Resveratrol regulates the recovery of rat sciatic nerve crush injury by promoting the autophagy of Schwann cells

Zhang, Jiayi; Ren, Jingyan; Liu, Yang; Huang, Dong-Xu; Lu, Laijin

doi:10.1016/j.lfs.2020.117959

Cited by 22 publications

(14 citation statements)

References 31 publications

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“…Although its mechanism of action remains unclear, RSV is believed to promote autophagy via its interactions with signaling pathways associated with mTOR, AMPK, SIRT1, PI3K/Akt, and MAPK. RSV also suppresses the TLR4/NF-κB signaling to activate autophagy, thereby accelerating clearance and promoting regeneration (14). Administration of RSV may thus be an effective strategy for the treatment of PNS and CNS injury.…”

Section: Resveratrolmentioning

confidence: 99%

Review: Myelin clearance is critical for regeneration after peripheral nerve injury

Yuan

Wang

et al. 2022

Front. Neurol.

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Traumatic peripheral nerve injury occurs frequently and is a major clinical and public health problem that can lead to functional impairment and permanent disability. Despite the availability of modern diagnostic procedures and advanced microsurgical techniques, active recovery after peripheral nerve repair is often unsatisfactory. Peripheral nerve regeneration involves several critical events, including the recreation of the microenvironment and remyelination. Results from previous studies suggest that the peripheral nervous system (PNS) has a greater capacity for repair than the central nervous system. Thus, it will be important to understand myelin and myelination specifically in the PNS. This review provides an update on myelin biology and myelination in the PNS and discusses the mechanisms that promote myelin clearance after injury. The roles of Schwann cells and macrophages are considered at length, together with the possibility of exogenous intervention.

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Section: Resveratrolmentioning

confidence: 99%

Review: Myelin clearance is critical for regeneration after peripheral nerve injury

Yuan

Wang

et al. 2022

Front. Neurol.

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“…The natural component known as polyphenol is regularly consumed and is attracting increasing interest due to its medicinal properties and other possible beneficial applications. Many plant species, such as grapes and berries, contain the secondary plant metabolite Resveratrol (RES; trans-stilbene), which plays the role of a phytoalexin ( Zhang et al, 2020 ). Many studies have shown that RES has antioxidant properties, reduces inflammation, and slows cellular ageing, positively affecting cardiovascular disease, metabolic disease, inflammation, and cognitive function ( Jang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Anticholinergic effect of resveratrol with vitamin E on scopolamine-induced Alzheimer’s disease in rats: Mechanistic approach to prevent inflammation

Foudah

Devi²,

Alam³

et al. 2023

Front. Pharmacol.

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The most common form of dementia, Alzheimer’s disease (AD), is characterized by gradual declines in cognitive abilities and behavior. It is caused by a combination of factors, including amyloid-β (Aβ) accumulation, acetylcholine (ACh) loss, oxidative stress, and inflammation. Phenolic compounds have a variety of health benefits, including antioxidant activities. Thus, the purpose of this study was to investigate how resveratrol (RES) alone and in combination with vitamin E affected rats with AD using scopolamine (SCO). Animals are categorized into groups; (i) control, (ii) SCO (1 mg/kg i.p.), (iii) SCO + donepezil, (iv) SCO + RES (50 mg/kg, p.o.), (v) SCO + RES (75 mg/kg, p.o.), (vi) SCO + RES (50 mg/kg + vitamin E 1 mg/kg, p.o.) for 17 days. In rats, studied behavioural (NOR and EPM) and biochemical characteristics. In addition, brain histopathology was examined to investigate any damage to the hippocampus and neuroprotection. SCO-induced changes in acetylcholinesterase, protein carbonyl, and TNF-α improved after resveratrol treatment. RES increased antioxidant levels, decreased SCO-induced lipid peroxidation, and reversed SCO-mediated changes compared with the drug donepezil. The results indicated that RES and vitamin E had nootropic action in the NOR and EPM tests, measured by the recognition index and the inflection ratio. This study supports the efficacy of RES as a preventive and treatment agent for AD. Vitamin E showed a synergistic effect on RES, which helps in managing cognitive impairment AD.

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“…Hands are the main organs of labor and work, and most work crush injuries occur in both hands or arms [ 1 , 2 ]. Hand injury will seriously affect people's daily life and social work, bringing physical pain and economic burden to patients [ 3 , 4 ]. The pressure injury of the hand has a great impact on the hand, and it takes a long time to recover the wound, which is prone to form chronic refractory wounds so that the wound cannot be properly repaired.…”

Section: Introductionmentioning

confidence: 99%

Effect and Mechanism of Dragon’s Blood on Wound Healing of Patients with Stress Hand Injury

Sun

Wang

Yue

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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This study aimed to explore the effect and mechanism of Dragon’s Blood on wound healing in patients with a pressure hand injury. A total of 120 patients with pressure hand injury treated in our hospital were randomly divided into two groups. Sixty patients in the control group were dressed with sterile gauze, and 60 patients in the observation group were smeared with blood exhaustion. The clinical effects and serological indexes of the two groups were compared, and the mechanism of wound healing was analyzed. The results showed that the treatment effective rate of the control group was 80% and that of the observation group was 93.33%. The treatment effective rate of the observation group was dramatically higher ( P < 0.05 ). The number of patients with good granulation tissue in the observation group was 53, which was dramatically greater than that in the control group. The number of patients with a small amount of wound exudation was 51, which was dramatically greater than that in the control group ( P < 0.05 ). After treatment, the levels of matrix metalloproteinase (MMP-3), vascular endothelial growth factor (VEGF), and transforming growth factor B1 (TGF-B1) in the observation group increased more dramatically ( P < 0.05 ). The level of tissue inhibitor of metalloproteinase-1 (TIMP-1) decreased to 617.23 ng/L in the observation group, and the degree of reduction was more obvious ( P < 0.05 ). Notably, Dragon’s Blood promoted wound healing at the injury site by increasing the levels of MMP-3, VEGF, and TGF-B1and decreasing TIMP-1. The area of wound reduction in the observation group was 0.27 cm2, and the reduction was more obvious ( P < 0.05 ). The healing time of pressure hand injury in the observation group was 15.27 days, which was dramatically shorter ( P < 0.05 ). In summary, Dragon’s Blood had a good effect on the healing of the injured site in patients with pressure hand injury, which is worthy of promotion.

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Resveratrol regulates the recovery of rat sciatic nerve crush injury by promoting the autophagy of Schwann cells

Cited by 22 publications

References 31 publications

Review: Myelin clearance is critical for regeneration after peripheral nerve injury

Review: Myelin clearance is critical for regeneration after peripheral nerve injury

Anticholinergic effect of resveratrol with vitamin E on scopolamine-induced Alzheimer’s disease in rats: Mechanistic approach to prevent inflammation

Effect and Mechanism of Dragon’s Blood on Wound Healing of Patients with Stress Hand Injury

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