Resveratrol protects against irradiation-induced hepatic and ileal damage via its anti-oxidative activity

Velioğlu-Öğünç, Ayliz; Şehirli, Özer; Toklu, Hale Z.; Özyurt, Hazan; Mayadağlı, Alpaslan; Ekşioğlu, Emel; Erzik, Can; Çetınel, Şule; Yeğen, Berrak Ç.; Şener, Göksel

doi:10.1080/10715760903171100

Cited by 39 publications

(25 citation statements)

References 46 publications

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“…It is worth noting that there is evidence that RV can act as an ROS scavenger in normal cells to protect against ionizing radiation-induced oxidative stress and tissue injury [52], suggesting that RV may have differential effects on ROS production in normal versus cancer cells. Given that aberrant redox systems are frequently observed in many tumor cells [48], [53], [54], it is possible that RV may selectively suppress the growth of tumor cells with little or no toxicity to normal cells due to their differential redox status.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Induces Premature Senescence in Lung Cancer Cells via ROS-Mediated DNA Damage

et al. 2013

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Resveratrol (RV) is a natural component of red wine and grapes that has been shown to be a potential chemopreventive and anticancer agent. However, the molecular mechanisms underlying RV's anticancer and chemopreventive effects are incompletely understood. Here we show that RV treatment inhibits the clonogenic growth of non-small cell lung cancer (NSCLC) cells in a dose-dependent manner. Interestingly, the tumor-suppressive effect of low dose RV was not associated with any significant changes in the expression of cleaved PARP and activated caspase-3, suggesting that low dose RV treatment may suppress tumor cell growth via an apoptosis-independent mechanism. Subsequent studies reveal that low dose RV treatment induces a significant increase in senescence-associated β–galactosidase (SA-β-gal) staining and elevated expression of p53 and p21 in NSCLC cells. Furthermore, we show that RV-induced suppression of lung cancer cell growth is associated with a decrease in the expression of EF1A. These results suggest that RV may exert its anticancer and chemopreventive effects through the induction of premature senescence. Mechanistically, RV-induced premature senescence correlates with increased DNA double strand breaks (DSBs) and reactive oxygen species (ROS) production in lung cancer cells. Inhibition of ROS production by N-acetylcysteine (NAC) attenuates RV-induced DNA DSBs and premature senescence. Furthermore, we show that RV treatment markedly induces NAPDH oxidase-5 (Nox5) expression in both A549 and H460 cells, suggesting that RV may increase ROS generation in lung cancer cells through upregulating Nox5 expression. Together, these findings demonstrate that low dose RV treatment inhibits lung cancer cell growth via a previously unappreciated mechanism, namely the induction of premature senescence through ROS-mediated DNA damage.

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Section: Discussionmentioning

confidence: 99%

Resveratrol Induces Premature Senescence in Lung Cancer Cells via ROS-Mediated DNA Damage

et al. 2013

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“…Though rhodanese is not induced by DADS, it has been reported that it is induced by resveratrol [24] and that its activity is promoted by α-lipoic acid (LA) [25]. Resveratrol mitigates radiation-induced damage [26] and has been demonstrated to accumulate in the liver and protect hepatocytes from oxidative stress [27]. It has been observed that LA has radioprotective abilities [28], and the effects of LA on anti-stress responses are considered to be due to its anti-oxidative potential [29].…”

Section: Rhodanese Inducers and Radioprotective Functionsmentioning

confidence: 99%

Roles of Sulfur Metabolism and Rhodanese in Detoxification and Anti-Oxidative Stress Functions in the Liver: Responses to Radiation Exposure

Nakajima¹

2015

Med Sci Monit

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Organisms must confront various environmental stresses. The liver is central to protecting against such stresses in mammals, and it has many detoxification and anti-oxidative stress functions. Radiation is a source of oxidative stress and is known to affect the liver and induce anti-oxidative responses. The detoxification enzyme rhodanese, which is also called thiosulfate sulfurtransferase (TST), has been demonstrated to be induced in the liver in response to radiation. Cyanide detoxification is a function of the liver, and rhodanese is a key enzyme involved in sulfur metabolism in that detoxification. Though the anti-oxidative stress system in which sulfur molecules such as thiol compounds are involved has attracted attention as a defense against radiation, detoxification enzymes may have other roles in this defense. Understanding how these functions are affected by alterations of sulfur metabolism (including thiol compounds) after irradiation would help uncover their roles in defense against cancer and other deleterious health effects, as well as environmental stress responses. This article reviews the roles of sulfur-related metabolism in oxidative stress regulation and detoxification for recovery from liver damage after radiation exposure, with particular attention to recent findings of sulfur-related enzymes such as rhodanese, which is unique in sulfur metabolism.

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“…For biological decontamination of the packed food supplies the impermeable containers are boiled for 15 min/washed with soap and water followed by immersing in disinfectant solutions such as chlorine, bleaching solution, 5 per cent sodium carbonate, HTH (calcium hypochlorite) solution, super tropical bleach (STB) solution, 2 per cent per acetic acid. and aeration of the containers 41 . For nuclear decontamination the supplies must be washed with soap water followed by rinsing or brushing and wiping the contamination from surface.…”

Section: Effect Of Cbrn Agents On the Quality Of Food And The Decontamentioning

confidence: 99%

Nutritional Intervention during Chemical, Biological, Radiological, Nuclear Environments A Dietary Perspective

et al. 2019

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The future war scenario is based on use and applications of various conventional and non-convectional agents which includes weaponised or non-weaponised chemical, biological, radiological, nuclear (CBRN), toxic industrial materials, direct energy devices/ weapons, and or high yield explosives. These include nerve agents, blood agents, vesicants or skin blistering agents, lung irritants, asphyxiants or choking agents. Biological weapons are basically disease causing microorganisms and other replicating entities including viruses, infectious nucleic acids and prions. These agents have ability to infect host and are highly virulent, pathogenic and dangerous in nature. The interface between ammunitions and above agents is soldier whose physical and mental health is affected as enough precautionary measures are not adopted. The reducing environment thus created has various agents which enter into exposed body and lead to mild to serious damage to various vital parts of the human body. As food is important component for survival and intrinsic to basic human nutrition and health, therefore, it is imperative to develop certain kind of a wholesome meal system which can be consumed by the soldiers tasked with combating CBRN situations during such operations. Such meals can be in the form of solid or liquid type and packaged in suitable delivery system, compatible and amenable with the CBRN suit. Food can be contaminated during CBRN conditions by coming in direct or indirect contact with CBRN agents. Therefore, the food materials to be used under such conditions need to be protected in suitable coverings as consumption of contaminated food can be lethal. Designer meal for CBRN environment is not only suitable for soldiers but also to all human interface dealing with similar scenario viz. the low intensity conflicts and surgical operations, nuclear submarines, cosmonauts, pilots, individuals handling radiation equipment and patient undergoing chemotherapy for cancer.

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Resveratrol protects against irradiation-induced hepatic and ileal damage via its anti-oxidative activity

Cited by 39 publications

References 46 publications

Resveratrol Induces Premature Senescence in Lung Cancer Cells via ROS-Mediated DNA Damage

Resveratrol Induces Premature Senescence in Lung Cancer Cells via ROS-Mediated DNA Damage

Roles of Sulfur Metabolism and Rhodanese in Detoxification and Anti-Oxidative Stress Functions in the Liver: Responses to Radiation Exposure

Nutritional Intervention during Chemical, Biological, Radiological, Nuclear Environments A Dietary Perspective

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