Resveratrol Protects Oxidative Stress-Induced Intestinal Epithelial Barrier Dysfunction by Upregulating Heme Oxygenase-1 Expression

Wang, Na; Han, Qing; Gai, Wang; Ma, Weiping; Jia, Wang; Wu, Wenxin; Guo, Yu; Liu, Li; Jiang, Xiaoyu; Xie, Xing; Jiang, Huiqing

doi:10.1007/s10620-016-4184-4

Cited by 81 publications

(69 citation statements)

References 51 publications

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“…an important topic in the current medical field 42,43) , studies have shown that ischemic stroke can cause an increase in intestinal barrier permeability [44][45][46] . Whether in morphological observation or protein level detection, the intestinal barrier of the Model group was destroyed and the permeability was enhanced.…”

Section: Biological and Pharmaceutical Bulletin Advance Publicationmentioning

confidence: 99%

Protective Effect of Tong-Qiao-Huo-Xue Decoction on Inflammatory Injury Caused by Intestinal Microbial Disorders in Stroke Rats

Zhang

Zhai

Qian

et al. 2020

Biological & Pharmaceutical Bulletin

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Tong-Qiao-Huo-Xue Decoction (TQHXD) is a classic traditional Chinese medicine prescription for treating cerebral ischemia. The purpose of this study was to investigate the effect of TQHXD on intervening inflammatory response of ischemic stroke by regulating intestinal flora and repairing the intestinal barrier. A rat model of cerebral ischemia was established using middle cerebral artery occlusion (MCAO) and behavioral scores were performed. Additionally, the high throughput 16S rDNA sequence of intestinal bacteria in fecal samples of rat was also carried out. Our results showed that TQHXD could change the main components of intestinal flora in stroke rats, and reduced the excessive increase of Bacteroidetes, and also regulated the abnormal changes of abundance of some flora as well. In addition, the intestinal epithelial barrier was damaged after stroke, allowing bacterial metabolites to enter the blood, while TQHXD had an improved effect on this phenomenon. Meanwhile, pathological changes in the brain tissue and infarct volume was also alleviated by TQHXD. Due to the disorder of the intestinal flora and the destruction of the barrier, the peripheral immune imbalance caused an inflammatory reaction. TQHXD improved the imbalance of T cells, and inhibited the inflammatory response. Finally, the therapeutic transplantation of fecal microbiota also improved the outcome of stroke in rats. Our presented results suggest that TQHXD may improve the gut microbiota disorder and its induced inflammatory response after stroke, which could be a new target and mechanism for the treatment of stroke.

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Section: Biological and Pharmaceutical Bulletin Advance Publicationmentioning

confidence: 99%

Protective Effect of Tong-Qiao-Huo-Xue Decoction on Inflammatory Injury Caused by Intestinal Microbial Disorders in Stroke Rats

Zhang

Zhai

Qian

et al. 2020

Biological & Pharmaceutical Bulletin

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“…In the same study, resveratrol increased glutamate cysteine ligase mRNA expression and the ratio of reduced GSH/oxidized GSH (GSSG) and decreased reactive species production. Resveratrol has also been shown to promote hemoxygenase‐1 (HO‐1) expression in vitro and in vivo ; HO‐1, a cytoprotective enzyme against oxidative stress, could possibly interfere with the expression of iNOS and consequent production of NO to ameliorate experimentally induced colitis …”

Section: Beneficial Effects Of Resveratrol On Therapy For Ibdmentioning

confidence: 99%

Resveratrol and inflammatory bowel disease

Shi

Zhou

Jiang

et al. 2017

Annals of the New York Academy of Sciences

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Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, comprising ulcerative colitis (UC) and Crohn's disease (CD). Progression of IBD leads to long-term impairment of intestinal structure and function. The pathogenesis of IBD is complex, involving environmental, immunological, genetic, microbial, and psychological factors. The conventional therapies and many existing biopharmaceuticals for IBD have limited efficacy or adverse effects. As a promising safe and effective therapy for IBD, resveratrol has been studied widely, as it has shown anti-inflammatory and antioxidant activity. Resveratrol's mechanism of action involves multiple immune responses and signaling pathways; it is absorbed quickly and metabolized into various derivatives. However, the poor water solubility and low bioavailability of resveratrol limit its clinical applications. Further research should attempt to improve the stability and oral bioavailability of resveratrol by modification and various delivery systems.

