Resveratrol Protects Müller Cells Against Ferroptosis in the Early Stage of Diabetic Retinopathy by Regulating the Nrf2/GPx4/PTGS2 Pathway

Wang, Yi; Song, Si-Yuan; Song, Yi; Wang, Yuan; Wan, Zheng-Wei; Sun, Ping; Yu, Xue-Mei; Deng, Bo; Zeng, Kai-Hong

doi:10.1007/s12035-024-04496-8

Mol Neurobiol

2024

DOI: 10.1007/s12035-024-04496-8

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Resveratrol Protects Müller Cells Against Ferroptosis in the Early Stage of Diabetic Retinopathy by Regulating the Nrf2/GPx4/PTGS2 Pathway

Yi Wang,

Si-Yuan Song,

Yi Song

et al.

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2024

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The Altered Proteomic Landscape in Renal Tubular Epithelial Cells under High Oxalate Stimulation

Hong,

Qin

2024

Biology

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Our study aimed to apply a proteomic approach to investigate the molecular mechanisms underlying the effects of oxalate on rat renal tubular epithelial cells. NRK-52E cells were treated with or without oxalate and subjected to quantitative proteomics to identify key proteins and key pathological changes under high oxalate stimulation. A total of 268 differentially expressed proteins (DEPs) between oxalate-treated and control groups were identified, with 132 up-regulated and 136 down-regulated proteins. Functional enrichment analysis revealed that DEPs are associated with oxidative stress, apoptosis, ferroptosis, pro-inflammatory cytokines, vitamin D, and biomineralization. SPP1, MFGE8, ANKS1A, and NAP1L1 were up-regulated in the oxalate-treated cells and the hyperoxaluric stone-forming rats, while SUB1, RNPS1, and DGLUCY were down-regulated in both cases. This altered proteomic landscape sheds light on the pathological processes involved in oxalate-induced renal damage and identifies potential biomarkers and therapeutic targets to mitigate the effects of hyperoxaluria and reduce the risk of CaOx stone formation.

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The Altered Proteomic Landscape in Renal Tubular Epithelial Cells under High Oxalate Stimulation

Hong,

Qin

2024

Biology

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Resveratrol Protects Müller Cells Against Ferroptosis in the Early Stage of Diabetic Retinopathy by Regulating the Nrf2/GPx4/PTGS2 Pathway

Cited by 1 publication

References 51 publications

The Altered Proteomic Landscape in Renal Tubular Epithelial Cells under High Oxalate Stimulation

The Altered Proteomic Landscape in Renal Tubular Epithelial Cells under High Oxalate Stimulation

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