The increasing incidence of severe adenovirus cases underscores the
imperative for efficacious anti-adenovirus medications, given the
current absence of targeted therapeutic options. This study explores the
potential antiviral effects of the natural product Resveratrol (RSV) on
various cell lines, marking the first-time discovery of such properties.
The results suggest that RSV suppresses the upregulated pathways (NF-κB,
JAK-STAT) triggered by viral infections, with its mechanism contingent
upon the presence of the SIRT1 protein. Consequently, RSV mitigates the
expression of inflammatory factors (IL-6, IL-8) as detected by ELISA.
Subsequently, we elucidate the specific amino acid sites on both RSV and
SIRT1 using macromolecular docking and protein docking methodologies.
This revelation represents the pioneering elucidation of the mechanism
and mode of action of resveratrol as an antiviral agent. These promising
results establish the substantial potential of RSV as a therapeutic
agent against adenovirus-7. The capacity to proficiently hinder
adenovirus-7 replication and demonstrate potent antiviral properties in
vitro experiments introduces novel avenues for crafting targeted
therapies to combat adenovirus infections.