Resveratrol supplementation improves metabolic control in rats with induced hyperlipidemia and type 2 diabetes

Rašković, Aleksandar; Ćućuz, Veljko; Torović, Ljilja; Tomas, Ana; Gojkovic-Bukarica, Ljiljana; Ćebović, Tatjana; Milijašević, B.; Stilinović, Nebojša; Hogervorst, Jelena Cvejić

doi:10.1016/j.jsps.2019.08.006

Cited by 44 publications

(28 citation statements)

References 57 publications

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“…In the BPA + R30 group, it was observed that the plasma HDL and LDL levels were gradually restored to normal and the TG and TC concentrations also decreased. This may be attributed to the effects of RSV in stimulating energy metabolism and attenuating the hyperlipidemic symptoms induced by type 2 diabetes mellitus [ 58 ], which may have been retained in RBE after esterification, reducing the risk of cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota

Liao

Chen

Shih

et al. 2021

IJMS

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Resveratrol can affect the physiology or biochemistry of offspring in the maternal–fetal animal model. However, it exhibits low bioavailability in humans and animals. Fifteen-week SD pregnant female rats were orally administered bisphenol A (BPA) and/or resveratrol butyrate ester (RBE), and the male offspring rats (n = 4–8 per group) were evaluated. The results show that RBE treatment (BPA + R30) compared with the BPA group can reduce the damage caused by BPA (p < 0.05). RBE enhanced the expression of selected genes and induced extramedullary hematopoiesis and mononuclear cell infiltration. RBE increased the abundance of S24-7 and Adlercreutzia in the intestines of the male offspring rats, as well as the concentrations of short-chain fatty acids (SCFAs) in the feces. RBE also increased the antioxidant capacity of the liver by inducing Nrf2, promoting the expression of HO-1, SOD, and CAT. It also increased the concentration of intestinal SCFAs, enhancing the barrier formed by intestinal cells, thereby preventing BPA-induced metabolic disruption in the male offspring rats, and reduced liver inflammation. This study identified a potential mechanism underlying the protective effects of RBE against the liver damage caused by BPA exposure during the peri-pregnancy period, and the influence of the gut microbiota on the gut–liver axis in the offspring.

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Section: Discussionmentioning

confidence: 99%

Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota

Liao

Chen

Shih

et al. 2021

IJMS

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“…Other stilbenoids are rarely reported as antidiabetic agents. Resveratrol supplement improves metabolic control (Rašković et al., 2019), increases DNA integrity and sperm parameters (Bahmanzadeh, Goodarzi, Rezaei, Fathi, & Alizadeh, 2019), enhances insulin sensitivity (Sadi et al., 2015) and cardiovascular function (Yan, Sun, & Xu, 2018), prevents cognitive deficits by attenuating oxidative damage and inflammation (Gocmez et al., 2019), contributes hepatoprotective effects (Pektaş et al., 2016), alleviates testicular dysfunction (Faid, Al‐Hussaini, & Kilarkaje, 2015), reduces oxidative stress (Bagul, Deepthi, Sultana, & Banerjee, 2015) and inflammatory response (Sadi et al., 2015), and protects pancreatic β‐cell (Ku et al., 2012) in diabetic animals.…”

Section: Mechanisms Of Dietary Polyphenols As Antidiabetic Agentsmentioning

confidence: 99%

Dietary polyphenols as antidiabetic agents: Advances and opportunities

et al. 2020

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Dietary polyphenols have been widely investigated as antidiabetic agents in cell, animals, human study, and clinical trial. The number of publication (Indexed by Web of Science) on "polyphenols and diabetes" significantly increased since 2010. This review highlights the advances and opportunities of dietary polyphenols as antidiabetic agents.Dietary polyphenols prevent and manage Type 2 diabetes mellitus via the insulindependent approaches, for instance, protection of pancreatic islet -cell, reduction of -cell apoptosis, promotion of -cell proliferation, attenuation of oxidative stress, activation of insulin signaling, and stimulation of pancreas to secrete insulin, as well as the This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. c ○ 2020 The Authors. Food Frontiers published

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“…The addition of resveratrol in high-fat diet-fed rats, after 8-weeks of treatment prevented lipid peroxidation, reduced TNF-α levels, and attenuated nitric oxide synthase expression, while increasing the activity of CAT, SOD, and GPx enzymes [ 23 , 147 ]. In another study using the same experimental model [ 148 ], resveratrol not only reduced cholesterol and lipid levels but also reduced mRNA expression of HMG-CoA (β-Hydroxy β-methylglutaryl-CoA) reductase [ 149 ]. In this study, resveratrol also increased the Apo A-l/Apo B ratio.…”

Section: Resveratrol and Liver Disease: Scientific Evidence In Animentioning

confidence: 99%

The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials

et al. 2021

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Many studies have shown that resveratrol has a lot of therapeutic effects on liver disorders. Its administration can significantly increase the survival rate after liver transplantation, reduce fat deposition and ischemia-induced necrosis and apoptosis in Wistar rats. Resveratrol can provide Liver protection against chemical, cholestatic, and alcohol-mediated damage. It can improve glucose metabolism and lipid profile, reduce liver fibrosis, and steatosis. Additionally, it is capable of altering the fatty acid composition of the liver cells. Resveratrol may be a potential treatment option for the management of non-alcoholic fatty liver disease (NAFLD) due to its anti-inflammatory, antioxidant, and calorie-restricting effects. There are also studies that have evaluated the effect of resveratrol on lipid and liver enzyme profiles among patients with metabolic syndrome (MetS) and related disorders. Based on the extent of liver disease worldwide and the need to find new treatment possibilities, this review critically examines current in vitro and in vivo preclinical studies and human clinical studies related to liver protection.

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Resveratrol supplementation improves metabolic control in rats with induced hyperlipidemia and type 2 diabetes

Cited by 44 publications

References 57 publications

Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota

Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota

Dietary polyphenols as antidiabetic agents: Advances and opportunities

The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials

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