Resveratrol Supplementation and Oxidative/Anti-Oxidative Status in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study

Samsamikor, Maryam; Daryani, Naser Ebrahimi; Asl, Parisa Rezanejad; Hekmatdoost, Azita

doi:10.1016/j.arcmed.2016.07.003

Cited by 115 publications

(85 citation statements)

References 23 publications

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“…Determining sample size for this study was based on detection of four score difference in mean SCCAIQ score with power of 80% (β = 20%) (Samsamikor, Daryani, Asl, & Hekmatdoost, ). In this study, the calculated sample size for each group was 21 patients.…”

Section: Methodsmentioning

confidence: 99%

The effects of Nigella sativa on quality of life, disease activity index, and some of inflammatory and oxidative stress factors in patients with ulcerative colitis

Nikkhah-Bodaghi

Darabi

Agah

et al. 2019

Phytotherapy Research

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The aim of this study was to evaluate the effects of Nigella sativa (NS) supplementation in patients with ulcerative colitis. Two grams of NS powder or placebo were consumed for 6 weeks by 46 patients with active mild to moderate ulcerative colitis.Using valid and common questionnaires of colitis severity and blood sampling, we estimated disease activity index, quality of life, and some of inflammatory and oxidative stress factors at baseline and after 6 weeks of supplementation. NS-elevated tumor necrosis factor-alpha and high-sensitivity-c-reactive-protein as well as reduced malondialdehyde (p = 0.01, p = 0.02, and p = 0.005, respectively) compared with placebo. There was no significant difference between the two groups in serum total antioxidant capacity and nuclear factor kB levels. Total scores of Simple Clinical Colitis Activity Index Questionnaire and Inflammatory Bowel Disease Questionnaire-9were not different between the two groups; however, stool frequency score decreased significantly in NS group. Further clinical trials with different pattern of NS administration (the amount of total and divided daily doses, either powder type or standard extracts/oil and different time arrangement) are needed to clarify the vision.

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Section: Methodsmentioning

confidence: 99%

The effects of Nigella sativa on quality of life, disease activity index, and some of inflammatory and oxidative stress factors in patients with ulcerative colitis

Nikkhah-Bodaghi

Darabi

Agah

et al. 2019

Phytotherapy Research

Self Cite

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“…Recently, several double‐blind placebo‐controlled randomized clinical trials have reported that supplementation with resveratrol (500 mg/day) can reduce plasma levels of inflammatory biomarkers and inhibit NF‐κB activation in peripheral blood mononuclear cells, while increasing antioxidant activity and suppressing oxidative stress in UC patients. Although resveratrol has some beneficial effects in mild‐to‐moderate UC, it improves clinical colitis activity and patient quality of life to some extent …”

Section: Beneficial Effects Of Resveratrol On Therapy For Ibdmentioning

confidence: 99%

Resveratrol and inflammatory bowel disease

Shi

Zhou

Jiang

et al. 2017

Annals of the New York Academy of Sciences

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Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, comprising ulcerative colitis (UC) and Crohn's disease (CD). Progression of IBD leads to long-term impairment of intestinal structure and function. The pathogenesis of IBD is complex, involving environmental, immunological, genetic, microbial, and psychological factors. The conventional therapies and many existing biopharmaceuticals for IBD have limited efficacy or adverse effects. As a promising safe and effective therapy for IBD, resveratrol has been studied widely, as it has shown anti-inflammatory and antioxidant activity. Resveratrol's mechanism of action involves multiple immune responses and signaling pathways; it is absorbed quickly and metabolized into various derivatives. However, the poor water solubility and low bioavailability of resveratrol limit its clinical applications. Further research should attempt to improve the stability and oral bioavailability of resveratrol by modification and various delivery systems.

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“…In a double-blind trial supplementation of RES to UC patients (500 mg/day for 6 weeks) reduced NF-B expression in peripheral blood mononuclear cells, TNF- and C-rp plasma levels were detected [255]. The effects exerted by polyphenols on allergy and autoimmune diseases are synthesized in Table 7.…”

Section: Allergy and Autoimmune Diseasesmentioning

confidence: 99%

Recent Advances on the Anti-inflammatory and Anti-oxidant properties of Red Grape Polyphenols: In Vitro and in Vivo Studies

Magrone¹,

Magrone²,

Russo³

et al. 2019

Preprint

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In this review, special emphasis will be placed on red grape polyphenols for their anti-oxidant and anti-inflammatory activities. Therefore, their capacity to inhibit major pathways responsible for activation of oxidative systems and expression and release of pro-inflammatory cytokines and chemokines will be discussed. Furthermore, regulation of immune cells by polyphenols will be illustrated with special reference to the activation of T regulatory cells which support a tolerogenic pathway at intestinal level. Furthermore, the effects of red grape polyphenols will be analyzed in obesity, as a low grade systemic inflammation. Also, possible modifications of inflammatory bowel disease biomarkers and clinical course have been studied upon polyphenol administration, either in animal models or in clinical trials. Moreover, the ability of polyphenols to cross the blood-brain barrier has been exploited to investigate their neuroprotective properties. In cancer, polyphenols seem to exert several beneficial effects, even if conflicting data are reported about their influence on T regulatory cells. Finally, the effects of polyphenols have been evaluated in experimental models of allergy and autoimmune diseases. Conclusively, red grape polyphenols are endowed with a great anti-oxidant and anti-inflammatory potential but some issues, such as polyphenol bioavailability, activity of metabolites and interaction with microbiota, deserve deeper studies.

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Resveratrol Supplementation and Oxidative/Anti-Oxidative Status in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study

Cited by 115 publications

References 23 publications

The effects of Nigella sativa on quality of life, disease activity index, and some of inflammatory and oxidative stress factors in patients with ulcerative colitis

The effects of Nigella sativa on quality of life, disease activity index, and some of inflammatory and oxidative stress factors in patients with ulcerative colitis

Resveratrol and inflammatory bowel disease

Recent Advances on the Anti-inflammatory and Anti-oxidant properties of Red Grape Polyphenols: In Vitro and in Vivo Studies

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