Resveratrol protects adult cardiomyocytes against oxidative stress mediated cell injury

Movahed, Ali; Yu, Liping; Thandapilly, Sijo Joseph; Louis, Xavier Lieben; Netticadan, Thomas

doi:10.1016/j.abb.2012.05.002

Cited by 78 publications

(48 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly, hepatic expression of SIRT1 and Mn-SOD genes was induced in wild-type rats by 0.02% resveratrol after 4 weeks of treatment (Nakata et al, 2012). The stimulation of Mn-SOD levels was also reported in cultured cardiomyocytes and in coronary artery endothelial cells (Movahed et al, 2012;Ungvari et al, 2009;Tanno et al, 2010). In human aortic smooth muscle cells, it increased the expression of heme oxygenase-1 (HO-1), which degrades pro-oxidant heme to biliverdin/bilirubin, iron, and carbon monoxide, consequently reducing ROS levels (Juan et al, 2005).…”

Section: Effects Of Resveratrol On Antioxidant Mechanisms Protecting mentioning

confidence: 74%

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases

Carrizzo

Forte

Damato

et al. 2013

Food and Chemical Toxicology

174

105

View full text Add to dashboard Cite

a b s t r a c tResveratrol-a natural polyphenolic compound-was first discovered in the 1940s. Although initially used for cancer therapy, it has shown beneficial effects against most cardiovascular and cerebrovascular diseases. A large part of these effects are related to its antioxidant properties. Here we review: (a) the sources, the metabolism, and the bioavailability of resveratrol; (b) the ability of resveratrol to modulate redox signalling and to interact with multiple molecular targets of diverse intracellular pathways; (c) its protective effects against oxidative damage in cardio-cerebro-vascular districts and metabolic disorders such as diabetes; and (d) the evidence for its efficacy and toxicity in humans. The overall aim of this review is to discuss the frontiers in the field of resveratrol's mechanisms, bioactivity, biology, and healthrelated use.

show abstract

Section: Effects Of Resveratrol On Antioxidant Mechanisms Protecting mentioning

confidence: 74%

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases

Carrizzo

Forte

Damato

et al. 2013

Food and Chemical Toxicology

174

105

View full text Add to dashboard Cite

show abstract

“…In correspondence, we have observed that treatment with RSVA405 and RSVA314 decreases the iNOS expression in the kidneys and concomitantly decreases peroxynitrite generation, as measured by nitrotyrosine levels (39), after I/R. It has been repeatedly demonstrated that many of the beneficial effects of resveratrol can be attributed to its antioxidant properties, either through direct scavenging properties or through the regulation of enzymes involved in redox balance (19, 49, 50). In a study by Bertilli et al pretreatment with resveratrol prior to bilateral renal ischemia in rats reduced oxidative stress and decreased renal-I/R induced mortality (16).…”

Section: Discussionmentioning

confidence: 99%

Novel resveratrol analogues attenuate renal ischemic injury in rats

Khader

Yang

Kuncewitch

et al. 2015

Journal of Surgical Research

View full text Add to dashboard Cite

Background Renal ischemia-reperfusion (I/R) is a severe clinical complication with no specific treatment. Resveratrol has been shown as a promising experimental agent in renal I/R due to its effect on cellular energy metabolism, oxidative stress, and inflammation. Recently, we identified two biologically active resveratrol analogues (RSVAs), RSVA405 and RSVA314. We hypothesized that both RSAVs would attenuate I/R-induced renal injury. Methods Adult male rats were subjected to renal I/R through bilateral renal pedicle clamping for 60 min, followed by reperfusion. RSVA405 (3 mg/kg BW), RSVA314 (3 mg/kg BW), or vehicle (10% DMSO and 33% Solutol in PBS) was administered by intraperitoneal injection 1 h prior to ischemia. Blood and renal tissues were collected 24 h after I/R for evaluation. Results Administration of RSVA405 and RSVA314 significantly reduced the serum levels of renal dysfunction and injury markers, including creatinine, blood urea nitrogen, aspartate aminotransferase, and lactate dehydrogenase, compared to vehicle. The protective effect of RSVA405 and RSVA314 was also reflected on histologic evaluation. Both RSVAs reduced the number of apoptotic cells by more than 60% as determined by TUNEL assay, compared to vehicle. The renal ATP levels of the vehicle group was decreased to 52.4% of control, while those of the RSVA405 and RSVA314 groups were restored to 72.3% and 79.6% of control, respectively. Both RSVAs significantly reduced the protein expression of inducible nitric oxide synthase and nitrotyrosine, and the mRNA levels of TNF-α, IL-6 and IL-1β. Conclusions RSVA405 and RSVA314 attenuate I/R-induced renal injury through the modulation of energy metabolism, oxidative stress, and inflammation.

show abstract

“…Resveratrol, also known as trisphenol stilbene, is a type of strong bio-polyphenolic compounds, and mainly produced from grapes (red wine), knotweed, peanuts, mulberry and other plants [2]. It has diverse physiological and pharmacological activities and exhibits anti-cancer, chemopreventive, antiviral, cardio-protective, anti-aging, anti-nociceptive, and life-prolonging effects [3][4][5]. Many studies have shown that Res has significant inhibitory effect on a variety of malignant cells, such as breast cancer, stomach cancer, colon cancer, prostate cancer, leukemia, ovarian cancer, and skin cancer.…”

Section: Introductionmentioning

confidence: 99%

Effect and Mechanism of Resveratrol on the Apoptosis of Lung Adenocarcinoma Cell Line A549

Wang

Zhao

2015

Cell Biochem Biophys

View full text Add to dashboard Cite

Lung adenocarcinoma is the most common subtype of non-small cell lung cancer and the leading cause of cancer death worldwide. In this study, we investigated the effect of resveratrol (Res) on lung adenocarcinoma A549 cells and its potential mechanism. We found after Res treatment, the interspace of A549 cells decreased and granular material increased in the cell nucleus. These changes were remarkably correlated with the increased concentration of Res. Res induces apoptosis in A549 cells and inhibits cell proliferation in a dose-dependent manner. We further showed that after Res treatment, expression of p53, Bax, and cleaved caspase-3 protein was dramatically up-regulated, while expression of Bcl-2 and the ratio of Bcl-2/Bax were down-regulated. Our study demonstrates that Res inhibits proliferation and induces apoptosis of A549 cells through regulation of p53, Bax, Bcl-2, and cleaved caspase-3 expression.

show abstract

Resveratrol protects adult cardiomyocytes against oxidative stress mediated cell injury

Cited by 78 publications

References 27 publications

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases

Novel resveratrol analogues attenuate renal ischemic injury in rats

Effect and Mechanism of Resveratrol on the Apoptosis of Lung Adenocarcinoma Cell Line A549

Contact Info

Product

Resources

About