Resveratrol prevents osteoporosis in ovariectomized rats by regulating microRNA-338-3p

Guo, Ding; Han, Yaxin; Liu, Cong; Liang, Dong; Tu, Guanjun

doi:10.3892/mmr.2015.3581

Cited by 44 publications

(53 citation statements)

References 19 publications

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“…Liu et al demonstrated that miR-338-3P suppressed the expression level of osterix, a transcription factor for osteoblast differentiation in BMSCs by targeting Runx2 and Fgfr2 [ 89 ]. Moreover, resveratrol could prevent the bone loss in ovariectomized rats by inhibiting miR-388-3P [ 90 ]. MiR-125b shows a negative effect on osteogenesis by targeting osterix.…”

Section: Regulatory Roles Of Micrornas In Bone Remodelingmentioning

confidence: 99%

The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis

Sun

Zhou

Chen

et al. 2016

BioMed Research International

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MicroRNAs are involved in many cellular and molecular activities and played important roles in many biological and pathological processes, such as tissue formation, cancer development, diabetes, neurodegenerative diseases, and cardiovascular diseases. Recently, it has been reported that microRNAs can modulate the differentiation and activities of osteoblasts and osteoclasts, the key cells that are involved in bone remodeling process. Meanwhile, the results from our and other research groups showed that the expression profiles of microRNAs in the serum and bone tissues are significantly different in postmenopausal women with or without fractures compared to the control. Therefore, it can be postulated that microRNAs might play important roles in bone remodeling and that they are very likely to be involved in the pathological process of postmenopausal osteoporosis. In this review, we will present the updated research on the regulatory roles of microRNAs in osteoblasts and osteoclasts and the expression profiles of microRNAs in osteoporosis and osteoporotic fracture patients. The perspective of serum microRNAs as novel biomarkers in bone loss disorders such as osteoporosis has also been discussed.

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Section: Regulatory Roles Of Micrornas In Bone Remodelingmentioning

confidence: 99%

The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis

Sun

Zhou

Chen

et al. 2016

BioMed Research International

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show abstract

“…In a recent study, resveratrol, which is a polyphenolic phytoestrogen with osteogenic and osteoinductive properties, exhibited the ability to prevent osteoporosis by suppressing miR-338-3p. Mechanistically, resveratrol treatment leads to suppressed miR-338-3p, followed by an increase in Runx2 expression [ 97 ].…”

Section: Epigenetic and Osteoporosismentioning

confidence: 99%

Epigenetic Regulation of Bone Remodeling and Its Impacts in Osteoporosis

Ghayor

Weber

2016

IJMS

102

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Epigenetics describes mechanisms which control gene expression and cellular processes without changing the DNA sequence. The main mechanisms in epigenetics are DNA methylation in CpG-rich promoters, histone modifications and non-coding RNAs (ncRNAs). DNA methylation modifies the function of the DNA and correlates with gene silencing. Histone modifications including acetylation/deacetylation and phosphorylation act in diverse biological processes such as transcriptional activation/inactivation and DNA repair. Non-coding RNAs play a large part in epigenetic regulation of gene expression in addition to their roles at the transcriptional and post-transcriptional level. Osteoporosis is the most common skeletal disorder, characterized by compromised bone strength and bone micro-architectural deterioration that predisposes the bones to an increased risk of fracture. It is most often caused by an increase in bone resorption that is not sufficiently compensated by a corresponding increase in bone formation. Nowadays it is well accepted that osteoporosis is a multifactorial disorder and there are genetic risk factors for osteoporosis and bone fractures. Here we review emerging evidence that epigenetics contributes to the machinery that can alter DNA structure, gene expression, and cellular differentiation during physiological and pathological bone remodeling.

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“…Presently, more than a hundred papers have confirmed that the effect of RSV in the prevention or treatment of various diseases, including prostate cancer [ 15 ], melanoma [ 16 ], breast cancer [ 17 ], lung tumors [ 18 ], white adipogenesis [ 19 ], liver steatosis [ 20 ], inflammation [ 21 , 22 ], neurodegenerative disorders [ 23 ], and osteoporosis [ 24 ], were mediated by miRNAs.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol-Induced Changes in MicroRNA Expression in Primary Human Fibroblasts Harboring Carnitine-Palmitoyl Transferase-2 Gene Mutation, Leading to Fatty Acid Oxidation Deficiency

et al. 2017

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Carnitine palmitoyltransferase-2 (CPT2) is a mitochondrial enzyme involved in long-chain fatty acid entry into mitochondria for their β-oxidation and energy production. Two phenotypes are associated with the extremely reduced CPT2 activity in genetically deficient patients: neonatal lethality or, in milder forms, myopathy. Resveratrol (RSV) is a phytophenol produced by grape plant in response to biotic or abiotic stresses that displays anti-oxidant properties, in particular through AP-1, NFκB, STAT-3, and COX pathways. Some beneficiary effects of RSV are due to its modulation of microRNA (miRNA) expression. RSV can enhance residual CPT2 activities in human fibroblasts derived from CPT2-deficient patients and restores normal fatty acid oxidation rates likely through stimulation of mitochondrial biogenesis. Here, we report changes in miRNA expression linked to CPT2-deficiency, and we identify miRNAs whose expression changed following RSV treatment of control or CPT2-deficient fibroblasts isolated from patients. Our findings suggest that RSV consumption might exert beneficiary effects in patients with CPT2-deficiency.

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Resveratrol prevents osteoporosis in ovariectomized rats by regulating microRNA-338-3p

Cited by 44 publications

References 19 publications

The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis

The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis

Epigenetic Regulation of Bone Remodeling and Its Impacts in Osteoporosis

Resveratrol-Induced Changes in MicroRNA Expression in Primary Human Fibroblasts Harboring Carnitine-Palmitoyl Transferase-2 Gene Mutation, Leading to Fatty Acid Oxidation Deficiency

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