Resveratrol supplementation does not augment performance adaptations or fibre-type–specific responses to high-intensity interval training in humans

Abstract

The present study examined the effect of concurrent exercise training and daily resveratrol (RSV) supplementation (150 mg) on training-induced adaptations following low-dose high-intensity interval training (HIIT). Sixteen recreationally active (∼22 years, ∼51 mL·kg(-1)·min(-1)) men were randomly assigned in a double-blind fashion to either the RSV or placebo group with both groups performing 4 weeks of HIIT 3 days per week. Before and after training, participants had a resting muscle biopsy taken, completed a peak oxygen uptake test, a Wingate test, and a submaximal exercise test. A main effect of training (p < 0.05) and interaction effect (p < 0.05) on peak aerobic power was observed; post hoc pairwise comparisons revealed that a significant (p < 0.05) increase occurred in the placebo group only. Main effects of training (p < 0.05) were observed for both peak oxygen uptake (placebo - pretraining: 51.3 ± 1.8, post-training: 54.5 ± 1.5 mL·kg(-1)·min(-1), effect size (ES) = 0.93; RSV - pretraining: 49.6 ± 2.2, post-training: 52.3 ± 2.5 mL·kg(-1)·min(-1), ES = 0.50) and Wingate peak power (placebo: pretraining: 747 ± 39, post-training: 809 ± 31 W, ES = 0.84; RSV - pretraining: 679 ± 39, post-training: 691 ± 43 W, ES = 0.12). Fibre-type distribution was unchanged, while a main effect of training (p < 0.05) was observed for succinate dehydrogenase activity and glycogen content, but not α-glycerophosphate dehydrogenase activity or intramuscular lipids in type I and IIA fibres. The fold change in PGC-1α, SIRT1, and SOD2 gene expression following training was significantly (p < 0.05) lower in the RSV group than placebo. These results suggest that concurrent exercise training and RSV supplementation may alter the normal training response induced by low-volume HIIT.

High-intensity interval and endurance training are associated with divergent skeletal muscle adaptations in a rodent model of hypertension

“…These adaptations were more robust in type I fibers, as only type I fibers in the RG displayed an increase in SDH activity. These data support previous work in healthy individuals, which has shown that both ET and HIIT increase various markers of mitochondrial content and have a similar response in type I and II fibers (47,49). It was surprising that neither ET nor HIIT increased CS activity in the current study in the RG.…”

Comprehensive Metabolomic Analysis in Blood, Urine, Fat, and Muscle in Men with Metabolic Syndrome: A Randomized, Placebo-Controlled Clinical Trial on the Effects of Resveratrol after Four Months’ Treatment

“…This finding ties in well with the study by Olesen et al [32], in which resveratrol blunted the positive effects of exercise training. In contrast, Scribbans et al found that resveratrol in addition to exercise had positive effects on muscle metabolism with an increase in mitochondrial capacity [33], while others found no effect in humans [34]. Most rodent studies have found positive effects of resveratrol on muscle function [5,35,36].…”

New strategies in sport nutrition to increase exercise performance

“…As such, there is growing support that resveratrol may be a beneficial approach to remodel skeletal muscle in humans. Whilst the data from Timmers et al (2011) was encouraging, recently Scribbans and colleagues (2014) reported that resveratrol supplementation during exercise training in healthy individuals can result in a maladaptive response in exercise-stimulated gene expression [176]. In agreement with this observation, Gliemann et al (2013) showed that resveratrol supplementation in combination with high-intensity training in older men not only blunted the increase in maximal oxygen uptake observed in the placebo group, but also eradicated the effects of the exercise to reduce low-density lipoprotein, total cholesterol and triglyceride concentrations in the blood [177].…”