Resveratrol regulates hyperglycemia-induced modulations in experimental diabetic animal model

Rehman, Kanwal; Saeed, Kiran; Munawar, Syeda Mehak; Akash, Muhammad Sajid Hamid

doi:10.1016/j.biopha.2018.03.050

Cited by 31 publications

(32 citation statements)

References 42 publications

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“…Group 1 received only vehicle solution (0.1 % DMSO in saline) as diabetic model group (DM), groups 2-5 treated with the ethanolic extracts of myrrh (EEM) at the doses of 100 mg/kg (EEM100), 200 mg/kg (EEM200), 300 mg/kg (EEM300) and 500 mg/kg (EEM500) respectively, and group 6 received metformin at the dose of 500 mg/kg (MET500). 16 The selection of the studied doses of EEM was based on previous studies reported hypoglycemic activity of myrrh in rats. 10,17 Moreover, eight healthy rats allocated as normal control (NC) group and received just vehicle solution (0.1% DMSO in saline).…”

Section: Induction Of Diabetes and Experimental Designmentioning

confidence: 99%

The Oleo-Gum-Resin of Commiphora myrrha Ameliorates Male Reproductive Dysfunctions in Streptozotocin-Induced Hyperglycemic Rats

et al. 2019

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Background: The oleo-gum-resin of Commiphora myrrha (myrrh) has a long history of therapeutic use in traditional medicine. The aim of this study was to seek for the scientific evidence to determine whether the ethanolic extract of myrrh (EEM) has any beneficial effects on Streptozotocin (STZ) induced testicular impairments, and explore the possible mechanisms underlying such actions. Methods: Forty-eight severe and complicated diabetic rats (fasting blood glucose above 350 mg/dL), randomly were divided into six equal groups (n=8). Besides, eight healthy rats allocated as a normal control group and only treated with vehicle solution. The diabetic animals orally received the extract (100, 200, 300, and 500 mg/kg), metformin (500 mg/kg) or vehicle solution for 28 days. As a final point, plasma glucose and insulin, circulatory sex hormones, sperm parameters including sperm concentration, motility and viability and also testicular malondialdehyde (MDA) levels were assessed. Furthermore, quantitative histological evaluation of seminiferous tubules area and determination of germinal cells apoptosis were performed. Results: None of the studied doses of EEM showed anti-diabetic effects. However, the extract mainly at the maximum dose (500 mg/kg) exhibited beneficial effects on reproductive impairments. The EEM treated rats mainly at 500 mg/kg had significantly higher sperm concentration, sperm motility, sperm viability, sex hormones and lower testicular MDA and germ cell apoptosis index than untreated diabetic rats. Conclusion: These results indicated that EEM may have beneficial effects against reproductive dysfunction induced by diabetes. The mechanisms behind the effects might be associated with the EEM sex hormone booster potential, antioxidant and anti-apoptotic properties.

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Section: Induction Of Diabetes and Experimental Designmentioning

confidence: 99%

The Oleo-Gum-Resin of Commiphora myrrha Ameliorates Male Reproductive Dysfunctions in Streptozotocin-Induced Hyperglycemic Rats

et al. 2019

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“…Nevertheless, such evidence was confirmed in vivo [26,42,44,50,55], with data supporting the strong potential for both compounds to attenuate diabetes-linked abnormalities equally in STZ or HFD-fed induced models, representing T1D and T2D, respectively. Moreover, some of the data demonstrated that resveratrol might be more protective than metformin in vivo [54,56,57], however, these are only preliminary findings this aspect needs further exploration using well-designed experiments.…”

Section: Discussionmentioning

confidence: 95%

“…In heart tissue, resveratrol, and strength training, decreased the plin5 expression, but metformin increased the gene expression. In skeletal muscle, resveratrol, strength training, cold and metformin significantly increased the plin5 expression at the gene and protein level Rehman et al 2018 [57] Alloxan-induced albino rats received metformin (500 mg/kg/day) or resveratrol (30 mg/kg/day) for 30 days Resveratrol alone and/or in combination with vitamin E exhibited a highly significant therapeutic potential by ameliorating the glycemia-induced modulations. Moreover, resveratrol in combination with vitamin E also exhibited a better therapeutic effects when compared with that of metformin Several studies assessed the comparative effects of metformin and resveratrol through the use of chemicals such as STZ and alloxan to induce diabetes-associated complications (Table 2).…”

