Resveratrol Prevents the Development of Hypertension Programmed by Maternal Plus Post‐Weaning High‐Fructose Consumption through Modulation of Oxidative Stress, Nutrient‐Sensing Signals, and Gut Microbiota

Tain, You‐Lin; Lee, Wei‐Chia; Wu, Kay L H; Leu, Steve; Chan, Julie Y.H.

doi:10.1002/mnfr.201800066

Cited by 75 publications

(109 citation statements)

References 33 publications

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“…Akkermansia muciniphila is a mucin-degrading bacterium, considered by some authors as an important member of the gut microbiota for control of physiological and homeostatic functions during obesity and type 2 diabetes (Everard et al, 2013). Conversely, other studies showed that increased abundance of A. muciniphila is related to hypertension (Tain et al, 2018) and can impair intestinal barrier function after using mucin by these bacteria as a nutrient (Desai et al, 2016). Depletion of the mucus layer by enriched A. muciniphila was associated with higher susceptibility to a gastrointestinal pathogen.…”

Section: Discussionmentioning

confidence: 99%

Yeast fermentate prebiotic improves intestinal barrier integrity during heat stress by modulation of the gut microbiota in rats

et al. 2019

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Aims To evaluate efficacy of Saccharomyces cerevisiae fermentate prebiotic (EH) in protection of intestinal barrier integrity in rats during heat stress, to analyze the impact of heat stress and preventive treatment with EH on the structure of the gut microbiota. Methods and Results Two groups of rats were treated orally with EH or phosphate‐buffered saline for 14 days. On day 15, half of the rats in each group were exposed to heat stress conditions, while control animals were kept at room temperature. Histological and Western blot analyses of the intestine, culture‐based microbiological analysis and high‐throughput 16S rRNA sequencing for the gut microbiota were performed for each rat. Exposure of animals to heat stress conditions resulted in inhibition of tight junction (TJ) proteins expression, decrease of Paneth and goblet cells, decrease of beneficial and increase of pathogenic bacteria. Oral treatment of rats with EH before stress significantly prevents these adverse effects by elevation of the gut beneficial bacteria, particularly butyrate‐producing bacteria. Conclusions Essential effect of EH in protection of intestinal barrier integrity during heat stress is connected with beneficial modulation of the gut microbiota. Significance and Impact of the Study Our results will contribute to the development of new approaches to prevention of heat stress‐related complications.

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Section: Discussionmentioning

confidence: 99%

Yeast fermentate prebiotic improves intestinal barrier integrity during heat stress by modulation of the gut microbiota in rats

et al. 2019

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“…Fecal concentrations of acetate, butyrate, and propionate were measured using gas chromatography-mass spectrometry (GCMS-QP2010; Shimadzu, Kyoto, Japan) with flame ionization detector (FID) [26]. Analytical standard grades of acetate, propionate (both from Sigma-Aldrich, St. Louis, MO, USA), and butyrate (from Chem Service, West Chester, PA, USA) were used as internal standards.…”

Section: Gas Chromatography-flame Ionization Detector (Gc-fid)mentioning

confidence: 99%

“…Simple centrifugation processing was carried out to removes impurity, proteins, and other organic compounds. As described previously [26], all polymerase chain-reaction amplicons were mixed together for sequencing using an Illumina Miseq platform (Illumina, CA, USA) at the Genomic and Proteomic Core Laboratory, Kaohsiung Chang Gung Memorial Hospital (Kaohsiung, Taiwan). Amplicons were prepared according to the 16S Metagenomics Sequencing Library Preparation protocol (Illumina, CA, USA), and sequenced the variable V3-V4 regions of the 16S rRNA gene with the Illumina MiSeq platform (Illumina, CA, USA) in paired-end mode with 600-cycle sequencing reagent.…”

Section: Analysis Of Gut-microbiota Compositionmentioning

confidence: 99%

“…Western blot analysis was performed using the methods published previously [26]. Kidney cortex homogenate (200 µg) was loaded on a 10-15% polyacrylamide gel and separated by electrophoresis (200 V, 90 min).…”

Section: Western Blotmentioning

confidence: 99%

“…RNA was extracted from kidney cortex according to previously described methods [26]. RNA concentration and quality were checked by measuring optical density at 260 and 280 nm.…”

