Trindade, Vera Maria Treis; Netto, Carlos Alexandre; Salbego, Christianne Gazzana

doi:10.1179/1743132812y.0000000116

Cited by 18 publications

(10 citation statements)

References 37 publications

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“…It possesses a wide range of biological effects including anti-apoptotic (9,10), anti-oxidative (11), anti-inflammatory (12) and anti-carcinogenic properties (13). Resveratrol has been reported to exhibit neuroprotective effects in the models of numerous diseases, such as cerebral ischemia (14,15), kainic acid-induced excitotoxicity (16), Huntington’s disease (17), Parkinson’s disease (18) and Alzheimer’s disease (19). However, data evaluating the effects of resveratrol in VaD are lacking.…”

Section: Introductionmentioning

confidence: 99%

Effects of resveratrol on apoptosis in a rat model of vascular dementia

Sun

Jia

et al. 2014

Experimental and Therapeutic Medicine

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Resveratrol is a natural polyphenol widely present in plants, particularly in the skin of red grapes and in wine. It possesses a wide range of biological effects and exhibits neuroprotective effects in numerous diseases. However, data evaluating the effects of resveratrol in vascular dementia (VaD) are lacking. In the present study, the permanent, bilateral common carotid artery occlusion rat model was used to study the effects of resveratrol on VaD. The Morris water maze was used to test the spatial learning and memory performance of the rats. The expression levels of Bax, Bcl-2, cleaved caspase-3 and cleaved poly(ADP-ribose) polymerase (PARP) in the hippocampus were measured. The results showed that resveratrol inhibited memory impairment in the VaD rat model, and attenuated the increases in the expression levels of Bax, cleaved caspase-3 and cleaved PARP and the reductions in the expression levels of Bcl-2 that were induced by VaD. These results provide a novel insight into the neuroprotective effects of resveratrol and its possible therapeutic role in VaD.

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Section: Introductionmentioning

confidence: 99%

Effects of resveratrol on apoptosis in a rat model of vascular dementia

Sun

Jia

et al. 2014

Experimental and Therapeutic Medicine

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“…The results concerning the use of RSV transported in RO represent a promising therapeutic alternative for the treatment of symptoms related to several diseases, including FM, as we have presented here. The therapeutic approach of RO-combined RSV is reinforced by data published by other groups, in which the effects of the RSV were improved by lipid core nanocapsules [ 30 , 54 ].…”

Section: Discussionmentioning

confidence: 97%

Coadministration of Resveratrol and Rice Oil Mitigates Nociception and Oxidative State in a Mouse Fibromyalgia-Like Model

Klein

Cintra

Binda

et al. 2016

Pain Research and Treatment

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The mechanism underlying pain symptoms in fibromyalgia (FM) is not fully understood. Oxidative stress has emerged as pathophysiological event occurring during the development of the disease. The present study aimed at investigating the efficacy of resveratrol associated with rice bran oil on fibromyalgia-like mice model. Subcutaneous injection of reserpine (0.25 mg/Kg) during 3 days produced fibromyalgia-like symptoms. Resveratrol and/or rice oil or pregabalin were administered through oral route in therapeutic (single dose) and preventive (four doses) schemes. In both schemes, treatment with resveratrol associated with rice bran oil and pregabalin significantly reduced mechanical allodynia and thermal hyperalgesia in animals. The preventive scheme displayed antidepressant effect which was demonstrated by the forced swimming test as well as reduced reactive species in the cerebrospinal fluid of reserpinized animals. Taken together, our data provide evidences that the intake of resveratrol associated with rice bran oil plays antinociceptive and antidepressant actions probably through reducing reactive species and suggests the involvement of oxidative stress in this model of FM as possible underlying mechanism of pathogenesis of the disease.

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“…Brain lipid metabolism was studied by bilateral common carotid artery ligation, a model for chronic cerebral hypoperfusion, which showed that dysbolism might be caused by compensatory secretory phospholipase A (2)‐mediated vasodilation . Another experiment used compound to prevent membrane lipid loss and suggested that lipid metabolism was important for the development of ischemic damage . A recent study suggested that cell cycle modulation resulted in neuroprotection in ischemia, which was mediated at least in part through inhibition of microglia proliferation and production of inflammatory cytokines .…”

Section: Discussionmentioning

confidence: 99%