Resveratrol Role in Autoimmune Disease—A Mini-Review

Oliveira, Ana Lígia de Brito; Monteiro, Valter Silva; Navegantes-Lima, Kely Campos; Reis, Jordano Ferreira; Gomes, Rafaelli de Souza; Rodrigues, Dávila Valentina Silva; Gaspar, Silvia Letícia de França; Monteiro, Marta Chagas

doi:10.3390/nu9121306

Cited by 118 publications

(72 citation statements)

References 140 publications

(162 reference statements)

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“…[19][20][21] In addition, the dysregulation between pro-inflammatory cytokines and anti-inflammatory cytokines further aggravates mucosal inflammation in IBD. 22) Therefore, inhibition of intestinal inflammation plays a vital role in the treatment of IBD.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Attenuates Inflammatory Bowel Disease in Mice by Regulating SUMO1

Wang

Zhang²,

Fang

et al. 2020

Biological & Pharmaceutical Bulletin

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Resveratrol (Res) is a natural active antioxidant that is effective in relieving inflammatory bowel disease (IBD). However, the specific mechanism for its function is unknown. In our study, dextran sodium sulfate (DSS)-induced mouse IBD disease model was constructed. All mice were randomly divided into three groups. The treatment effects of resveratrol on IBD were evaluated by observing the body weight, fecal traits, colon/ spleen gross appearance, tissue hematoxylin-eosin (H&E)/immunohistochemistry (IHC) and inflammatory factors. The expression of small ubiquitin-like modifier protein 1 (SUMO1) and its Wnt/β-catenin pathwayrelated genes was analyzed by IHC, Western blot, Real-time PCR (RT-PCR) and Immunofluorescence. The outcome indicated that resveratrol treatment significantly relieved the symptoms of IBD. The expression level of anti-inflammatory cytokines was increased while that of pro-inflammatory cytokines was decreased in both colon and spleen tissues of resveratrol-treated mice. SUMO1 expression and Wnt/β-catenin pathway were suppressed in colon and spleen tissues of IBD mice treated with resveratrol. In addition, we provided evidence that resveratrol inhibited SUMO1 and β-catenin expression and their nuclear localization in human colonic epithelial cell line (FHC). Moreover, we found that SUMO1 and β-catenin had higher expression levels in colorectal cancer patients than in health and colitis patients. In conclusions, resveratrol alleviates DSSinduced IBD by modulating SUMO1 through Wnt/β-catenin pathway.

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Section: Discussionmentioning

confidence: 99%

Resveratrol Attenuates Inflammatory Bowel Disease in Mice by Regulating SUMO1

Wang

Zhang²,

Fang

et al. 2020

Biological & Pharmaceutical Bulletin

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“…Cellular Physiology and Biochemistry therapeutic option in some organ-specific or systemic autoimmune diseases [24]. RSV is selectively toxic for a wide variety of tumor cells, but is helpful for the growth of a certain number of normal cells, such as endothelial cells, lymphocytes, and chondrocytes [25].…”

Section: Cellular Physiology and Biochemistrymentioning

confidence: 99%

Resveratrol Protects Murine Chondrogenic ATDC5 Cells Against LPS-Induced Inflammatory Injury Through Up-Regulating MiR-146b

Jin

Zhang²,

et al. 2018

Cell Physiol Biochem

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Background/Aims: Resveratrol (RSV) has been reported as a promising oral supplementation for osteoarthritis treatment, while the mechanism of its action is still unclear. The specific aim of this study is to decode one of the mechanisms by which RSV protects chondrocyte. Methods: Mouse chondrogenic cell line ATDC5 was treated with 30 µM RSV for 24 h, and 10 µg/ml LPS for 12 h, after which cell viability, apoptosis, and the release of pro-inflammatory cytokines were assessed. The expression of miR-146b in ATDC5 cells was silenced by the specific inhibitor transfection, and then cell viability, apoptosis and inflammation were re-assessed. Results: The IC50 value of LPS in ATDC5 cells was about 10.27 µg/ml. LPS with a dosage of 10 µg/ml repressed cell viability, induced apoptosis, and increased the release of IL-1β, IL-6 and TNF-α. RSV pre-treatment (30 µM) significantly alleviated LPS-induced apoptosis and inflammation. More importantly, miR-146b was up-regulated by RSV, and the protective functions of RSV on ATDC5 cells were attenuated by miR-146b silence. Further, NF-κB and p38MAPK pathways were activated by LPS, and were deactivated by RSV. Besides, RSV-induced the deactivation of NF-κB and p38MAPK pathways was reversed by miR-146b silence. Conclusions: Our findings suggest that RSV protects ATDC5 cells from LPS-induced inflammatory and apoptotic injury via up-regulation of miR-146b and thereby deactivation of NF-κB and p38MAPK pathways.

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“…Previous studies have shown that resveratrol has several anti‐inflammatory effects . In the CIA model, we found that resveratrol inhibited Src tyrosine kinase, STAT3, and Wnt signaling pathways, resveratrol‐ameliorated inflammatory arthritis.…”

Section: Discussionmentioning

confidence: 54%

Resveratrol inhibits Src tyrosine kinase, STAT3, and Wnt signaling pathway in collagen induced arthritis model

et al. 2018

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Resveratrol, a phytochemical, acts several cellular signaling pathways and has anti‐inflammatory potentials. The purpose of this study is to research the therapeutic effect of resveratrol in collagen‐induced arthritis (CIA) model in rats and whether resveratrol affects the activities of signaling pathways those are potent pathogenic actors of rheumatoid arthritis. Arthritis was induced by intradermal injection of chicken type II collagen combined with incomplete Freund's adjuvant in Wistar albino rats. One day after the onset of arthritis (day 14), resveratrol (20 mg/kg/day) was given via oral gavage, until day 29. The paws of the rats were obtained for further analysis. Tissue Wnt5a, mitogen‐activated protein kinase (MAPK), Src tyrosine kinase and signal transducer, and activator of transcription‐3 (STAT3) mRNA expressions were determined by real‐time polymerase chain reaction. Resveratrol ameliorated the clinical and histopathological (perisynovial inflammation and cartilage‐bone destruction) findings of inflammatory arthritis. The tissue mRNA expressions of Wnt5a, MAPK3, Src kinase, and STAT3 were increased in the sham group compared to the control group. Resveratrol supplement decreased their expressions. The present study shows that Src kinase, STAT3, and Wnt signaling pathway are active in the CIA model. Resveratrol inhibits these signaling pathways and ameliorates inflammatory arthritis. © 2018 BioFactors, 45(1):69–74, 2019

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Resveratrol Role in Autoimmune Disease—A Mini-Review

Cited by 118 publications

References 140 publications

Resveratrol Attenuates Inflammatory Bowel Disease in Mice by Regulating SUMO1

Resveratrol Attenuates Inflammatory Bowel Disease in Mice by Regulating SUMO1

Resveratrol Protects Murine Chondrogenic ATDC5 Cells Against LPS-Induced Inflammatory Injury Through Up-Regulating MiR-146b

Resveratrol inhibits Src tyrosine kinase, STAT3, and Wnt signaling pathway in collagen induced arthritis model

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