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“…Although the precise inhibitory mechanism of the disruption of intestinal barrier function is still unclear, the possible explanation is that 5‐ALA/SFC directly up‐regulate ZO‐1 expression. In the previous reports, HO‐1 was involved in the regulation of tight junction proteins in oxidative stress–induced endothelial barrier dysfunction such as intestinal epithelial dysfunction (Chi et al., ; He et al., ; Sivasubramaniyam et al., ; Wang et al., , ), blood–spinal cord barrier (Yu et al., ), and pulmonary barrier (Xie et al., ). Additional possibility is regulatory mechanism of cytochrome P450 2E1 (CYP2E1) expression by 5‐ALA/SFC.…”

Section: Discussionmentioning

confidence: 96%

5‐ALA/SFC Attenuated Binge Alcohol–Induced Gut Leakiness and Inflammatory Liver Disease in HIV Transgenic Rats

Liu

Zhu

Fujino

et al. 2019

Alcoholism Clin & Exp Res

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Background: This study aimed to investigate the protective effect of 5-aminolevulinic acid (5-ALA) and sodium ferrous citrate (SFC) against binge alcohol-induced gut leakiness and inflammatory liver disease in HIV transgenic (TG) rats.Methods: TG rats were treated with 3 consecutive doses of binge ethanol (EtOH) with or without 5-ALA/SFC. Blood and liver tissue samples were collected at 6 hours following the last dose of EtOH.Results: Compared with the wild-type (WT) rats, the TG rats showed increased sensitivity to alcohol-mediated inflammation, as evidenced by the significantly elevated levels of serum endotoxin, AST, ALT, ED1, and ED2 staining in liver. In contrast, 5-ALA/SFC improved the above biochemical and histochemical profiles. 5-ALA/SFC also attenuated the up-regulated mRNA expression of leptin and CCL2. Furthermore, down-regulated intestinal ZO-1 protein expression was also inhibited by 5-ALA/ SFC. Moreover, the expressions of HO-1, HO-2, Sirt1, and related signal transduction molecules in liver were increased by 5-ALA/SFC. These results demonstrated that 5-ALA/SFC treatment ameliorated binge alcohol exposure liver injury in a rat model of HIV-infected patients by reducing macrophage activation and expression of inflammatory cytokines/chemokines, and by inducing HO-1, HO-2, and Sirt1 expression.Conclusions: Taken together, these findings suggested that treatment with 5-ALA/SFC has a potential therapeutic effect for binge alcohol exposure liver injury in HIV-infected patients.

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Resveratrol Protects Oxidative Stress-Induced Intestinal Epithelial Barrier Dysfunction by Upregulating Heme Oxygenase-1 Expression

Abstract: Res protected gut barrier function possibly by initiating HO-1-dependent signaling which is essential for common expression of key tight junction proteins. It also provides a rationale to develop Res clinical applications of intestinal disorders.

Cited by 81 publications

References 51 publications

Protective Effect of Tong-Qiao-Huo-Xue Decoction on Inflammatory Injury Caused by Intestinal Microbial Disorders in Stroke Rats

Protective Effect of Tong-Qiao-Huo-Xue Decoction on Inflammatory Injury Caused by Intestinal Microbial Disorders in Stroke Rats

Resveratrol and inflammatory bowel disease

5‐ALA/SFC Attenuated Binge Alcohol–Induced Gut Leakiness and Inflammatory Liver Disease in HIV Transgenic Rats

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