Section: Quantitative Real-time Polymerase Chain Reaction (Pcr)mentioning

confidence: 99%

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Hypertension Programmed by Perinatal High-Fat Diet: Effect of Maternal Gut Microbiota-Targeted Therapy

et al. 2019

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Hypertension can originate in early life caused by perinatal high-fat (HF) consumption. Gut microbiota and their metabolites short chain fatty acids (SCFAs), trimethylamine (TMA), and trimethylamine N-oxide (TMAO) are involved in the development of hypertension. Despite the beneficial effects of prebiotic/probiotic on human health, little is known whether maternal use of prebiotics/probiotics could protect offspring against the development of hypertension in adulthood. We investigated whether perinatal HF diet-induced programmed hypertension in adult offspring can be prevented by therapeutic uses of prebiotic inulin or probiotic Lactobacillus casei during gestation and lactation. Pregnant Sprague–Dawley rats received regular chow or HF diet (D12331, Research Diets), with 5% w/w long chain inulin (PRE), or 2 × 108 CFU/day Lactobacillus casei via oral gavage (PRO) during pregnancy and lactation. Male offspring (n = 8/group) were assigned to four groups: control, HF, PRE, and PRO. Rats were sacrificed at 16 weeks of age. Maternal prebiotic or probiotic therapy prevents elevated blood pressure (BP) programmed by perinatal HF consumption. Both prebiotic and probiotic therapies decreased the Firmicutes to Bacteroidetes ratio and renal mRNA expression of Ace, but increased abundance of genus Lactobacillus and Akkermansia. Additionally, prebiotic treatment prevents HF-induced elevation of BP is associated with reduced fecal propionate and acetate levels, while probiotic therapy restored several Lactobacillus species. Maternal probiotic or prebiotic therapy caused a reduction in plasma TMAO level and TMAO-to-TMA ratio. The beneficial effects of prebiotic or probiotic therapy on elevated BP programmed by perinatal HF diet are relevant to alterations of microbial populations, modulation of microbial-derived metabolites, and mediation of the renin-angiotensin system. Our results cast a new light on the use of maternal prebiotic/probiotic therapy to prevent hypertension programmed by perinatal HF consumption. The possibility of applying gut microbiota-targeted therapies as a reprogramming strategy for hypertension warrants further clinical translation.

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Regulatory effect of gut microbes on blood pressure

Yan

Sun

Zhou

et al. 2022

Anim Models and Exp Med

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Hypertension is an important global public health issue because of its high morbidity as well as the increased risk of other diseases. Recent studies have indicated that the development of hypertension is related to the dysbiosis of the gut microbiota in both animals and humans. In this review, we outline the interaction between gut microbiota and hypertension, including gut microbial changes in hypertension, the effect of microbial dysbiosis on blood pressure (BP), indicators of gut microbial dysbiosis in hypertension, and the microbial genera that affect BP at the taxonomic level. For example, increases in Lactobacillus, Roseburia, Coprococcus, Akkermansia, and Bifidobacterium are associated with reduced BP, while increases in Streptococcus, Blautia, and Prevotella are associated with elevated BP. Furthermore, we describe the potential mechanisms involved in the regulation between gut microbiota and hypertension. Finally, we summarize the commonly used treatments of hypertension that are based on gut microbes, including fecal microbiota transfer, probiotics and prebiotics, antibiotics, and dietary supplements. This review aims to find novel potential genera for improving hypertension and give a direction for future studies on gut microbiota in hypertension.

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Resveratrol Prevents the Development of Hypertension Programmed by Maternal Plus Post‐Weaning High‐Fructose Consumption through Modulation of Oxidative Stress, Nutrient‐Sensing Signals, and Gut Microbiota

Abstract: Targeting oxidative stress, nutrient-sensing signals, and gut microbiota by resveratrol might be a useful therapeutic strategy for the treatment of hypertension induced by excessive consumption of fructose in the adult rat offspring.

Cited by 75 publications

References 33 publications

Yeast fermentate prebiotic improves intestinal barrier integrity during heat stress by modulation of the gut microbiota in rats

Yeast fermentate prebiotic improves intestinal barrier integrity during heat stress by modulation of the gut microbiota in rats

Hypertension Programmed by Perinatal High-Fat Diet: Effect of Maternal Gut Microbiota-Targeted Therapy

Regulatory effect of gut microbes on blood pressure

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