Resveratrol promotes osteogenesis and alleviates osteoporosis by inhibiting p53

Abstract

Although osteoporosis is one of the most common chronic age-related diseases, there is currently no gold standard for treatment. Evidence suggests resveratrol, a natural polyphenolic compound, may be helpful in the treatment of osteoporosis and other diseases. However, the molecular mechanisms underlying the antiosteoporotic effects of resveratrol remain largely unknown. In the present study, KEGG pathway enrichment analysis of resveratrol-targeted genes identified 33 associated pathways, 12 of which were also involved in osteoporosis. In particular, the MDM2/p53 signaling pathway was identified as a potential key pathway among the shared pathways. In vitro experiments indicated that MDM2-mediated p53 degradation induced osteoblast differentiation, and resveratrol could partially reverse p53-dependent inhibition of osteogenic differentiation. These findings suggest resveratrol may alleviate osteoporosis at least in part by modulating the MDM2/p53 signaling pathway.

Influence of the Bioactive Diet Components on the Gene Expression Regulation

“…It is believed that LXRα acts as a cholesterol sensor, and after SREBP-1c induction, fatty acids are produced in order to esterify cholesterol, which in turn balances the cholesterol amount in the organism [210]. omega-3 fatty acids: DHA traumatic brain injury [272] vitamin A cholestasis [273] vitamin E chronic liver injury [274] Nrf2 inhibition apigenin lung cancer [275] luteolin colon cancer [276] keampferol non-small cell lung cancer [277] chrysin breast cancer, glioblastoma [278,279] gallic acid psoriasis-like skin disease, respiratory diseases [280,281] vitamin E asthma [282] zinc diabetic nephropathy [283] chrysin bladder cancer [305] gallic acid non-small cell lung cancer [306] omega-3 fatty acids: DHA renal cancer, multiple myeloma, pancreatic cancer [254,307,308] sulforaphane nasopharyngeal cancer, glioblastoma multiforme [160,309] activation of p53 curcumin gastric cancer, neuroblastoma, renal cell carcinoma [310][311][312] resveratrol prostate cancer, colon cancer, hepatocellular carcinoma, glioblastoma multiform, neuroblastoma, thyroid cancer [313][314][315][316][317][318][319] epigallocatechin-3-gallate liver cancer [320] vitamin D endometrial cancer [321] inhibition of p53 resveratrol osteoporosis, breast cancer [322,323] vitamin E breast cancer [324] Beside carbohydrates and fats, proteins are the third most important class of macromolecules that need to be received with diet. Although higher organisms are able to synthetize some amin...…”

Beraprost ameliorates postmenopausal osteoporosis by regulating Nedd4-induced Runx2 ubiquitination

“…To investigate the underlying mechanism, we performed RNA-Seq assay and identified p53 as the gene that changed most significantly following beraprost treatment. p53 plays a critical role in bone remodeling 23 , 35 . Mice with p53 gene knockout had higher bone mass than controls.…”

Baicalein ameliorates osteoporosis via AKT/FOXO1 signaling

“…Bioinformatics analysis has been widely used to unravel molecular and cellular mechanisms of several human diseases [ 9 – 11 ]. Therefore, in this study, we performed comprehensive bioinformatics analysis and in vitro experiments in the cellular model of glucocorticoid-induced osteoporosis (GIO) to identify molecular mechanisms underlying the therapeutic effects of BN in osteoporosis.…”