Section: In Vivo Evidence On the Comparative Effects Of Metformin Witmentioning

confidence: 99%

“…Other studies consistently reported on comparative outcomes with the use of both compounds in improving metabolic profiles, ameliorating hepatic and pancreatic β-cell damage, and blocking oxidative stress [25,52]. Attenuation of ROS production, with activation of AMPK, were the predominant mechanism associated with the activity of metformin and resveratrol Interestingly, in alloxan-induced diabetic rats, supplementation with resveratrol alone or in combination with vitamin E for 30 days provided a better effect than metformin in ameliorating the hyperglycemia-induced complications [57]. Thus, suggesting that resveratrol could offer synergistic effects in ameliorating diabetes-associated complications when used in combination with other antioxidant compounds.…”

Section: In Vivo Evidence On the Comparative Effects Of Metformin Witmentioning

confidence: 99%

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Exploring the Comparative Efficacy of Metformin and Resveratrol in the Management of Diabetes-Associated Complications: A Systematic Review of Preclinical Studies

et al. 2020

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Food-derived bioactive compounds such as resveratrol are increasingly explored for their protective effects against metabolic complications. Evidence supports the strong antioxidant properties and therapeutic effects of resveratrol in managing diabetes and its associated complications. However, evidence informing on the comparative or combination effects of this natural compound with an accomplished and well-characterized antidiabetic agent like metformin has not been revised. Thus, we conducted a comprehensive systematic search of the major electronic databases which included MEDLINE, Cochrane Library, and EMBASE. The cumulative evidence strongly supports the comparative effects of metformin and resveratrol in ameliorating diabetes-associated complications in preclinical settings. In particular, both compounds showed strong ameliorative effects against hyperglycemia, dyslipidemia, insulin resistance, a pro-inflammatory response, and lipid peroxidation in various experimental models of diabetes. Enhancing intracellular antioxidant capacity in addition to activating NAD-dependent deacetylase sirtuin-1 (SIRT1) and AMP-activated protein kinase (AMPK) are the prime mechanisms involved in the therapeutic effects of these compounds. Of interest, preclinical evidence also demonstrates that the combination treatment with these compounds may have a greater efficacy in protecting against diabetes. Thus, confirmation of such evidence in well-organized clinical trials remains crucial to uncover novel therapeutic strategies to manage diabetes and its linked complications.

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“…Hence, diabetes mellitus is accompanied with excessive oxidative stress on one hand and reduced levels of naturally occurring anti-oxidants on the other. Thus, the treatment approach which includes the administration of an anti-oxidant drug to overcome the oxidative stress upon various vital organs could be successful, as reported in previous studies where resveratrol, a phenolic antioxidant has exhibited significant therapeutic potential against diabetes mellitus [3,4].…”

Section: Introductionmentioning

confidence: 93%

Design, optimization, characterization and in-vivo evaluation of Quercetin enveloped Soluplus®/P407 micelles in diabetes treatment

Singh

Moteriya

Bonde

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Quercetin (Qu), is a flavonoid known to have anti-diabetic effects owing to its antioxidant property, thus promoting regeneration of the pancreatic islets, ultimately increasing insulin secretion. But the therapeutic application of Qu is hampered by its low oral bioavailability and its unfavourable physicochemical characteristics. The present work aimed at formulation of Quercetin loaded SoluplusV R micelles (SMs) so as to enhance its bioavailability and provide prolonged release for the management of diabetes. Box-Behnken response surface methodology was employed to optimize the formulation prepared using co-solvent evaporation method. Physicochemical characterization confirmed the nanospherical nature of Quercetin loaded SoluplusV R micelles (Qu-SMs) with average particle size ranging from 85-108nm, encapsulation efficiency of 63-77%. Solid state characterization confirmed the encapsulation of Qu in the micelles without any incompatibilities. Moving forward, the results of in vitro study revealed prolonged and slow release of Qu from the developed formulations. The in vivo pharmacokinetic study revealed improved bioavailability by enveloping the drug in SMs. Moreover, the study performed to evaluate the efficiency in diabetes treatment revealed an enhanced anti-diabetic effect. Thus, Qu-SMs can serve as potential carriers aimed at improving the anti-diabetic property of Qu.

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Resveratrol regulates hyperglycemia-induced modulations in experimental diabetic animal model

Cited by 31 publications

References 42 publications

The Oleo-Gum-Resin of Commiphora myrrha Ameliorates Male Reproductive Dysfunctions in Streptozotocin-Induced Hyperglycemic Rats

The Oleo-Gum-Resin of Commiphora myrrha Ameliorates Male Reproductive Dysfunctions in Streptozotocin-Induced Hyperglycemic Rats

Exploring the Comparative Efficacy of Metformin and Resveratrol in the Management of Diabetes-Associated Complications: A Systematic Review of Preclinical Studies

Design, optimization, characterization and in-vivo evaluation of Quercetin enveloped Soluplus®/P407 micelles in diabetes treatment

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