Resveratrol protects neurons from cannulae implantation injury: Implications for deep brain stimulation

J, Constant; Fraley, Gregory S.; Forbes, Emily; Hallas, Brian H.; Leheste, Joerg R.; Torres, Germán

doi:10.1016/j.neuroscience.2012.06.067

Cited by 11 publications

(10 citation statements)

References 30 publications

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“…Although C57 black mice are less vulnerable than other mouse stains to kainate-induced hippocampal injury and seizure activities ( Schauwecker and Steward, 1997 , McKhann et al, 2003 , McLin and Steward, 2006 ) and we did not observe gross brain lesions in the kindled C57 mice, it is very likely that the hippocampal injury/alterations following kindling seizures as previously demonstrated in rat models occur with varied degrees in our model. In addition, implantations of intra-hippocampal electrodes in our experiments are likely associated with local gliosis, cell injury and/or inflammatory responses as previously demonstrated in other models ( Winslow and Tresco, 2010 , Constant et al, 2012 , Ravikumar et al, 2014 ). The injuries and structural alterations resulting from kindling seizures and the local responses related to electrode implantation may be exacerbated in the aging mice hence attributing to prolonged hippocampal AD and faster motor seizure progression.…”

Section: Discussionsupporting

confidence: 68%

Susceptibility to hippocampal kindling seizures is increased in aging C57 black mice

et al. 2017

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Section: Discussionsupporting

confidence: 68%

Susceptibility to hippocampal kindling seizures is increased in aging C57 black mice

et al. 2017

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“…Naturally derived anti-oxidants, like resveratrol and curcumin, have gained large popularity in the biosciences due to relatively low side effects and the suggested ability of the body to tolerate long-term administration regimes (Sovak, 2001; Bureau et al, 2008). In the central nervous system, anti-oxidants have had success in alleviating detrimental biological events associated with traumatic brain injury (Ates et al, 2006), spinal cord injury (Lin et al, 2011; Liu et al, 2011), ischemia (Lu et al, 2006; Girbovan et al, 2011; Simao et al, 2012), electrode implantation (Constant et al, 2012; Potter et al, 2013; Potter et al, 2014) and disease states such as Parkinson’s and Alzheimer’s (Olanow, 1993; Sun et al, 2010; Wu et al, 2012). …”

Section: Discussionmentioning

confidence: 99%

Implications of chronic daily anti-oxidant administration on the inflammatory response to intracortical microelectrodes

et al. 2015

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Objective Oxidative stress events have been implicated to occur and facilitate multiple failure modes of intracortical microelectrodes. The goal of the present study was to evaluate the ability of a sustained concentration of an anti-oxidant and to reduce oxidative stress-mediated neurodegeneration for the application of intracortical microelectrodes. Approach Non-functional microelectrodes were implanted into the cortex of male Sprague Dawley rats for up to sixteen weeks. Half of the animals received a daily intraperitoneal injection of the natural anti-oxidant resveratrol, at 30 mg/kg. The study was designed to investigate the biodistribution of the resveratrol, and the effects on neuroinflammation/neuroprotection following device implantation. Main Results Daily maintenance of a sustained range of resveratrol throughout the implantation period resulted in fewer degenerating neurons in comparison to control animals at both two and sixteen weeks post implantation. Initial and chronic improvements in neuronal viability in resveratrol-dosed animals were correlated with significant reductions in local superoxide anion accumulation around the implanted device at two weeks after implantation. Controls, receiving only saline injections, were also found to have reduced amounts of accumulated superoxide anion locally and less neurodegeneration than controls at sixteen weeks post-implantation. Despite observed benefits, thread-like adhesions were found between the liver and diaphragm in resveratrol-dosed animals. Significance Overall, our chronic daily anti-oxidant dosing scheme resulted in improvements in neuronal viability surrounding implanted microelectrodes, which could result in improved device performance. However, due to the discovery of thread-like adhesions, further work is still required to optimize a chronic anti-oxidant dosing regime for the application of intracortical microelectrodes.

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“…Immunocytochemical procedures were carried out as described previously (Fraley and Kuenzel, 1993 ; Fraley and Ulibarri, 2002 ; Fraley, 2006 ; Johnson and Fraley, 2008 ; Constant et al, 2012 ). Briefly, brains (n = 5 gonadally active drakes) were collected 4 hrs after lights-on and static-fixed in 4% paraformaldehyde for 72 hrs, then cryoprotected in a 30% sucrose solution (PB; 0.1 M phosphate buffer, pH = 7.4) for 96 h then frozen on dry ice.…”

Section: Methodsmentioning

confidence: 99%

Expression of deep brain photoreceptors in the Pekin drake: a possible role in the maintenance of testicular function

et al. 2017

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Several putative deep brain photoreceptors (DBPs) have been identified, such as melanopsin, opsin 5, and vertebrate ancient opsin. The aim of this study was to elucidate the role of DBPs in gonadal regulation in the Pekin drake. As previously reported, we observed opsin-like immunoreactivity (-ir) in the lateral septum (LS), melanopsin-ir in the premammillary nucleus (PMM), and opsin 5-ir in the periventricular organ. To determine the sensitivity of the DBPs to specific wavelengths of light, drakes were given an acute exposure to red, blue, or white light. Blue light stimulated an increase (P < 0.01) in the immediate early gene fra-2-ir co-expression in melanopsin-ir neurons in the PMM, and red light increased (P < 0.05) fra-2-ir co-expression in opsin-ir neurons, suggesting these neurons are blue- and red-receptive, respectively. To further investigate this photoperiodic response, we exposed drakes to chronic red, long-day white, short-day white, or blue light. Blue light elicited gonadal regression, as testes weight (P < 0.001) and plasma luteinizing hormone (LH) levels (P < 0.001) were lower compared to drakes housed under long-day white light. Photo-regressed drakes experienced complete gonadal recrudescence when housed under long-day red and blue light. qRT-PCR analyses showed that gonadally regressed drakes showed reduced levels (P < 0.01) of gonadotropin releasing hormone (GnRH) mRNA but not photoreceptor or GnIH mRNAs compared to gonadally functional drakes. Our data suggest DBP in the LS may be rhodosin and multiple DBPs are required to fully maintain gonadal function in Pekin drakes.

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Resveratrol protects neurons from cannulae implantation injury: Implications for deep brain stimulation

Cited by 11 publications

References 30 publications

Susceptibility to hippocampal kindling seizures is increased in aging C57 black mice

Susceptibility to hippocampal kindling seizures is increased in aging C57 black mice

Implications of chronic daily anti-oxidant administration on the inflammatory response to intracortical microelectrodes

Expression of deep brain photoreceptors in the Pekin drake: a possible role in the maintenance of testicular function

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