Resveratrol prevents renal lipotoxicity in high-fat diet-treated mouse model through regulating PPAR-α pathway

Zhou, Yan; Lin, Suxian; Zhang, Lihe; Li, Yongji

doi:10.1007/s11010-015-2576-y

Cited by 34 publications

(26 citation statements)

References 36 publications

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“…Regarding renal function, a high fat diet, with or without grape juice, reduced urea levels. Changes in urea caused by the consumption of a high-fat diet were also observed in other studies, but in these studies the phenolic compounds were able to revert the damage caused by diet, restoring urea levels to normal [44,45]. Still regarding the renal profile, in our study there were no significant differences regarding creatinine levels.…”

Section: Discussionsupporting

confidence: 80%

Grape Juice Consumption with or without High Fat Diet during Pregnancy Reduced the Weight Gain and Improved Lipid Profile and Oxidative Stress Levels in Liver and Serum from Wistar Rats

et al. 2018

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The aim of this study was to evaluate the effects of high fat diet with or without grape juice during the pregnancy on gestational weight gain, biochemical parameters, and oxidative stress in plasma and liver from Wistar rats. Forty-nine rats were divided into four groups: control diet group (CD), high fat diet (HFD), grape juice and control diet (PGJCD), and grape juice and high fat diet (PGJHFD). During the treatment the weight gain of the rats was tracked. They had free access to their respective diets during 42 days of treatment. After offspring weaning, the mother rats were euthanized and blood and liver were collected. The high fat diet increased the total cholesterol and triglycerides serum levels as well as carbonyl levels in the liver, however this diet reduced the high-density lipoprotein (HDL) and urea levels in serum. Grape juice consumption reduced gestational body weight gain. In liver, the juice consumption increased sulfhydryl levels and reduced the superoxide dismutase (SOD) activity and TBARS level, in serum the consumption reduced aspartate aminotransferase (AST) and TBARS. We can conclude that the consumption of a diet rich in fat can promotes harmful effects on health during pregnancy, however the consumption of grape juice seems to be an important alternative to prevent oxidative damages and to promote the improvement of health.

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Section: Discussionsupporting

confidence: 80%

Grape Juice Consumption with or without High Fat Diet during Pregnancy Reduced the Weight Gain and Improved Lipid Profile and Oxidative Stress Levels in Liver and Serum from Wistar Rats

et al. 2018

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“…There is evidence that several functional foods or dietary bioactive compounds can attenuate lipotoxicity [52][53][54][55][56][57][58] . One extensively studied food is soybean, particularly soy protein.…”

Section: Nutrigenomicsmentioning

confidence: 99%

Nutrigenomics as a Tool in the Prevention of Lipotoxicity: The Case of Soy Protein

Torres

Torre-Villalvazo

Tovar

2019

RIC

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Obesity is associated with an increase of several metabolic disorders leading to the development of diseases such as type 2 diabetes and cardiovascular disease. This is due in part to the ectopic accumulation of triglycerides in organs that are non-adipose tissues, leading to lipotoxicity. Particularly, in the liver, the accumulation of lipids, mainly of triglycerides, leads to the formation of fatty liver. The accumulation of lipids in skeletal muscle and pancreas associates with insulin resistance and a decrease in insulin secretion, respectively. In addition, it has been suggested that dysbiosis of the gut microbiota can contribute to the process of lipid accumulation in non-adipose tissues, especially in the liver. The aim of the present review is to highlight the mechanisms associated with the development of lipotoxicity, and how with the advances in nutrigenomics, it is now possible to understand the molecular mechanisms by which some nutrients can attenuate the ectopic accumulation of triglycerides in non-adipose tissues. Particularly, we emphasize research conducted on the molecular mechanisms of action of soy protein and some of its isoflavones, and how these can reduce lipotoxicity by preventing the accumulation of lipids in the liver, skeletal muscle, and pancreas, as well as their role on the gut microbiota to attenuate the development of fatty liver. Thus, nutrigenom-ics is opening new dietary strategies based on several functional foods that can be used to ameliorate the pathologies associ

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“…By doing this, it prevents diseases commonly associated with mitochondrial dysfunction [87]. Additionally, resveratrol activates the AMP-activated protein kinase (AMPK) signaling pathway, which again is related to the activation of PGC-1α levels and the beneficial effects of resveratrol on mitochondrial function [88,89]. Furthermore, in a recent study, treatment with resveratrol showed promising results for the delay in PKD progression in Han:SRPD:PKD rats by inhibiting inflammation [90].…”

Section: Mitochondrial Dysfunction In Adpkdmentioning

confidence: 99%

Oxidative stress in autosomal dominant polycystic kidney disease: player and/or early predictor for disease progression?

et al. 2018

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Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations in PKD1 or PKD2 genes, is the most common hereditary renal disease. Renal manifestations of ADPKD are gradual cyst development and kidney enlargement ultimately leading to end-stage renal disease. ADPKD also causes extrarenal manifestations, including endothelial dysfunction and hypertension. Both of these complications are linked with reduced nitric oxide levels related to excessive oxidative stress (OS). OS, defined as disturbances in the prooxidant/antioxidant balance, is harmful to cells due to the excessive generation of highly reactive oxygen and nitrogen free radicals. Next to endothelial dysfunction and hypertension, there is cumulative evidence that OS occurs in the early stages of ADPKD. In the current review, we aim to summarize the cardiovascular complications and the relevance of OS in ADPKD and, more specifically, in the early stages of the disease. First, we will briefly introduce the link between ADPKD and the early cardiovascular complications including hypertension. Secondly, we will describe the potential role of OS in the early stages of ADPKD and its possible importance beyond the chronic kidney disease (CKD) effect. Finally, we will discuss some pharmacological agents capable of reducing reactive oxygen species and OS, which might represent potential treatment targets for ADPKD.

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Resveratrol prevents renal lipotoxicity in high-fat diet-treated mouse model through regulating PPAR-α pathway

Cited by 34 publications

References 36 publications

Grape Juice Consumption with or without High Fat Diet during Pregnancy Reduced the Weight Gain and Improved Lipid Profile and Oxidative Stress Levels in Liver and Serum from Wistar Rats

Grape Juice Consumption with or without High Fat Diet during Pregnancy Reduced the Weight Gain and Improved Lipid Profile and Oxidative Stress Levels in Liver and Serum from Wistar Rats

Nutrigenomics as a Tool in the Prevention of Lipotoxicity: The Case of Soy Protein

Oxidative stress in autosomal dominant polycystic kidney disease: player and/or early predictor for disease progression?

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