Resveratrol-procyanidin blend: nutraceutical and antiaging efficacy evaluated in a placebo-controlled, double-blind study

Abstract

BackgroundSkin is constantly exposed to pro-oxidant environmental stress from several sources, including air pollutants, ultraviolet solar light, and chemical oxidants. Reactive oxygen species have been implicated in age-related skin disorders. Dietary bioactive antioxidant compounds, such as polyphenols, have beneficial effects on skin health. The advantage of a nutritional administration route is that blood delivers nutraceutical bioactive compounds continuously to all skin compartments, ie, the epidermis, dermis, and subcutaneous fat. The purpose of this study was to evaluate the topical and systemic effects of a dietary supplement containing resveratrol and procyanidin on age-related alterations to the skin, the skin antioxidant pool, and systemic oxidative stress levels.MethodsAn instrumental study was performed in 50 subjects (25 treated with supplements and 25 with placebo) to identify clinical features induced by chronoaging or photoaging. Product efficacy was evaluated after 60 days of treatment in terms of in vivo and in situ skin hydration, elasticity, and skin roughness levels, systemic oxidative stress levels by plasmatic derivatives of reactive oxygen metabolites and oxyadsorbent tests, and extent of the skin antioxidant pool.ResultsAfter 60 days of treatment, values for systemic oxidative stress, plasmatic antioxidant capacity, and skin antioxidant power had increased significantly. Additionally, skin moisturization and elasticity had improved, while skin roughness and depth of wrinkles had diminished. Intensity of age spots had significantly decreased, as evidenced by improvement in the individual typological angle.ConclusionNutraceutical and pharmacological intervention with a supplement characterized by a specific blend of resveratrol and procyanidin may be a promising strategy to support treatments for the reduction of skin wrinkling, as well as reducing systemic and skin oxidative stress.

Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence

“…[304] wanted to evaluate the topical and systemic effects of a grape supplement containing 8 mg resveratrol and procyanidins on age-related alterations to the skin, the skin antioxidant pool, and systemic oxidative stress levels. An instrumental study was performed in 50 subjects (placebo, n=25, and treatment, n=25) with clinical signs of skin aging (wrinkles, dull complexion, brown spots) to identify clinical features induced by chronoaging or photoaging.…”

A Perspective on Chemoprevention by Resveratrol in Head and Neck Squamous Cell Carcinoma

“…The investigators have reported that 4 weeks of resveratrol treatment, signifi cantly reduced triglyceride concentration and increased antioxidant status [ 4 ]. In another study resveratrol was evaluated against systemic oxidative stress, which revealed that it signifi cantly increases antioxidant properties [ 6 ]. Similarly, high level of resveratrol is shown to inhibit CYPs and interact with transporters which modify the CYPs-mediated metabolism [ 72 ].…”

Cosmeceuticals in Dermatology

“…Also, it is potentially useful for the management of diabetic ulcers, [ 84 ] to treat comedonal and in fl ammatory acne, to improve skin damaged by UV exposure and to promote healing in herpes simplex virus 1 infection in mice [85][86][87] . Recently, a double blind, placebo controlled study has shown that supplementation with a speci fi c grape extract containing 8 mg of resveratrol, is effective in reducing skin wrinkling and oxidative damage [ 88 ] .…”