Resveratrol suppresses liver cancer progression by downregulating AKR1C3: targeting HCC with HSA nanomaterial as a carrier to enhance therapeutic efficacy

Wang, Ying; Su, Longxiang; Hu, Zhansheng; Peng, Shuang; Li, Na; Fu, Haiyan; Wang, Baoquan; Wu, Huiping

doi:10.1007/s10495-024-01995-w

Apoptosis

2024

DOI: 10.1007/s10495-024-01995-w

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Resveratrol suppresses liver cancer progression by downregulating AKR1C3: targeting HCC with HSA nanomaterial as a carrier to enhance therapeutic efficacy

Ying Wang,

Longxiang Su,

Zhansheng Hu

et al.

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Cited by 2 publications

References 90 publications

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Nano-encapsulation of drugs to target hepatic stellate cells: Toward precision treatments of liver fibrosis

Yuan,

Li,

Chen

et al. 2024

Journal of Controlled Release

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Nano-encapsulation of drugs to target hepatic stellate cells: Toward precision treatments of liver fibrosis

Yuan,

Li,

Chen

et al. 2024

Journal of Controlled Release

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The Role of Resveratrol in Cancer Management: From Monotherapy to Combination Regimens

Ribeiro,

Vale

2024

Targets

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Resveratrol, a naturally occurring polyphenol found in grapes, berries, and peanuts, has garnered significant attention for its potential anti-cancer properties. This review provides a comprehensive analysis of its role in cancer therapy, both as a standalone treatment and in combination with other therapeutic approaches. This review explores the molecular mechanisms underlying resveratrol’s anti-cancer effects, including its antioxidant activity, modulation of cellular signaling pathways, antiproliferative properties, anti-inflammatory effects, and epigenetic influences. This review also examines in vitro and in vivo studies that highlight resveratrol’s efficacy against various cancer types. Furthermore, the synergistic effects of resveratrol when used in conjunction with conventional treatments like chemotherapy and radiotherapy, as well as targeted therapies and immunotherapies, are discussed. Despite promising preclinical results, this review addresses the challenges and limitations faced in translating these findings into clinical practice, including issues of bioavailability and toxicity. Finally, it outlines future research directions and the potential for resveratrol to enhance existing cancer treatment regimens. This review aims to provide a thorough understanding of resveratrol’s therapeutic potential and to identify areas for further investigation in the quest for effective cancer treatments.

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Resveratrol suppresses liver cancer progression by downregulating AKR1C3: targeting HCC with HSA nanomaterial as a carrier to enhance therapeutic efficacy

Cited by 2 publications

References 90 publications

Nano-encapsulation of drugs to target hepatic stellate cells: Toward precision treatments of liver fibrosis

Nano-encapsulation of drugs to target hepatic stellate cells: Toward precision treatments of liver fibrosis

The Role of Resveratrol in Cancer Management: From Monotherapy to Combination Regimens

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