Resveratrol suppresses the invasion and migration of human gastric cancer cells via inhibition of MALAT1‑mediated epithelial‑to‑mesenchymal transition

Yang, Zhuying; Xie, Qiang; Chen, Zhanlei; Ni, Haibin; Xia, Liang; Zhao, Qiufeng; Chen, Zhiyun; Chen, Peifeng

doi:10.3892/etm.2018.7142

Cited by 29 publications

(25 citation statements)

References 51 publications

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“…Furthermore, resveratrol seems to regulate the expression of many genes involved in cell cycle control, cell–cell adhesion, and cellular movement, thus possibly also showing effects on cell mechanical properties [58]. This is further supported by studies in other cell lines showing changes in migration-related signaling pathways, thus inhibiting cellular migration and the endothelial-to-mesenchymal transition [59,60,61].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol-Induced Temporal Variation in the Mechanical Properties of MCF-7 Breast Cancer Cells Investigated by Atomic Force Microscopy

Iturri

Weber

Moreno-Cencerrado

et al. 2019

IJMS

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Atomic force microscopy (AFM) combined with fluorescence microscopy has been used to quantify cytomechanical modifications induced by resveratrol (at a fixed concentration of 50 µM) in a breast cancer cell line (MCF-7) upon temporal variation. Cell indentation methodology has been utilized to determine simultaneous variations of Young’s modulus, the maximum adhesion force, and tether formation, thereby determining cell motility and adhesiveness. Effects of treatment were measured at several time-points (0–6 h, 24 h, and 48 h); longer exposures resulted in cell death. Our results demonstrated that AFM can be efficiently used as a diagnostic tool to monitor irreversible morpho/nano-mechanical changes in cancer cells during the early steps of drug treatment.

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Section: Discussionmentioning

confidence: 99%

Resveratrol-Induced Temporal Variation in the Mechanical Properties of MCF-7 Breast Cancer Cells Investigated by Atomic Force Microscopy

Iturri

Weber

Moreno-Cencerrado

et al. 2019

IJMS

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“…It has been reported that resveratrol could modulate multiple pathways and the expression of lncRNAs, resulting in the suppression of proliferation, migration, and invasion of cancer cells [ 25 ]. For example, Geng et al suggested that resveratrol-mediated inhibition of NEAT1 repressed proliferation and migration of multiple myeloma cells via the Wnt/β-catenin signaling pathway [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Suppresses Human Nasopharyngeal Carcinoma Cell Growth Via Inhibiting Differentiation Antagonizing Non-Protein Coding RNA (DANCR) Expression

Zhang¹,

Jin²,

Zhou³

et al. 2020

Med Sci Monit

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Background Although resveratrol has been found to show anti-cancer effects and potential chemotherapeutic activities in several cancers, the role and molecular mechanisms of resveratrol in nasopharyngeal carcinoma (NPC) remains poorly understood. This study aimed to investigate the effect of resveratrol in NPC progression and its molecular mechanism. Material/Methods Quantitative real-time polymerase chain reaction and western blotting were used to detect the expression of DANCR and PTEN. MTT assay and EdU assay were performed to detect the cell proliferation in NPC cells with different treatment. The effect of resveratrol on cell migration was explored by Transwell migration assay. RNA immunoprecipitation assay and chromatin immunoprecipitation assay were performed to test the interaction between DANCR, EZH2, and PTEN. A mouse xenograft model of NPC cell was established, and immunohistochemistry assay was performed to detect the PTEN expression. Results Resveratrol treatment inhibited NPC cell growth and migration in a dose-dependent manner. Additionally, resveratrol downregulated the expression of DANCR and DANCR overexpressing abrogated the inhibition effect of resveratrol on NPC cell migration. Mechanistically, DANCR could bind to EZH2 and downregulated PTEN expression through mediating the binding of EZH2 on PTEN promoter. Furthermore, rescue experiments suggested resveratrol inhibited NPC cell growth and migration by the DANCR/PTEN pathway. Resveratrol significantly decreased the tumor volume and tumor weight and increased the expression of PTEN. Conclusions Resveratrol increased PTEN expression and suppressed NPC cell growth and migration through downregulation of DANCR.

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“…In gastric cancer SGC-7901 cells resveratrol inhibited EMT by suppressing the HH pathway [132]. Yang et al reported that resveratrol inhibited metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) mediated EMT, invasion, and migration, providing new indication for understanding the anticancer mechanism of resveratrol in BGC823 gastric cancer cells [213]. In oral squamous cell carcinoma CAL27 cells, resveratrol inhibited EMT, invasion and migration by suppressing EMT-inducing transcription factors and induced mitochondrial pathway mediated apoptosis [214].…”

Section: Therapeutic Implication Targeting Emtmentioning

confidence: 99%

The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges

Loh

Chai

Tang

et al. 2019

Cells

885

647

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Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due to its emerging role as a pivotal driver of tumorigenesis, targeting EMT is of great therapeutic interest in counteracting metastasis and chemoresistance in cancer patients. The hallmark of EMT is the upregulation of N-cadherin followed by the downregulation of E-cadherin, and this process is regulated by a complex network of signaling pathways and transcription factors. In this review, we summarized the recent understanding of the roles of E- and N-cadherins in cancer invasion and metastasis as well as the crosstalk with other signaling pathways involved in EMT. We also highlighted a few natural compounds with potential anti-EMT property and outlined the future directions in the development of novel intervention in human cancer treatments. We have reviewed 287 published papers related to this topic and identified some of the challenges faced in translating the discovery work from bench to bedside.

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Resveratrol suppresses the invasion and migration of human gastric cancer cells via inhibition of MALAT1‑mediated epithelial‑to‑mesenchymal transition

Cited by 29 publications

References 51 publications

Resveratrol-Induced Temporal Variation in the Mechanical Properties of MCF-7 Breast Cancer Cells Investigated by Atomic Force Microscopy

Resveratrol-Induced Temporal Variation in the Mechanical Properties of MCF-7 Breast Cancer Cells Investigated by Atomic Force Microscopy

Resveratrol Suppresses Human Nasopharyngeal Carcinoma Cell Growth Via Inhibiting Differentiation Antagonizing Non-Protein Coding RNA (DANCR) Expression

The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges

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