2012
DOI: 10.1507/endocrj.ej11-0194
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Resveratrol prevents streptozotocin-induced diabetes by inhibiting the apoptosis of pancreatic β-cell and the cleavage of poly (ADP-ribose) polymerase

Abstract: Streptozotocin (STZ) is used widely in experimental animal models of type 1 diabetes. STZ is a β-cell-specific toxin that induces irreversible and rapid apoptosis of pancreatic β-cells. Abstract. Resveratrol (3,5,4′-trihydroxystilbene; RSV) is one kind of polyphenolic phytoalexin that has many effects on metabolic diseases. This study aimed to evaluate the protective effect of RSV pretreatment on β-cell. Male Sprague Dawley rats weighing 200-230 g were divided into 4 groups: (1) RSV; (2) streptozotocin (STZ, 7… Show more

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Cited by 68 publications
(45 citation statements)
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“…Ku et al [42] reported that STZ injection induced diabetes in all rats not given RSV pretreatment, whereas none of the RSV-pretreated rats developed diabetes and explained such effect to the fact that pretreatment with RSV inhibited apoptosis and reduced the activation of caspase-3 and poly (ADP-ribose) polymerase.…”
Section: Tablementioning
confidence: 99%
“…Ku et al [42] reported that STZ injection induced diabetes in all rats not given RSV pretreatment, whereas none of the RSV-pretreated rats developed diabetes and explained such effect to the fact that pretreatment with RSV inhibited apoptosis and reduced the activation of caspase-3 and poly (ADP-ribose) polymerase.…”
Section: Tablementioning
confidence: 99%
“…First, this compound can activate AMPK and the downstream molecules, leading to diminution of insulin resistance in db/db mice [121, 122]. It also prevented cell death of pancreatic β cells induced by IAP in culture [123] and in STZ-treated mice [221]. In addition, resveratrol enhanced glucose-mediated insulin secretion in β cells via the activation of SIRT1 [124], one of the cellular targets of resveratrol [222, 223].…”
Section: Selected Medicinal Herbs and Compounds For T2dmentioning
confidence: 99%
“…In addition, RSV inhibits PARP enzyme cleavage, because of its caspase‐3 enzyme activity blockage and hence decreasing apoptosis of beta cells in STZ‐induced and STAZ‐NA‐induced degeneration of the cells (Figure 3). Protection of beta cells from apoptosis led to blood insulin‐level promotion and decreasing of blood glucose level in type 1 diabetes (Ku et al., 2012). Another main action of RSV compound can be explored in type 1 diabetic skeletal muscle.…”
Section: Resveratrol and Diseasesmentioning
confidence: 99%
“…In addition, RSV alleviated liver tissue abnormalities by hepatoprotective effects (Hamadi, Mansour, Hassan, Khalifi‐Touhami, & Badary, 2012). Overall, the anti‐diabetic effects of resveratrol well established in diabetic animals (Chang et al., 2011, 2014; Hamadi et al., 2012; Ku et al., 2012). Some of the possible mechanisms of resveratrol on type 1 diabetic animal models are shown in Figure 4.…”
Section: Resveratrol and Diseasesmentioning
confidence: 99%