Resveratrol (RV): A pharmacological review and call for further research

Zhang, Lixue; Li, Changxing; Kakar, Mohib Ullah; Khan, Muhammad Sajjad; Wu, Peifeng; Amir, Rai Muhammad; Dai, Dongfang; Naveed, Muhammad; Li, Qinyuan; Saeed, Muhammad; Shen, Ji-Qiang; Rajput, Shahid Ali; Li, Jianhua

doi:10.1016/j.biopha.2021.112164

Cited by 257 publications

(138 citation statements)

References 188 publications

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“…Medicinal plants have been used in healthcare for a long time, and their use to prevent and treat illness is expanding worldwide ( Dhama et al, 2018 ; Bilal et al, 2021 ; Reda et al, 2021 ; Saeed et al, 2021 ). The medicinal properties of plants are due to the natural chemicals/compounds they contain ( Saeed et al, 2019 ; Alagawany et al, 2021c ; Garg et al, 2021 ; Zhang et al, 2021 ). Plants are a source of food and act as raw materials from which a variety of drugs are synthesized ( Hassan, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Citrullus colocynthis (L.) Schrad (Bitter Apple Fruit): Promising Traditional Uses, Pharmacological Effects, Aspects, and Potential Applications

Munawar

Saeed

et al. 2022

Front. Pharmacol.

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Health consciousness and increased knowledge about the side effects of synthetic drugs have enhanced interest in traditional medicines. Medicinal plants offer cures for various diseases, leading to improved living standards. This has brought ethnomedicinal studies into the spotlight and increased demand for herb-based medicines. Citrullus colocynthis is an herbaceous plant containing an abundance of nutrients that play a key role in the improvement of wellbeing. C. colocynthis has many biological properties, such as antioxidative, hypoglycemic, antibacterial, anti-cancerous, anti-inflammatory, analgesic, gastrointestinal tract, reproduction, protection, anti-microbial, antidiabetic, hypolipidemic, antineoplastic, profibrinolytic, anti-allergic, pesticidal, and immune-stimulatory. There are numerous bioactive compounds like cucurbitacin, flavonoids, and polyphenols in C. colocynthis that give it medicinal properties. Herein, we have extensively compiled, reviewed, and analyzed significant information on C. colocynthhis from the best published available evidence in PubMed, Scopus (Embase), Web of Science (Web of Knowledge), Cochrane Library, and Google Scholar, etc. Scientific literature evidenced that owing to the bioactive constituents, including cucurbitacin, polyphenols, flavonoids, and other potent molecules, C. colocynthis has many pharmacological and physiological functions. It possesses multi-beneficial applications in treating various disorders of humans and animals. So, the primary purpose of this comprehensive review is to provide an overview of the findings of positive impacts and risks of C. colocynthis consumption on human health, especially in poultry and veterinary fields. In the future, this narrative article will be aware of discoveries about the potential of this promising natural fruit and its bioactive compounds as the best nutraceuticals and therapeutic drugs in veterinary and human medicine.

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Section: Introductionmentioning

confidence: 99%

Citrullus colocynthis (L.) Schrad (Bitter Apple Fruit): Promising Traditional Uses, Pharmacological Effects, Aspects, and Potential Applications

Munawar

Saeed

et al. 2022

Front. Pharmacol.

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“…This issue is still a topic among scientific discussions. Recently, Zhang, et al [ 9 ] reviewed the pharmacological literature regarding resveratrol and called for further research.…”

Section: Introductionmentioning

confidence: 99%

On Health Effects of Resveratrol in Wine

Haunschild

Marx

2022

IJERPH

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We analyzed 3344 publications concerned with the health-related effects of resveratrol that occurs in wine and grapes. We discovered that publication activity increased until 2010 and decreased slightly afterwards. The most frequent author keywords were classified into six groups: (1) beverage-related keywords, (2) compound-related keywords, (3) disease-related keywords, (4) effect-related keywords, (5) mechanism-related keywords, and (6) broader keywords. By means of reference publication year spectroscopy, we analyzed and discussed the most frequently cited references (i.e., key papers) within the publication set. A rather large portion of the key papers exhibit a deliberative or positive attitude and report on the health effects of resveratrol, although limited data in humans preclude drawing unambiguous conclusions on its health-related benefits. From our analysis, we could not identify specific publications that provide a distinct change of direction of the ongoing scientific discourse. Moderate red wine consumption seems to bear the potential of being health promoting, whereas excessive alcohol consumption can induce liver cirrhosis and cancer.

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“…Thus, current studies focus on the inhibitory effect of various antioxidant molecules on the invasive potential of cancer cells [ 16 ]. One example is the preventive cancer agent Resveratrol (RSV) [3,5,4′-trihydroxytrans- stilbene], a widely recognized antioxidant molecule with a demonstrated anticancer potential against several types of cancers, including prostate, hepatic, breast, skin, colorectal, and pancreatic cancer [ 17 , 18 , 19 ]. The reported effect of RSV against malignant cells in vitro and in vivo has been ascribed to its antioxidant and anti-inflammatory activities [ 20 , 21 , 22 ], which interferes with signal transduction pathways, for instance, by increasing antioxidant mediators such as Catalase and Superoxide dismutase, inhibiting angiogenesis, modulating cell cycle regulators, and inducing selective apoptosis [ 23 , 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Decreases the Invasion Potential of Gastric Cancer Cells

et al. 2022

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The cancer-preventive agent Resveratrol (RSV) [3,5,4′-trihydroxytrans-stilbene] is a widely recognized antioxidant molecule with antitumoral potential against several types of cancers, including prostate, hepatic, breast, skin, colorectal, and pancreatic. Herein, we studied the effect of RSV on the cell viability and invasion potential of gastric cancer cells. AGS and MKN45 cells were treated with different doses of RSV (0–200 μM) for 24 h. Cell viability was determined using the Sulphorhodamine B dye (SRB) assay. For invasion assays, gastric cells were pre-treated with RSV (5–25 μM) for 24 h and then seeded in a Transwell chamber with coating Matrigel. The results obtained showed that RSV inhibited invasion potential in both cell lines. Moreover, to elucidate the mechanism implicated in this process, we analyzed the effects of RSV on SOD, heparanase, and NF-κB transcriptional activity. The results indicated that RSV increased SOD activity in a dose-dependent manner. Conversely, RSV significantly reduced the DNA-binding activity of NF-κB and the enzymatic activity of heparanase in similar conditions, which was determined using ELISA-like assays. In summary, these results show that RSV increases SOD activity but decreases NF-kB transcriptional activity and heparanase enzymatic activity, which correlates with the attenuation of invasion potential in gastric cancer cells. To our knowledge, no previous study has described the effect of RSV on heparanase activity. This article proposes that heparanase could be a key effector in the invasive events occurring during gastric cancer metastasis.

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Resveratrol (RV): A pharmacological review and call for further research

Cited by 257 publications

References 188 publications

Citrullus colocynthis (L.) Schrad (Bitter Apple Fruit): Promising Traditional Uses, Pharmacological Effects, Aspects, and Potential Applications

Citrullus colocynthis (L.) Schrad (Bitter Apple Fruit): Promising Traditional Uses, Pharmacological Effects, Aspects, and Potential Applications

On Health Effects of Resveratrol in Wine

Resveratrol Decreases the Invasion Potential of Gastric Cancer Cells

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